What is Triptorelin?

A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.

Triptorelin in the library · · Human Trials · What are peptides?

205 registered trials · 465 indexed papers · 507 human / 4 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.

Type: GnRH analog peptide.

Definition (National Library of Medicine)

“A potent synthetic long-acting agonist of gonadotropin-releasing hormone with D-tryptophan substitution at residue 6.”

  • MeSH: Triptorelin Pamoate

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Triptorelin is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (205)

TrialPhaseStatusYearEnrolled
Evaluating Hormone Therapy to Achieve Optimal Doses in Metastatic Prostate CancerPhase 3recruiting20261500
Intranasal Nafarelin For Triggering Oocyte MaturationPhase 4recruiting2026154
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Respondersrecruiting2026100
QL1706 Plus Neoadjuvant Endocrine Therapy in HR-Positive/HER2-Negative Breast Cancer With a Poor Response to Neoadjuvant ChemotherapyPhase 2not yet recruiting202640
Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CTPhase 2recruiting202650
Supraphysiologic Testosterone Priming Induces Darolutamide Extended ResponsePhase 2recruiting202660
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With CancerPhase 3recruiting202560
Ultra-Long GnRH-a Pretreatment for FET Outcomes in Patients With Deep Infiltrating EndometriosisPhase 4recruiting2025120
The COSMYC Trial (COmbined Suppression of MYC)Phase 2recruiting202550
Adaptive Androgen Deprivation and Docetaxel in Metastatic Castration Sensitive Prostate CancerPhase 2active not recruiting202525
COMPASS - COpenhagen MenoPAuSe StudyPhase 2recruiting2025192
Pembrolizumab With Androgen Deprivation Therapy and Radiotherapy for the Treatment of Patients With High Risk Localized Prostate CancerPhase 2withdrawn2025
Efficacy, Safety, and Pharmacokinetics of FP-[amount hidden] in Patients With Advanced Prostate CancerPhase 3withdrawn2025
Efficacy, Safety, and Pharmacokinetics of FP-[amount hidden] in Patients With Advanced Prostate CancerPhase 3withdrawn2025
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)Phase 3recruiting2024126
Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE TrialPhase 2recruiting2024532
A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast CancerPhase 2completed2024231
Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI CyclesPhase 3recruiting2024652
Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatmentrecruiting2024590
Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer PatientsPhase 2recruiting2024124
Effect GnRH Agonist Administration in Endometriosis Cyst PatientsPhase 3recruiting202432
Study on Human Bioequivalence of Triprerelin Acetate for InjectionPhase 1recruiting2024120
Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPPPhase 4not yet recruiting2024134
Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertilityunknown202490
Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene AlterationsPhase 2active not recruiting202332
Elacestrant With/Without Triptorelin in Premenopausal Women With Luminal Breast CancerPhase 2recruiting202396
Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular TracersPhase 2/Phase 3recruiting2023493
Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finlandcompleted20231083
Difluoromethylornithine and High Dose Testosterone With Enzalutamide in Metastatic Castration-Resistant Prostate CancerPhase 2recruiting202350
Adenomyosis and Pregnancy: Levonorgestrel vs. GnRH for Blastocyst Transfercompleted2023184
Dose Escalation For INtraprostatic LEsionsPhase 2recruiting202354
Short Versus Long-term Androgen Deprivation Therapy With Salvage Radiotherapy in Prostate Cancer. URONCOR 0624Phase 3recruiting2023534
Use of GnRHa During Chemotherapy for Fertility ProtectionPhase 3recruiting2023500
Dydrogesterone, Cetrorelix Acetate and Triptorelin in Intra Cytoplasmic Sperm Injection OutcomesPhase 3unknown2023387
First Strike, Second Strike Therapies for High Risk Metastatic Castration Sensitive Prostate CancerPhase 2active not recruiting202232
Effects of Triptorelin Pamoate 6-month When Given to Adult Chinese Participants With Advanced Cancer in the ProstatePhase 3completed2022195
Effects of Triptorelin When Given Every 6-months Under the Skin to Adult Males With Cancer in the ProstatePhase 3completed2022147
Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase SupportPhase 4completed202275
Triptorelin for Early Diagnosis of Hypogonadotrophic Hypogonadismunknown202248
DEPO-Trigger Trial: GnRH Agonist DEPOt TRIGGER for Final Oocyte MaturationPhase 1/Phase 2unknown202230

Peer-reviewed studies (465)

PaperAuthorsJournalYearType
[Efficacy and safety of triptorelin acetate microspheres for injection versus triptorelin acetate for injection in Chinese patients with endometriosis: a multicenter, randomized, double-blind, phase Ⅲ non-inferiority clinical trial]Zhao AM et al.Zhonghua fu chan ke za zhi2026Randomized Controlled Trial
Efficacy of Huayu Xiaozheng decoction combined with triptorelin and mifepristone in the treatment of uterine fibroids and its effect on uterine artery hemodynamicsZhou Y et al.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026Randomized Controlled Trial
Dual trigger vs. gonadotropin-releasing hormone agonist trigger for elective fertility preservation: a randomized controlled trialDonno V et al.Fertility and sterility2026Randomized Controlled Trial
Clinical efficacy and influence on the quality of life of children with precocious puberty treated by combination of cluster nursing and triptorelinWang H et al.Medicine2025Randomized Controlled Trial
Short-term Androgen Deprivation Therapy and High-dose Radiotherapy in Intermediate- and High-risk Localized Prostate Cancer: Results from the GETUG 14 Randomized Phase 3 TrialDemogeot N et al.European urology2025Randomized Controlled Trial
Ten-year update of HOBOE phase III trial comparing triptorelin plus either tamoxifen or letrozole or zoledronic acid + letrozole in premenopausal hormone receptor-positive early breast cancer patientsGravina A et al.ESMO open2025Randomized Controlled Trial
Adult height in girls with idiopathic central precocious puberty treated with triptorelinCorripio R et al.Frontiers in endocrinology2024Observational Study
A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious PubertyYu X et al.Advances in therapy2024Clinical Trial, Phase III
PRIORITI: Phase 4 study of triptorelin or active surveillance in high-risk prostate cancerMatveev V et al.Asia-Pacific journal of clinical oncology2024Randomized Controlled Trial
Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricalsAbbara A et al.Fertility and sterility2024Randomized Controlled Trial
Efficacy and safety of diphereline [amount hidden], microrelin [amount hidden], and microrelin [amount hidden] in premenopausal patients with breast cancer: a non-inferiority randomized clinical trialNajafi S et al.BMC cancer2023Randomized Controlled Trial
Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender PersonsTebbens M et al.The Journal of clinical endocrinology and metabolism2023Randomized Controlled Trial
Endocrine Responses to Triptorelin in Healthy Women, Women With Polycystic Ovary Syndrome, and Women With Hypothalamic AmenorrheaAbbara A et al.The Journal of clinical endocrinology and metabolism2023Randomized Controlled Trial
Phase I Study of Androgen Deprivation Therapy in Combination with Anti-PD-1 in Melanoma Patients Pretreated with Anti-PD-1Robert C et al.Clinical cancer research : an official journal of the American Association for Cancer Research2023Clinical Trial, Phase I
Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled TrialLi X et al.Advances in therapy2022Randomized Controlled Trial
Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cyclesZhou C et al.Human reproduction (Oxford, England)2022Randomized Controlled Trial
Single-administered GnRH agonist as luteal phase support in insemination cycles: a randomized controlled trialLeppänen R et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2022Randomized Controlled Trial
The efficacy and safety of triptorelin-therapy following conservative surgery for deep infiltrating endometriosis: A multicenter, prospective, non-interventional study in ChinaZhu L et al.Medicine2022Observational Study
Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious pubertyShokri E et al.Lipids in health and disease2021Randomized Controlled Trial
Dienogest vs GnRH agonists as postoperative therapy after laparoscopic eradication of deep infiltrating endometriosis with bowel and parametrial surgery: a randomized controlled trialCeccaroni M et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2021Randomized Controlled Trial
Fixed versus flexible antagonist protocol in women with predicted high ovarian response except PCOS: a randomized controlled trialLuo X et al.BMC pregnancy and childbirth2021Randomized Controlled Trial
Angiogenic cytokine and interleukin 8 levels in early luteal phase after triggering ovulation with gonadotropin-releasing hormone agonist in high-responder patientsMartazanova B et al.American journal of reproductive immunology (New York, N.Y. : 1989)2021Observational Study
Pregnancy outcome and cost-effectiveness comparisons of artificial cycle-prepared frozen embryo transfer with or without GnRH agonist pretreatment for polycystic ovary syndrome: a randomised controlled trialLuo L et al.BJOG : an international journal of obstetrics and gynaecology2021Randomized Controlled Trial
Bone Development in Transgender Adolescents Treated With GnRH Analogues and Subsequent Gender-Affirming HormonesSchagen SEE et al.The Journal of clinical endocrinology and metabolism2020Observational Study
Triptorelin for the treatment of adenomyosis: A multicenter observational study of 465 women in RussiaAndreeva E et al.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2020Observational Study
Effect of GnRH agonist before IVF on outcomes in infertile endometriosis patients: a randomized controlled trialRodríguez-Tárrega E et al.Reproductive biomedicine online2020Randomized Controlled Trial
Relapse after conservative surgery combined with triptorelin acetate versus conservative surgery only in women with focal adenomyosis: study protocol for a multicenter, prospective, randomized controlled trialWang W et al.Trials2020Clinical Study
A prospective, single-centre, single-arm, open label study of the long term use of a gonadotropin releasing hormone agonist (Triptorelin SR, [amount hidden]) in combination with Tibolone add-back therapy in the management of chronic cyclical pelvic painAlshehre SM et al.Reproductive biology and endocrinology : RB&E2020Clinical Trial
Association between body mass index and oocyte maturation in patients triggered with GnRH agonist who are at high risk for severe ovarian hyperstimulation syndrome: an observational cohort studyLainas GT et al.Reproductive biomedicine online2020Observational Study
GnRH agonists to sustain the luteal phase in antagonist IVF cycles: a randomized prospective trialFusi FM et al.Reproductive biology and endocrinology : RB&E2019Randomized Controlled Trial

More cited research

Conditions researched

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FAQ

What is Triptorelin?

A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.

How many registered human trials study Triptorelin?

The PeptideWhiz trial index lists 205 registered trials for Triptorelin, the most recent from 2026.

How much published research exists on Triptorelin?

The PeptideWhiz paper index links 465 PubMed papers to Triptorelin; by study type, 507 human and 4 animal studies.

Which conditions is Triptorelin researched for?

Endometriosis, Fat loss, obesity & body recomposition, Fatigue & low energy (incl. midlife), Fatty liver & elevated liver enzymes, Female fertility, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Low testosterone (without or alongside TRT), Lupus (SLE), Male fertility and sperm, Menopause & perimenopause, Osteoporosis and bone density, PCOS, PMDD (premenstrual dysphoric disorder), Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Sleep problems (incl. insomnia on peptides).

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research