What is Enfuvirtide?

A 36-amino-acid peptide (Fuzeon) that blocks HIV from entering cells.

Enfuvirtide in the library · · Human Trials · What are peptides?

37 registered trials · 88 indexed papers · 101 human / 0 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 36-amino-acid peptide (Fuzeon) that blocks HIV from entering cells.

Type: Peptide drug.

Definition (National Library of Medicine)

“A synthetic 36-amino acid peptide that corresponds to the heptad repeat sequence of hiv-1 gp41.”

  • MeSH: Enfuvirtide

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Enfuvirtide is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (37)

TrialPhaseStatusYearEnrolled
Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 IndividualsEARLY_Phase 1completed201311
Optimizing Treatment for Treatment-Experienced, HIV-Infected PeoplePhase 3completed2008517
INNOVE Study: A Study of 3 Months Induction With Fuzeon (Enfuvirtide) + Optimized Background (OB) Versus OB Alone in HIV-1 Infected Patients With Virological Failure.Phase 2completed200829
ESP Study: A Study to Assess the Effect of Adding Fuzeon (Enfuvirtide) to an Antiretroviral Regimen in Fuzeon-Naive Patients With Sustained HIV Viral Suppression.Phase 4withdrawn2007
A Study of Fuzeon (Enfuvirtide) With an Integrase Inhibitor Plus Optimized Background in Treatment-Experienced HIV-1 Infected PatientsPhase 4terminated200729
Intensification With Enfuvirtide in Naive HIV-infected Patients (ANRS130)Phase 3completed2006195
BLQ Study: A Study of a Protease Inhibitor With Fuzeon (Enfuvirtide) in Treatment-Experienced Patients With HIV-1.Phase 4completed2006142
BOSS Study: A Study of Fuzeon Using the Needle-Free Biojector 2000 in Patients With HIV-1 InfectionPhase 4completed2006326
Fuzeon Viral Decay Pilot Studycompleted200618
Study of Valproic Acid to Treat HIV Infected AdultsPhase 1terminated200614
Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)Phase 2completed200530
A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of TherapyPhase 4completed20052
A Study of Enfuvirtide (Fuzeon) in Patients With Advanced Human Immunodeficiency Virus-1 (HIV-1) InfectionPhase 4completed20056
WAND Study - A Study to Evaluate Fuzeon (Enfuvirtide) Administered by a Needle-Free Injection Device in Patients With HIV.Phase 4completed200558
A Study to Evaluate the Safety and Efficacy of Adding Enfuvirtide to Oral Highly Active Antiretroviral Therapy (HAART) in Human Immunodeficiency Virus (HIV) Patients With Prior Treatment ExperiencePhase 4completed200547
A Study With TMC125 in Human Immunodeficiency Virus (HIV) Type 1 Infected Patients, Who Were Treated With TMC125 Arm in a Sponsor-Selected TMC125 StudyPhase 2completed2005211
Metabolic Effects of Enfuvirtide in Healthy VolunteersPhase 4completed200515
A 48 Week Study Comparing Treatment With Saquinavir + Lopinavir/Ritonavir in Combination With Enfuvirtide HAART Versus Saquinavir + Lopinavir/Ritonavir + Other Nucleoside Combinations to See the Efficacy of These Treatments in Patients Infected With HIV-1Phase 4terminated20048
A Study Comparing the Efficacy and Safety of Once-Daily Fuzeon (Enfuvirtide) Dosing Versus the Currently Recommended Twice-Daily Dosing in Human Immunodeficiency Virus-Type 1 (HIV-1) Infected PatientsPhase 2completed200464
QUALITE Study - A Study of Fuzeon (Enfuvirtide) in Treatment-Experienced Patients With Human Immunodeficiency Virus-1 (HIV-1) InfectionPhase 4completed2004361
A Study of Enfuvirtide (Fuzeon) in Participants With Advanced Human Immunodeficiency Virus (HIV) InfectionPhase 4completed200423
Efficacy, and Safety Study of Optimized Background Antiretroviral Regimen (OB) in Combination With Enfuvirtide in the Treatment-Experienced Participants With Human Immunodeficiency Virus-1 (HIV-1) InfectionPhase 3completed200484
Study of Enfuvirtide in HIV-Positive SubjectsPhase 1completed200426
Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adultscompleted200319
HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)Phase 4completed200380
Treatment Intensification for HIV Infected Patients With Multi-Drug Resistant Virusunknown200320
Cohort Study for Patients Using Fuzeon (Enfuvirtide)unknown2003200
Adding New Drugs for HIV Infected Patients Failing Current TherapyPhase 1/Phase 2completed200250
Fuzeon (Enfuvirtide) Early Access Program for Patients With HIV-1 InfectionPhase 3completed20025
Study of a New Anti-HIV Drug, T-20, in HIV-Infected ChildrenPhase 1completed200124
T-20 Plus a Selected Anti-HIV Treatment in HIV-Infected Children and AdolescentsPhase 2completed200152
HIV Maintenance Therapy With T-20 During HAART InterruptionPhase 2completed200110
A Study of T-20 in HIV-Positive AdultsPhase 2completed200178
T-20 With Anti-HIV Combination Therapy for Patients With Prior Anti-HIV Drug Treatment and/or Drug Resistance to Each of the Three Classes of Approved Anti-HIV DrugsPhase 3completed2001525
T-20 in HIV Patients With Prior Drug Treatment and/or Resistance to Each of the Three Classes of Anti-HIV DrugsPhase 3completed2001525
Pilot Study Evaluating Interruption of Enfuvirtide (Fuzeon, T20) in Patients With Enfuvirtide ResistancePhase 4completed200025
A Study to Compare Three Doses of T-20 When Given in Combination With Abacavir, Amprenavir, Ritonavir, and Efavirenz to HIV-Infected AdultsPhase 2completed199968

Peer-reviewed studies (88)

PaperAuthorsJournalYearType
Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: Randomized crossover clinical trial in healthy volunteersBarroso S et al.PloS one2019Randomized Controlled Trial
Incidence and risk factors for liver enzymes elevations in highly treatment-experienced patients switching from enfuvirtide to raltegravir: a sub-study of the ANRS-138 EASIER trialde Castro N et al.AIDS research and therapy2016Randomized Controlled Trial
Regimen selection in the OPTIONS trial of HIV salvage therapy: drug resistance, prior therapy, and race-ethnicity determine the degree of regimen complexityTashima KT et al.HIV clinical trials2015Clinical Trial
Pharmacokinetics of sifuvirtide in treatment-naive and treatment-experienced HIV-infected patientsMeng Q et al.Journal of pharmaceutical sciences2014Randomized Controlled Trial
Decreases in inflammatory and coagulation biomarkers levels in HIV-infected patients switching from enfuvirtide to raltegravir: ANRS 138 substudySilva EF et al.The Journal of infectious diseases2013Randomized Controlled Trial
Residual plasma viraemia and infectious HIV-1 recovery from resting memory CD4 cells in patients on antiretroviral therapy: results from ACTG A5173Gandhi RT et al.Antiviral therapy2013Clinical Trial
Intensification of antiretroviral therapy through addition of enfuvirtide in naive HIV-1-infected patients with severe immunosuppression does not improve immunological response: results of a randomized multicenter trial (ANRS 130 Apollo)Joly V et al.Antimicrobial agents and chemotherapy2013Randomized Controlled Trial
Role and evolution of viral tropism in patients with advanced HIV disease receiving intensified initial regimen in the ANRS 130 APOLLO trialCharpentier C et al.The Journal of antimicrobial chemotherapy2013Randomized Controlled Trial
Lack of benefit of 3-month intensification with enfuvirtide plus optimized background regimen (OBR) versus OBR alone in patients with multiple therapeutic failures: the INNOVE studyMorand-Joubert L et al.Journal of medical virology2012Randomized Controlled Trial
Vicriviroc resistance decay and relative replicative fitness in HIV-1 clinical isolates under sequential drug selection pressuresTsibris AM et al.Journal of virology2012Clinical Trial, Phase II
Short-term additional enfuvirtide therapy is associated with a greater immunological recovery in HIV very late presenters: a controlled pilot studyBonora S et al.Infection2012Clinical Trial
Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapyGasnault J et al.PloS one2011Clinical Trial
Efficacy and safety of raltegravir in treatment-experienced HIV-1-infected patients switching from enfuvirtide-based regimens: 48 week results of the randomized EASIER ANRS 138 trialGallien S et al.The Journal of antimicrobial chemotherapy2011Randomized Controlled Trial
Two-year safety and tolerability study of enfuvertide use in salvage therapy of Thai HIV-1 experienced casesPrasithsirikul W et al.Journal of the Medical Association of Thailand = Chotmaihet thangphaet2011Clinical Trial
The effects of enfuvirtide therapy on body composition and metabolic parameters over 48 weeks in the TORO body imaging substudyCooper DA et al.HIV medicine2011Randomized Controlled Trial
Impact on health-related quality of life of a switch from enfuvirtide to raltegravir among multidrug-resistant HIV-1-infected patients: a randomized open-label trial (EASIER-ANRS 138)Boulet T et al.HIV clinical trials2010Randomized Controlled Trial
A 48-week pilot study switching suppressed patients to darunavir/ritonavir and etravirine from enfuvirtide, protease inhibitor(s), and non-nucleoside reverse transcriptase inhibitor(s)Ruane P et al.AIDS research and human retroviruses2010Clinical Trial, Phase III
Efficacy and safety of etravirine at week 96 in treatment-experienced HIV type-1-infected patients in the DUET-1 and DUET-2 trialsKatlama C et al.Antiviral therapy2010Randomized Controlled Trial
Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapyYilmaz A et al.Journal of acquired immune deficiency syndromes (1999)2010Randomized Controlled Trial
Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infectionArchin NM et al.PloS one2010Clinical Trial
No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapyGandhi RT et al.The Journal of infectious diseases2010Clinical Trial
Sustained HIV RNA suppression after switching from enfuvirtide to etravirine in the early access programmeLoutfy M et al.The Journal of antimicrobial chemotherapy2009Clinical Trial
Enfuvirtide: a safe and effective antiretroviral agent for human immunodeficiency virus-infected patients shortly after liver transplantationTeicher E et al.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2009Clinical Trial
Switch from enfuvirtide to raltegravir in virologically suppressed multidrug-resistant HIV-1-infected patients: a randomized open-label trialDe Castro N et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America2009Randomized Controlled Trial
Virologic outcomes of changing enfuvirtide to raltegravir in HIV-1 patients well controlled on an enfuvirtide based regimen: 24-week results of the CHEER studyTowner W et al.Journal of acquired immune deficiency syndromes (1999)2009Clinical Trial
Immunological success is predicted by enfuvirtide but not interleukin-2 therapy in immunodepressed patientsViard JP et al.AIDS (London, England)2009Randomized Controlled Trial
Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adultsJacobson JM et al.Antimicrobial agents and chemotherapy2009Randomized Controlled Trial
Switching from a toxicity-causing antiretroviral to enfuvirtide in patients with HIV: the SWITCH TOX studyStreinu-Cercel A et al.HIV clinical trials2008Clinical Trial, Phase IV
Safety and efficacy of enfuvirtide in combination with darunavir-ritonavir and an optimized background regimen in treatment-experienced human immunodeficiency virus-infected patients: the below the level of quantification studyDeJesus E et al.Antimicrobial agents and chemotherapy2008Clinical Trial
A randomized, controlled study evaluating an induction treatment strategy in which enfuvirtide was added to an oral, highly active antiretroviral therapy regimen in treatment-experienced patients: the INTENSE studyClotet B et al.The Journal of antimicrobial chemotherapy2008Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Enfuvirtide?

A 36-amino-acid peptide (Fuzeon) that blocks HIV from entering cells.

How many registered human trials study Enfuvirtide?

The PeptideWhiz trial index lists 37 registered trials for Enfuvirtide, the most recent from 2013.

How much published research exists on Enfuvirtide?

The PeptideWhiz paper index links 88 PubMed papers to Enfuvirtide; by study type, 101 human and 0 animal studies.

Which conditions is Enfuvirtide researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Fat loss, obesity & body recomposition, Immune system (general), Kidney protection (CKD, diabetic kidney, lupus kidney).

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research