What is Tripeptide-29 (Collagen Tripeptide)?

The collagen tripeptide Gly-Pro-Hyp, used in cosmetics and oral collagen supplements for skin hydration and elasticity.

Tripeptide-29 (Collagen Tripeptide) in the library · Cosmetic & Skin Peptides · Human Trials · What are peptides?

0 registered trials · 7 indexed papers

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Tripeptide-29 is described as the cosmetic name for the collagen-derived tripeptide glycine-proline-hydroxyproline.

Mechanism (as described)

  • Oral collagen tripeptide is absorbed partly intact, and Gly-Pro-Hyp appears in blood and urine (Yamamoto et al., 2016).

Evidence (as described)

  • A randomized, placebo-controlled trial of a low-molecular-weight collagen peptide reported better skin hydration and elasticity (Kim et al., 2018). Oral collagen is reviewed by Choi et al., 2019.

Status

Cosmetic and supplement ingredient.

Peer-reviewed studies (7)

PaperAuthorsJournalYearType
Liposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled TrialLin YK et al.Journal of cosmetic dermatology2026Randomized Controlled Trial
Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled StudyKim DU et al.Nutrients2018Randomized Controlled Trial
Anti-inflammatory effect of collagen tripeptide in atopic dermatitisHakuta A et al.Journal of dermatological science2017Randomized Controlled Trial
Absorption and Urinary Excretion of Peptides after Collagen Tripeptide Ingestion in HumansYamamoto S et al.Biological & pharmaceutical bulletin2016Clinical Trial
Effect of high advanced-collagen tripeptide on wound healing and skin recovery after fractional photothermolysis treatmentChoi SY et al.Clinical and experimental dermatology2014Randomized Controlled Trial
Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled studyChoi SY et al.Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology2014Randomized Controlled Trial
Effects of topical gluco-oligosaccharide and collagen tripeptide F in the treatment of sensitive atopic skinBerardesca E et al.International journal of cosmetic science2009Randomized Controlled Trial

Conditions researched

Related compounds

FAQ

What is Tripeptide-29 (Collagen Tripeptide)?

The collagen tripeptide Gly-Pro-Hyp, used in cosmetics and oral collagen supplements for skin hydration and elasticity.

How many registered human trials study Tripeptide-29 (Collagen Tripeptide)?

The PeptideWhiz trial index lists 0 registered trials for Tripeptide-29 (Collagen Tripeptide).

How much published research exists on Tripeptide-29 (Collagen Tripeptide)?

The PeptideWhiz paper index links 7 PubMed papers to Tripeptide-29 (Collagen Tripeptide).

Which conditions is Tripeptide-29 (Collagen Tripeptide) researched for?

Eczema, Skin, hair loss, wounds & mast-cell/histamine reactivity.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).