What is Kisspeptin-54?

The full-length 54-amino-acid kisspeptin, studied in people to trigger egg maturation in IVF; Kisspeptin-10 has its own page.

Kisspeptin-54 in the library · · Human Trials · What are peptides?

1 registered trials · 22 indexed papers · 58 human / 68 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Kisspeptin-54 is described as the main circulating form of kisspeptin; kisspeptin-10 is its active C-terminal end.

Mechanism (as described)

  • It activates the KISS1R receptor on GnRH neurons, releasing LH and FSH.

Evidence (as described)

  • Human studies used it to trigger egg maturation in IVF and to study reproductive hormones (Abbara et al., 2020; Mills et al., 2025).

Status

Investigational.

Registered human trials (1)

TrialPhaseStatusYearEnrolled
The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) TreatmentPhase 2completed2012175

Peer-reviewed studies (22)

PaperAuthorsJournalYearType
Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humansMills EG et al.EBioMedicine2025Randomized Controlled Trial
Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in HumansMills EG et al.The Journal of clinical endocrinology and metabolism2025Randomized Controlled Trial
Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricalsAbbara A et al.Fertility and sterility2024Randomized Controlled Trial
Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical TrialMills EG et al.JAMA network open2023Randomized Controlled Trial
Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical TrialThurston L et al.JAMA network open2022Randomized Controlled Trial
Kisspeptin receptor agonist has therapeutic potential for female reproductive disordersAbbara A et al.The Journal of clinical investigation2020Clinical Trial
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndromeRomero-Ruiz A et al.Human reproduction (Oxford, England)2019Clinical Trial
The direct and indirect effects of kisspeptin-54 on granulosa lutein cell functionOwens LA et al.Human reproduction (Oxford, England)2018Clinical Trial
A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trialAbbara A et al.Human reproduction (Oxford, England)2017Randomized Controlled Trial
Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levelsNarayanaswamy S et al.Clinical endocrinology2016Clinical Trial
Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) TherapyAbbara A et al.The Journal of clinical endocrinology and metabolism2015Randomized Controlled Trial
Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilizationJayasena CN et al.The Journal of clinical investigation2014Clinical Trial
Acute and chronic effects of kisspeptin-54 administration on GH, prolactin and TSH secretion in healthy womenJayasena CN et al.Clinical endocrinology2014Clinical Trial
Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studiesMacLean DB et al.The Journal of clinical endocrinology and metabolism2014Randomized Controlled Trial
Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of Kisspeptin-54Jayasena CN et al.The Journal of clinical endocrinology and metabolism2014Controlled Clinical Trial
Twice-daily subcutaneous injection of kisspeptin-54 does not abolish menstrual cyclicity in healthy female volunteersJayasena CN et al.The Journal of clinical endocrinology and metabolism2013Controlled Clinical Trial
A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy womenJayasena CN et al.Clinical endocrinology2013Clinical Trial
Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrheaJayasena CN et al.Clinical pharmacology and therapeutics2010Randomized Controlled Trial
Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxisJayasena CN et al.The Journal of clinical endocrinology and metabolism2009Randomized Controlled Trial
An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivoKeen KL et al.Endocrinology2008Randomized Controlled Trial
Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in womenDhillo WS et al.The Journal of clinical endocrinology and metabolism2007Clinical Trial
Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human malesDhillo WS et al.The Journal of clinical endocrinology and metabolism2005Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Kisspeptin-54?

The full-length 54-amino-acid kisspeptin, studied in people to trigger egg maturation in IVF; Kisspeptin-10 has its own page.

How many registered human trials study Kisspeptin-54?

The PeptideWhiz trial index lists 1 registered trial for Kisspeptin-54, the most recent from 2012.

How much published research exists on Kisspeptin-54?

The PeptideWhiz paper index links 22 PubMed papers to Kisspeptin-54; by study type, 58 human and 68 animal studies.

Which conditions is Kisspeptin-54 researched for?

Anxiety and panic, Female fertility, PCOS, Sexual function & libido (women and men).

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).