What is HMG (Human Menopausal Gonadotropin)?

Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.

HMG (Human Menopausal Gonadotropin) in the library · · Human Trials · What are peptides?

123 registered trials · 551 indexed papers · 1655 human / 99 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

HMG stands for human menopausal gonadotropin, also called menotropins. It supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity; the search term “HMG peptide” refers to this glycoprotein preparation.

Prescription menotropins have a clinical role in fertility treatment. A research vial with the same ingredient name is described as not necessarily matching the approved medicine’s contents, quality or instructions.

Overview (as described)

  • Menopur, a prescription hMG product, is purified from the urine of postmenopausal women. Its US indication is follicle development and pregnancy in ovulatory women undergoing assisted reproductive technology.
  • HMG, hCG and FSH are described as related but not interchangeable names that frequently appear together in fertility discussions.

Registered human trials (123)

TrialPhaseStatusYearEnrolled
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)Phase 3recruiting2026266
Evaluation of Treatments for Sore Throat Associated With Acute Pharyngitis and/or Viral Tonsillitisrecruiting2026160
Embryo QUAlity in Ovarian Stimulation With hMG.Phase 4not yet recruiting2026240
Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletesenrolling by invitation202660
HMG Treatment Reduces Sperm DNA FragmentationPhase 1completed2025114
Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.Phase 3recruiting2025659
Effects of Statins and Hormone Replacement Therapy in Coagulation Profile of Menopausal Women With Dyslipidemiarecruiting202570
Menopur And Rekovelle Combination Study Version 2.0Phase 2recruiting2025200
Oral Statins and Protection From Hearing LossPhase 4terminated20233
Mild Stimulation Protocol Using Clomiphene Citrate for Women With PCOS Undergoing in Vitro FertilizationPhase 4unknown2023154
Retrospective Analysis of Real-world Data From Medical Records on the Use of MENOPUR for Infertility Treatmentwithdrawn2022
Cumulative Pregnancy Rate With Lower and Higher Gonadotropin Dose During IVF Among Poor Responderscompleted2021190
Retrospective Cohort Observational Study to Evaluate the Effectiveness and Safety of Fresh or Frozen Embryo Transfercompleted20211166
Different Protocols in Ovarian Stimulation in Intracytoplasmic Sperm Injection Cycleswithdrawn2021
A Study Comparing MENOPUR in a Pen Formulation With a Powder and Solvent Formulation in Healthy WomenPhase 1completed202195
Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cyclesunknown2021200
Efficacy of Statin Addition to Neoadjuvant Chemotherapy Protocols for Breast CancerPhase 2/Phase 3unknown202160
Statins In Intracerbral HemorrhagePhase 3recruiting20201456
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSIPhase 4completed202050
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSIPhase 4completed202050
Pharmacogenomics in Prediction of Cardiovascular Drugs Adverse Reactionunknown20201200
An Observational Study of Follitropin Alpha Biosimilar: the Real-world Datacompleted20205484
Controlled Ovarian Hyperstimulation (COH) With Sequential HPFSH & HMG Versus Rec-F.S.H Alone in ICSI Cycleunknown2020100
Novel Therapy for Poor Responders Managementunknown2020100
FSH Followed by HMG vs FSH Plus HMG in IVFPhase 4unknown2020530
Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART)Phase 3completed2019405
Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.Phase 4completed201950
Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.Phase 4completed201950
Anti-Müllerian Hormone (AMH) Measured With Fully Automated Assay Versus AFC in the Prediction of Ovarian Responsecompleted2019160
Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate ResistancePhase 2/Phase 3completed2019161
The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian HyperstimulationPhase 4unknown20191892
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female InfertilityPhase 1/Phase 2completed2018200
Corifollitropin Alpha and Ovarian Responsecompleted2018300
Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)Phase 4unknown2018210
Menopur And Rekovelle Combination Studycompleted2018160
The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF CyclesPhase 4completed2017600
DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScorecompleted2017136
Corifollitropin Alfa Combined With Menotropin Versus Follitropin and Lutropin Alfa in Expected Suboptimal RespondersPhase 4completed201732
Study to Compare hFSH-HP (Fostipur) and hMG-HP(Meriofert) in Patients With Polycystic Ovary Under a IVF/ICSI Cycle.Phase 4terminated201719
Effects of SNP of GnRH Receptor Genes in IVF Patientsunknown20171500

Peer-reviewed studies (551)

PaperAuthorsJournalYearType
Blastocyst Morphology in Oocyte Donors stimulated During the Late Follicular Phase with either rFSH:rLH or HP-hMG in a PPOS protocol: a Pilot Randomized Controlled TrialCastillo-Velásquez F et al.JBRA assisted reproduction2026Randomized Controlled Trial
Human menopausal gonadotrophin in a pre-filled injection pen is non-inferior to the US-approved powder formulationWitz C et al.Reproductive biomedicine online2026Randomized Controlled Trial
Clinical efficacy and safety of two highly purified human menopausal gonadotropins in women undergoing in vitro fertilizationRao KA et al.Reproduction & fertility2025Randomized Controlled Trial
Human menopausal gonadotropin (HMG) combined different doses of letrozole for treating anovulatory infertility in patients with polycystic ovary syndrome: a randomized controlled trialLi J et al.Journal of assisted reproduction and genetics2025Randomized Controlled Trial
Comparison of outcomes between pulsatile gonadotropin releasing hormone and combined gonadotropin therapy of spermatogenesis in patients with congenital hypogonadotropic hypogonadismZheng Y et al.Reproductive biology and endocrinology : RB&E2025Clinical Trial
The ovarian stimulation regimen does not affect aneuploidy or blastocyst rateCozzolino M et al.Reproductive biomedicine online2024Observational Study
Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathwayYuan W et al.Diagnostic pathology2023Randomized Controlled Trial
Comparison of Three Ovulation Induction Therapies for Patients With Polycystic Ovary Syndrome and InfertilityXia TT et al.Journal of clinical pharmacology2023Randomized Controlled Trial
Ovulation induction using sequential letrozole/gonadotrophin in infertile women with PCOS: a randomized controlled trialDai X et al.Reproductive biomedicine online2023Randomized Controlled Trial
The LH endocrine profile in gonadotropin-releasing hormone analogue cyclesJanssens L et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2022Observational Study
Comparative analysis of IVF-ICSI outcomes between advanced and early stage of endometriosis stimulated with HMGArshad AH et al.The Medical journal of Malaysia2022Observational Study
IVF protocol efficacy in women with expected suboptimal response depending on ovary stimulation modeOb'edkova KV et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2021Randomized Controlled Trial
First pre-filled pen device with highly purified human menopausal gonadotropin (HP-hMG, Menopur) in liquid is shown to be bioequivalent to powder for reconstitutionJonker DM et al.International journal of clinical pharmacology and therapeutics2021Randomized Controlled Trial
Individualized ovarian stimulation for in vitro fertilization: a multicenter, open label, exploratory study with a mixed protocol of follitropin delta and highly purified human menopausal gonadotropinBissonnette F et al.Fertility and sterility2021Clinical Trial
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH AntagonistChapon RCB et al.JBRA assisted reproduction2021Randomized Controlled Trial
The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trialHosseini-Najarkolaei A et al.Reproductive biology and endocrinology : RB&E2020Randomized Controlled Trial
Randomized, assessor-blinded trial comparing highly purified human menotropin and recombinant follicle-stimulating hormone in high responders undergoing intracytoplasmic sperm injectionWitz CA et al.Fertility and sterility2020Clinical Study
Replacing HMG/FSH by low-dose HCG to complete corifollitropin alfa stimulation reduces cost per clinical pregnancy: a randomized pragmatic trialDecleer W et al.Reproductive biomedicine online2020Randomized Controlled Trial
Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled studyShi S et al.Medicine2020Randomized Controlled Trial
Contribution of recruitable follicles to circulating anti-Müllerian hormone levels following maximal gonadotrophin stimulation in patients with limited ovarian reserveGrynnerup AG et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2020Observational Study
Optimal treatment for spermatogenesis in male patients with hypogonadotropic hypogonadismLin J et al.Medicine2019Randomized Controlled Trial
A cohort study of both human menopausal gonadotropin (HMG) and recombinant luteinizing hormone addition at early follicular stage in in vitro fertilization outcome: A STROBE-compliant studyXia X et al.Medicine2019Observational Study
Treatment of idiopathic oligozoospermia with combined human chorionic gonadotropin/human menopausal gonadotrophin: A randomised, double-blinded, placebo-controlled clinical studyZhao N et al.Andrologia2019Randomized Controlled Trial
The impact of HCG in IVF Treatment: Does it depend on age or on protocol?Theofanakis C et al.Journal of gynecology obstetrics and human reproduction2019Randomized Controlled Trial
Ovarian stimulation with corifollitropin alfa followed by hp-hMG compared to hp-hMG in patients at risk of poor ovarian response undergoing ICSI: A randomized controlled trialTaronger R et al.European journal of obstetrics, gynecology, and reproductive biology2018Clinical Study
Neonate female to male ratio after assisted reproduction following antagonist and agonist protocolsAl-Jaroudi D et al.Medicine2018Observational Study
Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trialWang Y et al.Trials2018Randomized Controlled Trial
New trial of progestin-primed ovarian stimulation using dydrogesterone versus a typical GnRH antagonist regimen in assisted reproductive technologyIwami N et al.Archives of gynecology and obstetrics2018Controlled Clinical Trial
Comparison of modified agonist, mild-stimulation and antagonist protocols for in vitro fertilization in patients with diminished ovarian reserveYu R et al.The Journal of international medical research2018Randomized Controlled Trial
The effect of low-dose ovarian stimulation with HMG plus progesterone on pregnancy outcome in women with history of recurrent pregnancy loss and secondary infertility: a retrospective cohort studyCoccia ME et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2018Observational Study

More cited research

Conditions researched

Related compounds

FAQ

What is HMG (Human Menopausal Gonadotropin)?

Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.

How many registered human trials study HMG (Human Menopausal Gonadotropin)?

The PeptideWhiz trial index lists 123 registered trials for HMG (Human Menopausal Gonadotropin), the most recent from 2026.

How much published research exists on HMG (Human Menopausal Gonadotropin)?

The PeptideWhiz paper index links 551 PubMed papers to HMG (Human Menopausal Gonadotropin); by study type, 1655 human and 99 animal studies.

Which conditions is HMG (Human Menopausal Gonadotropin) researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Concussion, traumatic brain injury & stroke recovery, Endometriosis, Fat loss, obesity & body recomposition, Female fertility, Heart repair: after heart attack, heart failure & enlarged heart, High cholesterol and statins, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Low testosterone (without or alongside TRT), Male fertility and sperm, PCOS, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research