What is Endothelin-1?
A 21-amino-acid peptide and one of the strongest blood-vessel constrictors in the body; given in research studies of vascular function.
Endothelin-1 in the library · · Human Trials · What are peptides?
4 registered trials · 750 indexed papers · 826 human / 167 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A 21-amino-acid peptide and one of the strongest blood-vessel constrictors in the body; given in research studies of vascular function.
Type: Peptide.
Definition (National Library of Medicine)
“A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)”
- MeSH: Endothelin-1
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Endothelin-1 is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (4)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Prenatal Aspirin and Postpartum Vascular Function | EARLY_Phase 1 | recruiting | 2023 | 60 |
| Endothelin-1 as a Potential Trigger of Migraine Aura | unknown | 2016 | 60 | |
| Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3) | EARLY_Phase 1 | completed | 2009 | 10 |
| The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin | completed | 2008 | 15 |
Peer-reviewed studies (750)
More cited research
- Endopeptidase inhibition attenuates the contraction induced by big endothelin-1 of isolated human penile erectile tissue (2018, human observational)
- Effect of cigarette smoking and nicotine on plasma endothelin-1 levels (1995, human observational)
- 17beta-estradiol decreases endothelin-1 levels in the coronary circulation of postmenopausal women with coronary artery disease (None, human trial (non-randomized))
- A causal role for endothelin-1 in the vascular adaptation to skeletal muscle deconditioning in spinal cord injury (None, human trial (non-randomized))
- Involvement of endothelin B receptors in the endothelin-3-induced increase of ghrelin and growth hormone in Holstein steers (2010, animal)
- Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in iso (2008, animal)
- Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in (2004, animal)
- Local distributions of oviductal estradiol, progesterone, prostaglandins, oxytocin and endothelin-1 in the cyclic cow (1998, animal)
Conditions researched
- Anxiety and panic
- Atherosclerosis, cardiovascular disease & high blood pressure
- Candida & persistent bacterial infections
- Chronic and systemic inflammation
- Chronic pain: fibromyalgia & CRPS
- Concussion, traumatic brain injury & stroke recovery
- Dementia, Alzheimer's & cognitive decline
- Diabetic retinopathy and glaucoma
- Fat loss, obesity & body recomposition
- Fatty liver & elevated liver enzymes
- Gout
- Gum disease (periodontal) & oral health
- Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers
- Heart repair: after heart attack, heart failure & enlarged heart
- High cholesterol and statins
- High-demand jobs: military, fire, police, EMT (and combat-sport athletes)
- High ferritin and iron overload
- Immune system (general)
- Insulin resistance, prediabetes & type 2 diabetes
- Kidney protection (CKD, diabetic kidney, lupus kidney)
- Lung health, asthma & COPD
- Lupus (SLE)
- Lymphedema and swelling
- Menstrual cramps (dysmenorrhea)
- Migraine
- Muscle gain, sarcopenia & building muscle after 40
- Neuropathy and CRPS
- Osteoarthritis, cartilage loss & avoiding joint replacement
- Osteoporosis and bone density
- Pancreatitis (after the acute phase)
- PCOS
- Post-surgical inflammation and surgery recovery
- Pregnancy and breastfeeding: safety notes
- Psoriasis and psoriatic arthritis
- Raynaud's
- Rheumatoid arthritis
- Sexual function & libido (women and men)
- Skin, hair loss, wounds & mast-cell/histamine reactivity
- Sleep apnea (obstructive)
- Sleep problems (incl. insomnia on peptides)
- Thick blood and blood clots
- Varicose veins
Related compounds
- BNP (Nesiritide)
- Glutathione
- ACTH (Corticotropin)
- L-Carnitine
- Semaglutide
- BPC-157
- Insulin (regular human)
- Parathyroid Hormone (PTH 1-84)
- Vasopressin
- Calcitonin
FAQ
What is Endothelin-1?
A 21-amino-acid peptide and one of the strongest blood-vessel constrictors in the body; given in research studies of vascular function.
How many registered human trials study Endothelin-1?
The PeptideWhiz trial index lists 4 registered trials for Endothelin-1, the most recent from 2023.
How much published research exists on Endothelin-1?
The PeptideWhiz paper index links 750 PubMed papers to Endothelin-1; by study type, 826 human and 167 animal studies.
Which conditions is Endothelin-1 researched for?
Anxiety and panic, Atherosclerosis, cardiovascular disease & high blood pressure, Candida & persistent bacterial infections, Chronic and systemic inflammation, Chronic pain: fibromyalgia & CRPS, Concussion, traumatic brain injury & stroke recovery, Dementia, Alzheimer's & cognitive decline, Diabetic retinopathy and glaucoma, Fat loss, obesity & body recomposition, Fatty liver & elevated liver enzymes, Gout, Gum disease (periodontal) & oral health, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, High cholesterol and statins, High-demand jobs: military, fire, police, EMT (and combat-sport athletes), High ferritin and iron overload, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Lung health, asthma & COPD, Lupus (SLE), Lymphedema and swelling, Menstrual cramps (dysmenorrhea), Migraine, Muscle gain, sarcopenia & building muscle after 40, Neuropathy and CRPS, Osteoarthritis, cartilage loss & avoiding joint replacement, Osteoporosis and bone density, Pancreatitis (after the acute phase), PCOS, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Psoriasis and psoriatic arthritis, Raynaud's, Rheumatoid arthritis, Sexual function & libido (women and men), Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep apnea (obstructive), Sleep problems (incl. insomnia on peptides), Thick blood and blood clots, Varicose veins.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).