What is Kisspeptin-10?

A hypothalamic signaling peptide that triggers GnRH, and through it LH and FSH.

Kisspeptin-10 in the library · · Human Trials · What are peptides?

23 registered trials · 54 indexed papers · 512 human / 1940 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A hypothalamic signaling peptide that triggers GnRH, and through it LH and FSH.

Registered human trials (23)

TrialPhaseStatusYearEnrolled
Kisspeptin to Quantify GnRH Neuronal Function in Health and DiseasePhase 1recruiting202640
Kisspeptin Administration Subcutaneously to Patients With Hypothalamic AmenorrheaPhase 2recruiting202520
Functional Proteins in Polycystic Ovary Syndromerecruiting2025100
Kisspeptin Administration Subcutaneously to Patients With IHHPhase 2recruiting202336
Recall by Genotype: Neuropeptide StimulationPhase 1terminated202316
Dampening the Reproductive Axis With Continuous KisspeptinPhase 1completed20238
Evaluation of Some Puberty-related Hormones Among Children and Adolescents With Chronic Kidney Diseasesunknown202350
Kisspeptin Administration Subcutaneously to Patients With Reproductive DisordersPhase 1completed202213
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic ClampPhase 1withdrawn2022
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance TestPhase 1completed202116
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic HypogonadismPhase 2completed201918
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal TolerancePhase 1withdrawn2019
Administration of Kisspeptin in Patients With HyperprolactinemiaPhase 2completed201736
Serum Kisspeptin Levels in Infertile Womencompleted201690
Reproductive Hormones During Sustained Administration of Kisspeptinrecruiting201476
Neuropeptides in Human ReproductionPhase 1completed201461
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in MenPhase 3completed201415
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.Phase 3completed201430
Kisspeptin in the Evaluation of Delayed PubertyPhase 1completed201324
KP-10 and Insulin Secretion in MenPhase 3completed201314
The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) TreatmentPhase 2completed2012175
Elucidating Kisspeptin Physiology by Blocking Kisspeptin SignalingPhase 1completed201196
Kisspeptin Administration in the AdultPhase 1completed2009256

Peer-reviewed studies (54)

PaperAuthorsJournalYearType
Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy menYeung AC et al.European journal of endocrinology2026Randomized Controlled Trial
Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humansGalbiati F et al.Journal of neuroendocrinology2026Clinical Trial, Phase I
Serum Kisspeptin levels in patients undergoing maintenance hemodialysis: a case-control study protocolYang B et al.BMC nephrology2025Observational Study
Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humansMills EG et al.EBioMedicine2025Randomized Controlled Trial
Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in HumansMills EG et al.The Journal of clinical endocrinology and metabolism2025Randomized Controlled Trial
Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humansGalbiati F et al.European journal of endocrinology2025Clinical Trial, Phase I
Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot studyRodanaki M et al.Journal of pediatric endocrinology & metabolism : JPEM2025Randomized Controlled Trial
POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neuronsTalbi R et al.bioRxiv : the preprint server for biology2025Preprint
Kisspeptin expression levels in patients with placenta previa: A randomized trialKatirci Y et al.Medicine2024Randomized Controlled Trial
Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricalsAbbara A et al.Fertility and sterility2024Randomized Controlled Trial
Oral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteersBavato F et al.Journal of psychopharmacology (Oxford, England)2023Randomized Controlled Trial
Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical TrialMills EG et al.JAMA network open2023Randomized Controlled Trial
Serum kisspeptin levels in deep-infiltrating, ovarian, and superficial endometriosis: A prospective observational studyÖnal M et al.Medicine2022Observational Study
Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical TrialThurston L et al.JAMA network open2022Randomized Controlled Trial
Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy MenComninos AN et al.The Journal of clinical endocrinology and metabolism2022Randomized Controlled Trial
Evaluation of Kisspeptin levels in prepubertal obese and overweight children: sexual dimorphism and modulation of antioxidant levelsMancini A et al.European review for medical and pharmacological sciences2021Observational Study
The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy MenYang L et al.The Journal of clinical endocrinology and metabolism2021Randomized Controlled Trial
Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjectsChatree S et al.Experimental biology and medicine (Maywood, N.J.)2021Randomized Controlled Trial
Kisspeptin receptor agonist has therapeutic potential for female reproductive disordersAbbara A et al.The Journal of clinical investigation2020Clinical Trial
Female infertility is associated with an altered expression of the neurokinin B/neurokinin B receptor and kisspeptin/kisspeptin receptor systems in ovarian granulosa and cumulus cellsBlasco V et al.Fertility and sterility2020Clinical Trial
Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndromeSkorupskaite K et al.Human reproduction (Oxford, England)2020Randomized Controlled Trial
Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal DelayChan YM et al.The Journal of clinical endocrinology and metabolism2020Clinical Trial, Phase I
Kisspeptin enhances brain responses to olfactory and visual cues of attraction in menYang L et al.JCI insight2020Randomized Controlled Trial
Serum and follicular fluid levels of serotonin, kisspeptin, and brain-derived neurotrophic factor in patients undergoing in vitro fertilization: an observational study : Neurohormones in patients receiving IVFBódis J et al.The Journal of international medical research2020Observational Study
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndromeRomero-Ruiz A et al.Human reproduction (Oxford, England)2019Clinical Trial
A role for placental kisspeptin in β cell adaptation to pregnancyBowe JE et al.JCI insight2019Observational Study
Predictive value of serum kisspeptin concentration at 14 and 21 days after frozen-thawed embryo transferHu KL et al.Reproductive biomedicine online2019Clinical Trial
Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan WomenBranavan U et al.BioMed research international2019Clinical Trial
Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy menUllah H et al.Andrologia2019Clinical Trial, Phase III
Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functionsComninos AN et al.JCI insight2018Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Kisspeptin-10?

A hypothalamic signaling peptide that triggers GnRH, and through it LH and FSH.

How many registered human trials study Kisspeptin-10?

The PeptideWhiz trial index lists 23 registered trials for Kisspeptin-10, the most recent from 2026.

How much published research exists on Kisspeptin-10?

The PeptideWhiz paper index links 54 PubMed papers to Kisspeptin-10; by study type, 512 human and 1940 animal studies.

Which conditions is Kisspeptin-10 researched for?

Female fertility, Low testosterone (without or alongside TRT), Sexual function & libido (women and men), Menopause & perimenopause, Muscle gain, sarcopenia & building muscle after 40, Male fertility and sperm, Anxiety and panic, Endometriosis, Fat loss, obesity & body recomposition, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), PCOS, Pregnancy and breastfeeding: safety notes.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).