What is FOXO4-DRI?
A D-retro-inverso peptide described as disrupting FOXO4–p53 binding to clear senescent cells in research.
FOXO4-DRI in the library · · Human Trials · What are peptides?
0 registered trials · 0 indexed papers · 2 human / 6 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
FOXO4-DRI is described as a senolytic peptide whose stated research goal is selectively clearing senescent cells by disrupting FOXO4–p53 binding.
Overview (as described)
- It is described as a research-use-only compound.
More cited research
- Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence (2026, human observational)
- Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis (2021, human observational)
- FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway (2025, animal)
- FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells (2024, animal)
- FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice (2023, animal)
- FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice (2020, animal)
Related compounds
- Adipotide
- B7-33
- Colivelin
- Dihexa
- Epitalon
- FGL Peptide
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- GHK-Cu (Copper peptide)
- HGH Fragment 176-191
- Humanin
FAQ
What is FOXO4-DRI?
A D-retro-inverso peptide described as disrupting FOXO4–p53 binding to clear senescent cells in research.
How many registered human trials study FOXO4-DRI?
The PeptideWhiz trial index lists 0 registered trials for FOXO4-DRI.
How much published research exists on FOXO4-DRI?
By study type, PeptideWhiz counts 2 human and 6 animal studies on FOXO4-DRI.
Which conditions is FOXO4-DRI researched for?
No condition pages are linked to this compound yet.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).