What is CGRP (Calcitonin Gene-Related Peptide)?
A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
CGRP (Calcitonin Gene-Related Peptide) in the library · · Human Trials · What are peptides?
6 registered trials · 621 indexed papers · 978 human / 1020 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Type: Neuropeptide.
Definition (National Library of Medicine)
“A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.”
- MeSH: Calcitonin Gene-Related Peptide
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when CGRP (Calcitonin Gene-Related Peptide) is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (6)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| The Hemodynamic Effects of CGRP After Glibenclamide Administration in Healthy Volunteers | completed | 2020 | 20 | |
| Clinical Characteristics and Pathophysiology of Post-Traumatic Headache | completed | 2018 | 200 | |
| The Effect of Sumatriptan and Placebo on CGRP Induced Headache | completed | 2018 | 30 | |
| Pharmacologically Triggered Migraine Without Aura and Neuroimaging | unknown | 2016 | 36 | |
| CGRP-induced Migraine Attacks in Patients Who Have Tried Anti-CGRP Monoclonal Antibody Treatment | unknown | 2016 | 40 | |
| Functional MRI (fMRI) in CGRP Induced Migraine | completed | 2006 | 12 |
Peer-reviewed studies (621)
More cited research
- Calcitonin gene-related peptide promotes mast cell-mediated neuroimmune inflammation through the CALCRL/RAMP1-JAK3-STAT1 axis in rosacea (2026, human observational)
- Comparative Analysis of CGRP, VIP and PACAP-38 Levels in Migraine with and Without Aura: A Case-control Study (2025, human observational)
- Development and pharmacological characterization of novel multi- calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide receptor ant (2025, human observational)
- Food-specific IgG-based elimination diet decreased IL-6, TNF-α, and CGRP and improved symptoms in adults with migraine (2025, human RCT)
- Therapeutic Effects of Phytoestrogen Naringenin in Polycystic Ovary Syndrome (PCOS): Involvement of Kisspeptin and Calcitonin Gene Related Peptide Signalling Pa (2025, animal)
- The vasoactive effects of bradykinin, vasoactive intestinal peptide, calcitonin gene-related peptide and neuropeptide Y depend on the perivascular tissue in por (2024, animal)
- Vascular actions of peripheral CGRP in migraine-like photophobia in mice (2020, animal)
- Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine (2019, animal)
Conditions researched
- Migraine
- Atherosclerosis, cardiovascular disease & high blood pressure
- Candida & persistent bacterial infections
- Chronic and systemic inflammation
- Chronic pain: fibromyalgia & CRPS
- Concussion, traumatic brain injury & stroke recovery
- EBV and reactivated viruses
- Endometriosis
- Fat loss, obesity & body recomposition
- Fatty liver & elevated liver enzymes
- Skin sensitivity and body aches on GLP-1 medicines
- Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers
- Heart repair: after heart attack, heart failure & enlarged heart
- Immune system (general)
- Insulin resistance, prediabetes & type 2 diabetes
- Kidney protection (CKD, diabetic kidney, lupus kidney)
- Lung health, asthma & COPD
- Menopause & perimenopause
- Menstrual cramps (dysmenorrhea)
- Neuropathy and CRPS
- Osteoarthritis, cartilage loss & avoiding joint replacement
- Pancreatitis (after the acute phase)
- Post-surgical inflammation and surgery recovery
- Psoriasis and psoriatic arthritis
- Raynaud's
- Recurring UTIs
- Rosacea
- Skin, hair loss, wounds & mast-cell/histamine reactivity
- Tendon, ligament, muscle & joint injuries (incl. athletes)
- Trigeminal neuralgia
Related compounds
- Calcitonin
- ACTH (Corticotropin)
- BPC-157
- Endothelin-1
- Glutathione
- Parathyroid Hormone (PTH 1-84)
- Substance P
- Oxytocin
- Vasopressin
- Cyanocobalamin (Vitamin B12)
FAQ
What is CGRP (Calcitonin Gene-Related Peptide)?
A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
How many registered human trials study CGRP (Calcitonin Gene-Related Peptide)?
The PeptideWhiz trial index lists 6 registered trials for CGRP (Calcitonin Gene-Related Peptide), the most recent from 2020.
How much published research exists on CGRP (Calcitonin Gene-Related Peptide)?
The PeptideWhiz paper index links 621 PubMed papers to CGRP (Calcitonin Gene-Related Peptide); by study type, 978 human and 1020 animal studies.
Which conditions is CGRP (Calcitonin Gene-Related Peptide) researched for?
Migraine, Atherosclerosis, cardiovascular disease & high blood pressure, Candida & persistent bacterial infections, Chronic and systemic inflammation, Chronic pain: fibromyalgia & CRPS, Concussion, traumatic brain injury & stroke recovery, EBV and reactivated viruses, Endometriosis, Fat loss, obesity & body recomposition, Fatty liver & elevated liver enzymes, Skin sensitivity and body aches on GLP-1 medicines, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Lung health, asthma & COPD, Menopause & perimenopause, Menstrual cramps (dysmenorrhea), Neuropathy and CRPS, Osteoarthritis, cartilage loss & avoiding joint replacement, Pancreatitis (after the acute phase), Post-surgical inflammation and surgery recovery, Psoriasis and psoriatic arthritis, Raynaud's, Recurring UTIs, Rosacea, Skin, hair loss, wounds & mast-cell/histamine reactivity, Tendon, ligament, muscle & joint injuries (incl. athletes), Trigeminal neuralgia.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).