What is hCG (human chorionic gonadotropin)?

An LH analog that drives Leydig-cell testosterone production.

hCG (human chorionic gonadotropin) in the library · · Human Trials · What are peptides?

263 registered trials · 1335 indexed papers · 1842 human / 94 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

An LH analog that drives Leydig-cell testosterone production.

Registered human trials (263)

TrialPhaseStatusYearEnrolled
hCG Treatment for Rehabilitation From a TBIEARLY_Phase 1not yet recruiting202750
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Respondersrecruiting2026100
FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cyclesrecruiting2026120
hCG Priming in Women With Diminished Ovarian ReservePhase 3recruiting202680
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)Phase 3recruiting2026266
Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantageenrolling by invitation2026360
Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cyclerecruiting202640
The Application of HCG in Luteal Support for Frozen Embryo Transfer in Ovulation Cycle of Obese Womennot yet recruiting2026750
Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletesenrolling by invitation202660
Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG TriggerPhase 2not yet recruiting2026164
Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG TriggerPhase 2not yet recruiting2026196
Isotretinoin vs hCG for Male Infertility Due to Low or Absent SpermPhase 2enrolling by invitation2026100
Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructivenot yet recruiting2026860
Comparison of Beta-hCG Levels When Using Venous Puncture Blood and Peripheral Finger Stick Bloodnot yet recruiting202640
Comparison of Dydrogesterone Alone Versus Dydrogesterone Plus HCG in Threatened Miscarriagecompleted2025100
Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Inseminationrecruiting2025692
Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer CyclesPhase 4recruiting2025180
The Role of hCG in Thawed Embryo TransferPhase 4recruiting2025220
Sleep Quality and the Menstrual Cycleactive not recruiting202560
Efficacy of Human Chorionic Gonadotropin in Acute GVHD TreatmentPhase 2recruiting202520
Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET)Phase 4recruiting2025334
The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles .Phase 1not yet recruiting202560
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)Phase 3recruiting2024126
Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE GroupsPhase 4enrolling by invitation2024500
MIRA CONNECT Studyrecruiting202435
Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI CyclesPhase 3recruiting2024652
Effect of HCG on Endometrial Preparation in Frozen Embryo Transferunknown202450
Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertilityunknown202490
Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter SyndromePhase 3recruiting2023150
Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated CorticosteroidsPhase 1/Phase 2terminated202310
Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation InductionPhase 3completed202360
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase SupportPhase 1recruiting2023342
To Investigate Efficacy and Safety of a Single Injection of GenSci094 for Ovarian Stimulation Using Daily Recombinant FSH as ReferencePhase 3completed2023176
HUMAN CHORIONIC GONADOTROPIN (HcG) VS MAGNESIUM SULPHATE (MgSo4) AS A TOCOLYTIC AGENT- A RANDOMIZED CONTROLLED TRIALcompleted202370
Triggering Oocyte Maturation in Normoresponders Using Double Trigger or HCG TriggerPhase 2unknown2023150
The Effect of Dual Trigger (GnRH Agonist + hCG) for Final Maturation in Oocyte Donors With History of a Previous Cycle With Suboptimal Response to GnRH Agonist Only Triggerunknown202380
Investigation of the Effects of Telerehabilitation Groups for Chronic Non-specific Low Back Pain.completed202372
Effects of Intrauterine Flushing With Human Chorionic Gonadotropin on ICSI OutcomePhase 4completed202290
Letrozole Alone Protocol Versus Using Letrozole and HCG ProtocolPhase 1completed2022132
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism MenPhase 2unknown202232

Peer-reviewed studies (1335)

PaperAuthorsJournalYearType
Corifollitropin alfa N02 versus recombinant FSH for ovarian stimulation: a phase 3 trial and safety study in Chinese womenLi T et al.Reproductive biomedicine online2026Randomized Controlled Trial
Association of human chorionic gonadotropin and post-pregnancy persistent enhanced myometrial vascularityTimor-Tritsch IE et al.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2026Observational Study
An injection-lite approach to ovarian stimulation in poor responder patients using corifollitropin alfa and nasal GnRH agonistArulpragasam K et al.Journal of assisted reproduction and genetics2026Randomized Controlled Trial
Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trialKonsam BD et al.Frontiers in endocrinology2026Randomized Controlled Trial
Protocol for a prospective observational cohort study to assess clinical applications of expanded noninvasive prenatal testing (NIPT) in pregnancies with placental dysfunctionVillalba A et al.PloS one2026Clinical Study
Hysteroscopy Contribution in Unlocated Pregnancy Localization, Diagnosis, and ManagementMeiranesio E et al.Journal of minimally invasive gynecology2026Observational Study
Risk of progesterone elevation in patients with low ovarian reserve using long-acting FSH IVF protocol: a randomized controlled trialPapaleo E et al.Reproductive biomedicine online2026Randomized Controlled Trial
Comparative efficacy of human chorionic gonadotropin alone versus dual trigger for oocyte maturation in advanced maternal age using the antagonist protocol: a randomized controlled trialThanaboonyawat I et al.Journal of ovarian research2026Randomized Controlled Trial
Expectant management of tubal ectopic pregnancy: Updated decision tree analysis for the prediction of successful outcomesGraham N et al.European journal of obstetrics, gynecology, and reproductive biology2026Observational Study
Nonlinear association of serum luteinizing hormone on hCG trigger day with cumulative live birth in IVF cycles: secondary analysis of a randomized clinical trialGuo L et al.Journal of assisted reproduction and genetics2026Randomized Controlled Trial
Impact of Follicle Size at Trigger on Reproductive Outcomes in Letrozole-Modified Natural Frozen Embryo Transfer Cycles in High Responder PatientsPabuccu E et al.Journal of assisted reproduction and genetics2026Observational Study
Experience in medical treatment of ectopic pregnancy, cesarean scar with three comparative methods: Methotrexate intra-gestational-sac injection, ultrasound-guided KCL injection, and hysteroscopy-assisted resectionNavali N et al.Journal of gynecology obstetrics and human reproduction2026Randomized Controlled Trial
Clinical Pregnancy Rate in Intrauterine Insemination and Associated Prognostic FactorsSharma A et al.Annals of African medicine2026Observational Study
Dual trigger vs. gonadotropin-releasing hormone agonist trigger for elective fertility preservation: a randomized controlled trialDonno V et al.Fertility and sterility2026Randomized Controlled Trial
Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort StudyXin XY et al.Chinese journal of integrative medicine2025Randomized Controlled Trial
[Restoration of ejaculate quality following androgen replacement and combined therapy for hypogonadism]Rozhivanova ER et al.Problemy endokrinologii2025Observational Study
Impact of fetal sex on first trimester markers of placental development and pregnancy outcome: a prospective cohort studyParisi F et al.European journal of obstetrics, gynecology, and reproductive biology2025Observational Study
Mate Whenua-follow-up after early medical abortion: study protocol for a randomized controlled trialWise MR et al.Trials2025Clinical Study
Application of Cyclosporine A Plus Zishen Yutai Pill in the Treatment of Patients with Recurrent Pregnancy LossZhang M et al.Journal of investigative surgery : the official journal of the Academy of Surgical Research2025Randomized Controlled Trial
Scoring prognostic factors for pregnancy post-intrauterine insemination in couples with infertilityLaurus G et al.The Pan African medical journal2025Observational Study
Maternal first trimester SIMPLE nutritional score, early markers of placental function and pregnancy outcome: a prospective multicenter Italian study (SIMPLE study)Parisi F et al.European journal of clinical nutrition2025Observational Study
Change in hCG levels after very early medication abortion for pregnancy of unknown location or probable intrauterine pregnancyJar-Allah T et al.Contraception2025Randomized Controlled Trial
Randomized controlled trial to evaluate the impact of follicle priming on IVM outcomes in women with polycystic ovaries: CFA versus FSH-BDe Vos M et al.Human reproduction (Oxford, England)2025Randomized Controlled Trial
Comparison of outcomes between pulsatile gonadotropin releasing hormone and combined gonadotropin therapy of spermatogenesis in patients with congenital hypogonadotropic hypogonadismZheng Y et al.Reproductive biology and endocrinology : RB&E2025Clinical Trial
The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening MarkersMurvai VR et al.Medicina (Kaunas, Lithuania)2025Observational Study
Managing Pregnancies of Unknown Location With the M4 Prediction Model or the NICE Algorithm: A Randomised Controlled Trial With Cross-Sectional Diagnostic Accuracy DataFistouris J et al.BJOG : an international journal of obstetrics and gynaecology2025Randomized Controlled Trial
Evaluating single-dose methotrexate alone versus methotrexate with letrozole for treating ectopic pregnancy: a comparative studyAyğar M et al.Archives of gynecology and obstetrics2025Randomized Controlled Trial
Local and systemic methotrexate in management of caesarean scar pregnancyToutain T et al.European journal of obstetrics, gynecology, and reproductive biology2025Observational Study
Efficacy of uterine flushing with human chorionic gonadotropin (hCG) on pregnancy rates in primary unexplained infertility: a randomized controlled trialHakimi P et al.European journal of medical research2024Randomized Controlled Trial
The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational studyHokmabadi E et al.BMC women's health2024Observational Study

More cited research

Conditions researched

Related compounds

FAQ

What is hCG (human chorionic gonadotropin)?

An LH analog that drives Leydig-cell testosterone production.

How many registered human trials study hCG (human chorionic gonadotropin)?

The PeptideWhiz trial index lists 263 registered trials for hCG (human chorionic gonadotropin), the most recent from 2027.

How much published research exists on hCG (human chorionic gonadotropin)?

The PeptideWhiz paper index links 1335 PubMed papers to hCG (human chorionic gonadotropin); by study type, 1842 human and 94 animal studies.

Which conditions is hCG (human chorionic gonadotropin) researched for?

Low testosterone (without or alongside TRT), Male fertility and sperm, Anemia, Anti-aging & longevity, Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Concussion, traumatic brain injury & stroke recovery, Endometriosis, Fat loss, obesity & body recomposition, Female fertility, High cholesterol and statins, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Menopause & perimenopause, Migraine, Osteoporosis and bone density, PCOS, PMDD (premenstrual dysphoric disorder), Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Prostate inflammation, Sleep problems (incl. insomnia on peptides), Thick blood and blood clots, Thyroid problems.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research