What is Copper (Supplement)?

The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Copper (Supplement) in the library · · Human Trials · What are peptides?

2 registered trials · 257 indexed papers · 324 human / 93 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What the Notes Say

Educational notes on Copper (Supplement), restating how it is described in research notes. Not guidance for any person.

  • The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
  • The copper ion in GHK-Cu is described as highly reactive, a transition metal.
  • Copper is described as catalyzing oxidation reactions that can damage other fragile peptides, especially BPC-157 or ipamorelin, when they are mixed with it.

Registered human trials (2)

TrialPhaseStatusYearEnrolled
Copper Supplementation in Cirrhosisrecruiting202630
Human Biomarkers for Assessing Copper DeficiencyPhase 1unknown201070

Peer-reviewed studies (257)

PaperAuthorsJournalYearType
Serum Zinc and Selenium Are Independently Associated with Acute-Phase Inflammatory Markers in Critically Ill Patients: A Retrospective Observational StudyOh H et al.Nutrients2026Observational Study
A wound dressing with copper and silver nanoparticles versus ionic silver hydrofibre dressing for the treatment of diabetic foot ulcers: a randomised clinical trialRoosimaa M et al.Journal of wound care2026Randomized Controlled Trial
Differential regulation of endometrial receptivity markers by levonorgestrel-releasing and copper intrauterine devices: A cross-sectional studyKarakelleoğlu GJournal of gynecology obstetrics and human reproduction2026Observational Study
Prospective Comparison of (64)Copper [(64)Cu]SAR-bisPSMA vs (68)Gallium[(68)Ga] PSMA-11 PET/CT for Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy (Co-PSMA Trial)Khan S et al.European urology2026Clinical Trial, Phase II
Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical TrialMelamed E et al.Advances in wound care2026Randomized Controlled Trial
Protocol for a randomized controlled trial to evaluate the impact of daily supplementation with zinc, chromium, vitamin C, and copper on progression of prediabetes in Jakarta, IndonesiaAgustina R et al.Contemporary clinical trials2025Clinical Study
Association between dietary copper intake and cognitive function in American older adults: NHANES 2011-2014Jia W et al.Scientific reports2025Observational Study
Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational studyLu Y et al.BMC ophthalmology2025Observational Study
Effect of contraceptive methods on the vaginal microbiome and host immune factorsSerrano MG et al.Contraception2025Randomized Controlled Trial
Six-year clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A split-mouth double-blind randomized clinical trialÑaupari-Villasante R et al.Journal of dentistry2025Randomized Controlled Trial
Copper biomarkers and their relationship with parameters of insulin resistance in obese womenda Silva NC et al.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025Observational Study
Analysis of zinc and copper levels in very low birth weight infants using human milk additives: phase 1 trial findingsOliveira RG et al.Jornal de pediatria2025Randomized Controlled Trial
Prediction of (177)Lu-DOTATATE PRRT Outcome Using Multimodality Imaging in Patients with Gastroenteropancreatic Neuroendocrine Tumors: Results from a Prospective Phase II LUMEN StudyMileva M et al.Journal of nuclear medicine : official publication, Society of Nuclear Medicine2024Clinical Trial, Phase II
Efficacy and Safety of Lu-177 DOTATATE Peptide Receptor Radionuclide Therapy in Patients with Unresectable or Metastatic Neuroendocrine Tumors in KoreaShin Y et al.Targeted oncology2024Clinical Trial
Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathyFarrant J et al.Heart (British Cardiac Society)2023Clinical Study
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormonesGonzález-Domínguez Á et al.BioFactors (Oxford, England)2023Observational Study
Vitamin D Supplementation Impacts Systemic Biomarkers of Collagen Degradation and Copper Metabolism in Patients With KeratoconusLasagni Vitar RM et al.Translational vision science & technology2022Observational Study
A pro-oxidant combination of resveratrol and copper reduces chemotherapy-related non-haematological toxicities in advanced gastric cancer: results of a prospective open label phase II single-arm study (RESCU III study)Ostwal V et al.Medical oncology (Northwood, London, England)2022Clinical Trial, Phase II
A prospective head-to-head comparison of (68) Ga-NOTA-3P-TATE-RGD and (68) Ga-DOTATATE in patients with gastroenteropancreatic neuroendocrine tumoursJiang Y et al.European journal of nuclear medicine and molecular imaging2022Clinical Trial
Comparison of Ferric Sodium EDTA in Combination with Vitamin C, Folic Acid, Copper Gluconate, Zinc Gluconate, and Selenomethionine as Therapeutic Option for Chronic Kidney Disease Patients with Improvement in Inflammatory StatusGiliberti A et al.Nutrients2022Randomized Controlled Trial
Phase II trial demonstrates the efficacy and safety of individualized, dosimetry-based (177)Lu-DOTATATE treatment of NET patientsSundlöv A et al.European journal of nuclear medicine and molecular imaging2022Clinical Trial, Phase II
Dose-Limiting Bone Marrow Toxicities After Peptide Receptor Radionuclide Therapy Are More Prevalent in Women Than in MenMinczeles NS et al.Clinical nuclear medicine2022Clinical Trial, Phase II
Genital inflammatory status and the innate immune response to contraceptive initiationRadzey N et al.American journal of reproductive immunology (New York, N.Y. : 1989)2022Randomized Controlled Trial
The Effect of Contraception on Genital Cytokines in Women Randomized to Copper Intrauterine Device, Depot Medroxyprogesterone Acetate, or Levonorgestrel ImplantTanko RF et al.The Journal of infectious diseases2022Randomized Controlled Trial
Toxicity and Tolerability of (177)Lu-DOTA-TATE PRRT with a Modified Administered Activity Protocol in NETs of Variable Origin - A Phase 2 Registry StudyKhatami A et al.Current radiopharmaceuticals2022Clinical Study
Glutamine relieves the hypermetabolic response and reduces organ damage in severe burn patients: A multicenter, randomized controlled clinical trialWang ZE et al.Burns : journal of the International Society for Burn Injuries2022Randomized Controlled Trial
Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back PainFarì G et al.Endocrine, metabolic & immune disorders drug targets2022Randomized Controlled Trial
Pre-Digested Protein Enteral Nutritional Supplementation Enhances Recovery of CD4(+) T Cells and Repair of Intestinal Barrier in HIV-Infected Immunological Non-RespondersGeng ST et al.Frontiers in immunology2021Clinical Trial
Effects of Zinc Acetate Hydrate Treatment on Serum Oxidative Stress Markers in Patients with Macular DrusenMano F et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2021Clinical Trial
A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarkerKelley KC et al.BMC cancer2021Clinical Trial, Phase I

More cited research

Conditions researched

Related compounds

FAQ

What is Copper (Supplement)?

The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

How many registered human trials study Copper (Supplement)?

The PeptideWhiz trial index lists 2 registered trials for Copper (Supplement), the most recent from 2026.

How much published research exists on Copper (Supplement)?

The PeptideWhiz paper index links 257 PubMed papers to Copper (Supplement); by study type, 324 human and 93 animal studies.

Which conditions is Copper (Supplement) researched for?

Anemia, Lipedema, Skin, hair loss, wounds & mast-cell/histamine reactivity, Acne, Anti-aging & longevity, Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Cognition, focus & brain performance, Concussion, traumatic brain injury & stroke recovery, Dementia, Alzheimer's & cognitive decline, Eczema, Eyes: macular degeneration & retinal health, Fat loss, obesity & body recomposition, Gum disease (periodontal) & oral health, Heart repair: after heart attack, heart failure & enlarged heart, Hemorrhoids and fissures, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Lung health, asthma & COPD, Lupus (SLE), Neuropathy and CRPS, Osteoarthritis, cartilage loss & avoiding joint replacement, Osteoporosis and bone density, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Rheumatoid arthritis, Thick blood and blood clots.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research