What is Argireline (Acetyl Hexapeptide-3/8)?
A topical hexapeptide that mimics part of SNAP-25 to soften expression lines; tested in small randomized cosmetic trials.
Argireline (Acetyl Hexapeptide-3/8) in the library · Cosmetic & Skin Peptides · Human Trials · What are peptides?
0 registered trials · 3 indexed papers
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
Argireline is described as a six-amino-acid cosmetic peptide; SNAP-8 (its eight-amino-acid relative) has its own page.
Mechanism (as described)
- It competes with SNAP-25 in the SNARE complex, reducing neurotransmitter release at nerve endings in lab models.
Evidence (as described)
- A randomized placebo-controlled study in Chinese adults reported reduced wrinkle depth (Wang et al., 2013). A 2025 review discusses limited skin penetration (Zdrada-Nowak et al., 2025).
Status
Cosmetic ingredient.
Peer-reviewed studies (3)
| Paper | Authors | Journal | Year | Type |
|---|---|---|---|---|
| The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study | Raikou V et al. | Journal of cosmetic dermatology | 2017 | Randomized Controlled Trial |
| The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study | Wang Y et al. | American journal of clinical dermatology | 2013 | Randomized Controlled Trial |
| Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy | Lungu C et al. | European journal of neurology | 2013 | Randomized Controlled Trial |
Related compounds
- GHK (Copper-Free)
- Matrixyl (Palmitoyl Pentapeptide-4)
- Tripeptide-29 (Collagen Tripeptide)
- ACE-031
- ACTH (Corticotropin)
- AHK-Cu
- ANP (Atrial Natriuretic Peptide)
- Adrenomedullin
- Alpha-MSH
- Amycretin
FAQ
What is Argireline (Acetyl Hexapeptide-3/8)?
A topical hexapeptide that mimics part of SNAP-25 to soften expression lines; tested in small randomized cosmetic trials.
How many registered human trials study Argireline (Acetyl Hexapeptide-3/8)?
The PeptideWhiz trial index lists 0 registered trials for Argireline (Acetyl Hexapeptide-3/8).
How much published research exists on Argireline (Acetyl Hexapeptide-3/8)?
The PeptideWhiz paper index links 3 PubMed papers to Argireline (Acetyl Hexapeptide-3/8).
Which conditions is Argireline (Acetyl Hexapeptide-3/8) researched for?
No condition pages are linked to this compound yet.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).