What is Parathyroid Hormone (PTH 1-84)?

The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Parathyroid Hormone (PTH 1-84) in the library · · Human Trials · What are peptides?

39 registered trials · 2352 indexed papers · 2748 human / 206 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Type: Peptide hormone.

Definition (National Library of Medicine)

“A polypeptide hormone (84 amino acid residues) secreted by the parathyroid glands which performs the essential role of maintaining intracellular calcium levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of calcium from bone, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.”

  • MeSH: Parathyroid Hormone

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Parathyroid Hormone (PTH 1-84) is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (39)

TrialPhaseStatusYearEnrolled
Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdismunknown202460
Fibroblast Growth Factor 23 and Sclerostin in Relation to Calcium in COVID-19 Patientscompleted202266
A Clinical Study of rhPTH(1-84) Treatment in Japanese Participants With Chronic HypoparathyroidismPhase 3withdrawn2022
Evluation of Thyroid Functions in Hemodialysis Childern in Sohag University Hospitalunknown202239
A Study of Relative Bioavailability of a New Formulation Compared With the Approved Formulation of rhPTH [1-84] and to Find Out Dose Linearity of the New Formulation in Healthy AdultsPhase 1completed202196
The Association Between Parathyroid Hormone and Preterm Laborcompleted2021100
Parathyroid Hormone Kinetics During CRRTcompleted201930
Safety and Efficacy Study of rhPTH(1-84) in Subjects With HypoparathyroidismPhase 3terminated201822
Preoperational Fine Needle Aspiration of Pathological Parathyroid Glandwithdrawn2018
Oral PTH(1-34) PK and PD Study in Patients With HypoparathyroidismPhase 2completed201820
Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult SubjectsPhase 1completed201724
Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With HypoparathyroidismPhase 1completed201734
Vitamin D Status With Early Childhood Cariescompleted201760
A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in HypoparathyroidismPhase 4completed201639
Corticosteroid Rhythms in Hypoparathyroid PatientsEARLY_Phase 1unknown201630
Prevalence of Secondary Hyperparathyroidism Among Patients With Diabetic Nephropathycompleted2014437
Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomycompleted2012300
Treatment With PTH After Sternotomy in Cardiac Surgery PatientsPhase 3completed201220
Parathyroid Hormone for the Treatment of Humerus FracturesPhase 4unknown201272
ADD-ON Study to Existing Hypoparathyroidism StudiesPhase 3unknown201062
HEXT (Hypo EXTended): Effect of PTH on Skeleton in HypoparathyroidismPhase 3completed200962
Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic HypoparathyroidismPhase 2completed200821
PTH & Ibandronate Combination Study (PICS)Phase 2/Phase 3completed200844
The Effect of PTH(1-84) or Alendronate on Reduction of Back Pain in Postmenopausal Women With an Osteoporosis Related Vertebral Fracture(s) (FP-005-IM)Phase 4terminated200875
Adherence to PTH(1-84) Treatment (FP-002-IM)completed20071179
Effect of Full Length Parathyroid Hormone, PTH(1-84) or Strontium Ranelate on Bone Markers in Postmenopausal Women With Primary Osteoporosis (FP-006-IM)Phase 4completed200782
STEP: Study of Imaging Techniques (ImaTx and DXA) in Postmenopausal Women With OstEoporosis Using Preotact (FP-008-ES)Phase 4completed2007129
Cinacalcet to Treat Familial Primary HyperparathyroidismPhase 3completed200625
7 Day Continuous Parathyroid Hormone IV InfusionEARLY_Phase 1completed200611
Sequential Treatment of Postmenopausal Women With Primary Osteoporosis (FP-001-IM)Phase 3completed2006407
PROPOSE Quality - PReOtact in Postmenopausal OStEoporosis - Quality of Life Study (FP-004-DE)completed2006110
Risedronate and Parathyroid Hormone to Reverse Osteoporosis Caused by Chronic Steroid UsePhase 4completed200560
Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal WomenPhase 2completed200480
rhPTH Therapy for Low Turnover Bone FragilityPhase 1terminated20032
Treatment of Psoriasis With Parathyroid HormonePhase 1/Phase 2completed200040
Randomized Study of Human Parathyroid Hormone in Middle-Aged Men With Idiopathic Osteoporosiscompleted199936
Effects of Parathyroid Hormone in Men With OsteoporosisPhase 3completed199981
Can Parathyroid Hormone Injections Reverse Glucocorticoid-induced OsteoporosisPhase 2completed1999
Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34Phase 2completed199127

Peer-reviewed studies (2352)

PaperAuthorsJournalYearType
Vitamin D status and adiposity in children with low-energy fractures: a prospective case-control studyCosentino A et al.European journal of pediatrics2026Observational Study
Low Prevalence of Exploratory Biochemical Patterns Compatible with Osteomalacia in a Large Cohort of Participants with Low Serum 25-Hydroxyvitamin D LevelsJorde R et al.Calcified tissue international2026Randomized Controlled Trial
Near-infrared autofluorescence parathyroid imaging during total thyroidectomy to reduce the rate of postoperative hypoparathyroidism: A prospective two-center randomized clinical trial with a comprehensive long-term follow-upAndersen AO et al.Surgery2026Randomized Controlled Trial
Breast milk intake, intact parathyroid hormone, and %tubular phosphate reabsorption as predictors of bone mineral density at term-equivalent age in very preterm and/or low-birth-weight infants: A prospective cohort studyTakami N et al.Early human development2026Observational Study
Parathyroid autotransplantation into the brachioradialis protects parathyroid function during total thyroidectomyWang S et al.Frontiers in endocrinology2026Clinical Trial
Efficacy and safety of ferric citrate tablets in Chinese patients with hyperphosphatemia undergoing maintenance hemodialysis: a multicenter, randomized, open-label, active-controlled, phase III trialMa J et al.Renal failure2026Randomized Controlled Trial
Real-world data for effectiveness and safety of palopegteriparatide in patients with chronic hypoparathyroidism: the PaTH REAL studyYavropoulou MP et al.European journal of endocrinology2026Observational Study
Acute effects of Greek yogurt consumption on bone status indices following high-intensity interval exercise in premenopausal females with obesity: a secondary analysis from a randomized crossover trialGagnon S et al.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2026Randomized Controlled Trial
A 10-month cluster-randomized trial to shift towards plant-forward meals in early childhood education and care centres: effects on bone and mineral metabolism in Finnish childrenItkonen ST et al.European journal of nutrition2026Randomized Controlled Trial
Impact of Vitamin D Replacement on the Vitamin D-Leptin-Prolidase Axis in Secondary HyperparathyroidismAsik HK et al.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2026Observational Study
Improving postthyroidectomy care using a parathyroid hormone and calcium-based algorithmGheorghe-Milea A et al.European journal of endocrinology2026Observational Study
Breast milk-associated physiological hypercalcaemia: an observational study of clinical, biochemical and radiological outcomesGovindarajan S et al.BMJ paediatrics open2026Observational Study
Sustained improvement in renal function with palopegteriparatide in adults with chronic hypoparathyroidism: 2-year results from the phase 3 PaTHway-trialRejnmark L et al.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2026Randomized Controlled Trial
Continuous subcutaneous recombinant PTH(1-34) infusion improves serum calcium and phosphate homeostasis in children with autosomal dominant hypocalcemia type 1 refractory to standard-of-care treatmentVincent A et al.European journal of endocrinology2026Observational Study
The Dose-Response Effects of Vitamin D(3) on Serum 25-Hydroxyvitamin D Levels in Vitamin D-Deficient Young Indian Women: A Randomized Controlled TrialPeris CH et al.Nutrients2026Randomized Controlled Trial
[Prevention of hypoparathyroidism with indocyanine green in transoral thyroidectomy: Pilot study]Domínguez-Rangel JA et al.Revista medica del Instituto Mexicano del Seguro Social2026Observational Study
Higher 25(OH)D Levels at Admission Predict a Favorable Disease Evolution in Moderate-to-Severe COVID-19 PatientsRizzi M et al.International journal of molecular sciences2026Observational Study
Risk of bone overstimulation in long-term PTH(1-34) therapy for hypoparathyroidismFischler R et al.European journal of endocrinology2026Observational Study
Effect of dialysate buffer practices on serum parathyroid hormone concentrations in real-life french patients receiving hemodialysisUreña Torres PA et al.PloS one2026Observational Study
Muscle Function Improves After Parathyroidectomy: The Role of Calcium Reduction Over Parathyroid Hormone DeclineErtürk B et al.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association2026Observational Study
Impact of High Doses of Vitamin D on Specific Metabolic Parameters in Type 2 Diabetes Patients: A Prospective Biomedical StudyMax F et al.International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition2026Observational Study
Discovery and characterization of canvuparatide, a once-weekly parathyroid hormone analog for the treatment of hypoparathyroidismZhang F et al.Molecular metabolism2026Randomized Controlled Trial
Biochemical osteomalacia during pregnancy or lactation: an observational study in SwedenTorstensson T et al.BMC pregnancy and childbirth2026Observational Study
Subtype- and treatment-based analysis of calcium dynamics in primary aldosteronismNakamura T et al.European journal of endocrinology2026Observational Study
Routine vs Selective Calcium Supplementation After Total Thyroidectomy: A Randomized Clinical TrialGarcia-Lozano C et al.JAMA otolaryngology-- head & neck surgery2026Randomized Controlled Trial
Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecturede Almeida CM et al.Obesity (Silver Spring, Md.)2026Clinical Trial
Correlation of carotid artery intima-media thickness with parameters of mineral bone disorder in patients with chronic kidney diseaseArora A et al.The National medical journal of India2026Observational Study
Palopegteriparatide for adults with chronic hypoparathyroidism: skeletal dynamics through 3 years of the phase 2 PaTH forward trialRubin MR et al.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2026Randomized Controlled Trial
Association of Anatomical Location with Outcomes after Microwave Ablation Treatment of Parathyroid AdenomasUrfalı FE et al.Journal of vascular and interventional radiology : JVIR2026Observational Study
Importance of oxyphil cells for parathyroid hormone/calcium concentrations in primary hyperparathyroidism: a retrospective observational studyDropmann JA et al.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026Observational Study

More cited research

Conditions researched

Related compounds

FAQ

What is Parathyroid Hormone (PTH 1-84)?

The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

How many registered human trials study Parathyroid Hormone (PTH 1-84)?

The PeptideWhiz trial index lists 39 registered trials for Parathyroid Hormone (PTH 1-84), the most recent from 2024.

How much published research exists on Parathyroid Hormone (PTH 1-84)?

The PeptideWhiz paper index links 2352 PubMed papers to Parathyroid Hormone (PTH 1-84); by study type, 2748 human and 206 animal studies.

Which conditions is Parathyroid Hormone (PTH 1-84) researched for?

Anemia, Ankylosing spondylitis, Anti-aging & longevity, Atherosclerosis, cardiovascular disease & high blood pressure, Celiac disease and gluten sensitivity, Chronic and systemic inflammation, Concussion, traumatic brain injury & stroke recovery, EBV and reactivated viruses, Endometriosis, Fat loss, obesity & body recomposition, Gum disease (periodontal) & oral health, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, High cholesterol and statins, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), Hyperparathyroidism, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Low testosterone (without or alongside TRT), Lung health, asthma & COPD, Menopause & perimenopause, Menstrual cramps (dysmenorrhea), Migraine, Multiple sclerosis, Muscle gain, sarcopenia & building muscle after 40, Neuropathy and CRPS, Osteoarthritis, cartilage loss & avoiding joint replacement, Osteoporosis and bone density, Pancreatitis (after the acute phase), Parkinson's disease, PCOS, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Psoriasis and psoriatic arthritis, Recurring UTIs, Rheumatoid arthritis, Seasonal allergies, Sexual function & libido (women and men), Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep apnea (obstructive), Sleep problems (incl. insomnia on peptides), Thyroid problems.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).