What is 5-Amino-1MQ?
A cell-permeable small molecule (not a peptide) that blocks the enzyme NNMT.
5-Amino-1MQ in the library · Metabolic & Weight Peptides · Human Trials · What are peptides?
0 registered trials · 0 indexed papers · 6 human / 2 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A cell-permeable small molecule (not a peptide) that blocks the enzyme NNMT.
Mechanism (as described)
- Blocking NNMT keeps NAD+ from draining.
- Forces fat cells to burn rather than store energy, which helps with stubborn fat.
- Insulin resistance overdrives NNMT, so this is the first step in the cognitive-decline sequence before NAD+.
More cited research
- NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bl (2024, human observational)
- Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells (2021, human observational)
- 1H NMR structural analysis of human ghrelin and its six truncated analogs (2001, human observational)
- Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor (1987, human observational)
- Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice (2022, animal)
- A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide (1989, animal)
Conditions researched
Related compounds
- L-Carnitine
- Cyanocobalamin (Vitamin B12)
- Liraglutide
- Retatrutide
- ACTH (Corticotropin)
- Amylin (Islet Amyloid Polypeptide)
- BNP (Nesiritide)
- BPC-157
- CRH (Corticotropin-Releasing Hormone)
- Cardarine (GW501516, non-peptide)
FAQ
What is 5-Amino-1MQ?
A cell-permeable small molecule (not a peptide) that blocks the enzyme NNMT.
How many registered human trials study 5-Amino-1MQ?
The PeptideWhiz trial index lists 0 registered trials for 5-Amino-1MQ.
How much published research exists on 5-Amino-1MQ?
By study type, PeptideWhiz counts 6 human and 2 animal studies on 5-Amino-1MQ.
Which conditions is 5-Amino-1MQ researched for?
Fat loss, obesity & body recomposition, Dementia, Alzheimer's & cognitive decline, Multiple sclerosis.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).