What is Petrelintide?
A long-acting human amylin analog from Zealand Pharma, in phase 2 obesity trials.
Petrelintide in the library · Metabolic & Weight Peptides · Human Trials · What are peptides?
9 registered trials · 2 indexed papers · 1 human / 0 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
Mechanism (as described)
- It activates amylin receptors to promote fullness.
Evidence (as described)
- Phase 1 trials reported tolerability and weight loss (Brændholt Olsen et al., 2026); the phase 2 ZUPREME 1 trial was published in 2026 (Garvey et al., Lancet Diabetes Endocrinol 2026).
Status
Investigational.
Registered human trials (9)
Peer-reviewed studies (2)
| Paper | Authors | Journal | Year | Type |
|---|---|---|---|---|
| Petrelintide, a human amylin analogue for the treatment of obesity (ZUPREME 1): a randomised, double-blind, placebo-controlled, phase 2 trial | Garvey WT et al. | The lancet. Diabetes & endocrinology | 2026 | Randomized Controlled Trial |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Petrelintide for Weight Management: Two Randomized, Controlled Phase 1 Trials | Brændholt Olsen M et al. | Diabetes, obesity & metabolism | 2026 | Randomized Controlled Trial |
Conditions researched
- Atherosclerosis, cardiovascular disease & high blood pressure
- Fat loss, obesity & body recomposition
- Insulin resistance, prediabetes & type 2 diabetes
- Kidney protection (CKD, diabetic kidney, lupus kidney)
Related compounds
- CagriSema (Cagrilintide + Semaglutide)
- Dulaglutide
- Exenatide
- Liraglutide
- Orforglipron (Foundayo, non-peptide)
- ACTH (Corticotropin)
- ANP (Atrial Natriuretic Peptide)
- Adrenomedullin
- Alpha-MSH
- Angiotensin II
FAQ
What is Petrelintide?
A long-acting human amylin analog from Zealand Pharma, in phase 2 obesity trials.
How many registered human trials study Petrelintide?
The PeptideWhiz trial index lists 9 registered trials for Petrelintide, the most recent from 2026.
How much published research exists on Petrelintide?
The PeptideWhiz paper index links 2 PubMed papers to Petrelintide; by study type, 1 human and 0 animal studies.
Which conditions is Petrelintide researched for?
Atherosclerosis, cardiovascular disease & high blood pressure, Fat loss, obesity & body recomposition, Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney).
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).