What is Melanotan I?
A synthetic melanotropin (α-MSH analog), afamelanotide, studied for pigmentation; the approved product is an implant.
Melanotan I in the library · Cosmetic & Skin Peptides · Human Trials · What are peptides?
23 registered trials · 15 indexed papers · 66 human / 14 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
Evidence limits (as described)
- Melanocortin research involving pigmentation is described as not eliminating ultraviolet risk, and a research vial cannot be assumed equivalent to material used in a controlled trial.
- Product identity, impurities, sterility, stability, exposure and pharmacokinetics are described as requiring formulation-specific evidence.
Registered human trials (23)
Peer-reviewed studies (15)
More cited research
- Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression (2013, human observational)
- Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease (2007, human observational)
- Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: colocalization of MT1 with vasopressin, oxytocin, and cor (2006, human observational)
- High Melatonin Conditions by Constant Darkness and High Temperature Differently Affect Melatonin Receptor mt1 and TREK Channel trek2a in the Brain of Zebrafish (2018, animal)
- Effect of nourishing and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats (2024, animal)
- Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish (2019, animal)
Conditions researched
- Acne
- Concussion, traumatic brain injury & stroke recovery
- Skin, hair loss, wounds & mast-cell/histamine reactivity
Related compounds
- Alpha-MSH
- IGF-1 LR3
- ACTH (Corticotropin)
- GHK (Copper-Free)
- GHK-Cu (Copper peptide)
- Glutathione
- BNP (Nesiritide)
- BPC-157
- Copper (Supplement)
- Cyanocobalamin (Vitamin B12)
FAQ
What is Melanotan I?
A synthetic melanotropin (α-MSH analog), afamelanotide, studied for pigmentation; the approved product is an implant.
How many registered human trials study Melanotan I?
The PeptideWhiz trial index lists 23 registered trials for Melanotan I, the most recent from 2024.
How much published research exists on Melanotan I?
The PeptideWhiz paper index links 15 PubMed papers to Melanotan I; by study type, 66 human and 14 animal studies.
Which conditions is Melanotan I researched for?
Acne, Concussion, traumatic brain injury & stroke recovery, Skin, hair loss, wounds & mast-cell/histamine reactivity.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).