What is Deslorelin?
A potent GnRH agonist used as a slow-release implant in veterinary medicine (Suprelorin) to suppress reproduction and treat ferret adrenal disease.
Deslorelin in the library · · Human Trials · What are peptides?
3 registered trials · 9 indexed papers · 10 human / 11 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
Deslorelin is described as a synthetic GnRH analog much more potent and longer-lasting than natural GnRH.
Mechanism (as described)
- Constant exposure first stimulates and then shuts down LH and FSH release, lowering sex hormones.
Evidence (as described)
- Veterinary studies report delayed puberty in cats (Risso et al., 2012) and control of adrenocortical disease in ferrets (Wagner et al., 2005). Human use is limited to early research.
Status
Veterinary-approved implants (Suprelorin). Not approved for human use.
Registered human trials (3)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease | Phase 2 | unknown | 2004 | 11 |
| Treatment of Boys With Precocious Puberty | Phase 2 | completed | 1985 | 80 |
| Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature | Phase 2 | completed | 1983 | 50 |
Peer-reviewed studies (9)
More cited research
- Effect of a deslorelin implant in a timed artificial insemination protocol on follicle development, luteal function and reproductive performance of lactating da (2004, animal)
- GnRH analogs induce a LH peak and increase pregnancy per timed-AI in ewes (2024, animal)
- Pre-pubertal treatment with a GnRH agonist in bitches-Effect on the uterus and hormone receptor expression (2018, animal)
- Influence of exogenous gonadotropin-releasing hormone on seasonal reproductive behavior of the coyote (Canis latrans) (2009, animal)
Conditions researched
Related compounds
- Cetrorelix
- Degarelix
- Elagolix (non-peptide)
- ACTH (Corticotropin)
- Buserelin
- CGRP (Calcitonin Gene-Related Peptide)
- Calcitonin
- Carbetocin
- GHK (Copper-Free)
- Glucagon
FAQ
What is Deslorelin?
A potent GnRH agonist used as a slow-release implant in veterinary medicine (Suprelorin) to suppress reproduction and treat ferret adrenal disease.
How many registered human trials study Deslorelin?
The PeptideWhiz trial index lists 3 registered trials for Deslorelin, the most recent from 2004.
How much published research exists on Deslorelin?
The PeptideWhiz paper index links 9 PubMed papers to Deslorelin; by study type, 10 human and 11 animal studies.
Which conditions is Deslorelin researched for?
Endometriosis.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).