What is Adrenomedullin?
A 52-amino-acid peptide that widens blood vessels; studied as an infusion in heart, lung and gut conditions.
Adrenomedullin in the library · · Human Trials · What are peptides?
7 registered trials · 243 indexed papers · 265 human / 30 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A 52-amino-acid peptide that widens blood vessels; studied as an infusion in heart, lung and gut conditions.
Type: Peptide hormone.
Definition (National Library of Medicine)
“A 52-amino acid peptide with multi-functions. It was originally isolated from pheochromocytoma and adrenal medulla but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.”
- MeSH: Adrenomedullin
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Adrenomedullin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (7)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Selective Activation of the Adrenomedullin Receptors in Migraine | recruiting | 2026 | 26 | |
| Hypersensitivity to Adrenomedullin in Post-Traumatic Headache | recruiting | 2025 | 21 | |
| Adrenomedullin for CADASIL | Phase 2 | completed | 2022 | 60 |
| Role of Adrenomedullin in Leukemic Endosteal/Vascular Niches | active not recruiting | 2021 | 72 | |
| Assessment of the Safety, Tolerability, and Pharmacokinetic of HM201 | Phase 1 | completed | 2021 | 53 |
| Adrenomedullin Effect on Migraine Without Patients | completed | 2019 | 20 | |
| The Role of Adrenomedullin on the Outcome of Severe Heart Failure: a Clinical Randomized Study | withdrawn | 2010 |
Peer-reviewed studies (243)
More cited research
- Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle (1999, human observational)
- Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (None, human trial (non-randomized))
- Investigation of the effect of different regulatory peptides on adrenocortical cell proliferation in immature rats: evidence that endogenous adrenomedullin exer (2002, animal)
- Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat (1999, animal)
- Adrenomedullin synergistically interacts with endogenous vasodilators in rats: a possible role of K(ATP) channels (1998, animal)
- Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells (1995, animal)
Conditions researched
- Anxiety and panic
- Atherosclerosis, cardiovascular disease & high blood pressure
- Candida & persistent bacterial infections
- Chronic and systemic inflammation
- Concussion, traumatic brain injury & stroke recovery
- Fat loss, obesity & body recomposition
- Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers
- Heart repair: after heart attack, heart failure & enlarged heart
- Immune system (general)
- Insulin resistance, prediabetes & type 2 diabetes
- Kidney protection (CKD, diabetic kidney, lupus kidney)
- Lung health, asthma & COPD
- Migraine
- PCOS
- Post-surgical inflammation and surgery recovery
- POTS and dysautonomia
- Pregnancy and breastfeeding: safety notes
- Raynaud's
- Recurring UTIs
- Sexual function & libido (women and men)
- Sleep apnea (obstructive)
- Sleep problems (incl. insomnia on peptides)
Related compounds
- ACTH (Corticotropin)
- BNP (Nesiritide)
- Endothelin-1
- L-Carnitine
- Parathyroid Hormone (PTH 1-84)
- ANP (Atrial Natriuretic Peptide)
- Angiotensin II
- Vasopressin
- Insulin (regular human)
- Calcitonin
FAQ
What is Adrenomedullin?
A 52-amino-acid peptide that widens blood vessels; studied as an infusion in heart, lung and gut conditions.
How many registered human trials study Adrenomedullin?
The PeptideWhiz trial index lists 7 registered trials for Adrenomedullin, the most recent from 2026.
How much published research exists on Adrenomedullin?
The PeptideWhiz paper index links 243 PubMed papers to Adrenomedullin; by study type, 265 human and 30 animal studies.
Which conditions is Adrenomedullin researched for?
Anxiety and panic, Atherosclerosis, cardiovascular disease & high blood pressure, Candida & persistent bacterial infections, Chronic and systemic inflammation, Concussion, traumatic brain injury & stroke recovery, Fat loss, obesity & body recomposition, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Lung health, asthma & COPD, Migraine, PCOS, Post-surgical inflammation and surgery recovery, POTS and dysautonomia, Pregnancy and breastfeeding: safety notes, Raynaud's, Recurring UTIs, Sexual function & libido (women and men), Sleep apnea (obstructive), Sleep problems (incl. insomnia on peptides).
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).