What is Met-Enkephalin (Opioid Growth Factor)?
A 5-amino-acid natural opioid peptide; studied as "opioid growth factor" in a small number of trials.
Met-Enkephalin (Opioid Growth Factor) in the library · · Human Trials · What are peptides?
4 registered trials · 20 indexed papers · 78 human / 241 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A 5-amino-acid natural opioid peptide; studied as "opioid growth factor" in a small number of trials.
Type: Opioid peptide.
Definition (National Library of Medicine)
“One of the endogenous pentapeptides with morphine-like activity. It differs from leu-enkephalin by the amino acid methionine in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of beta-endorphin.”
- MeSH: Enkephalin, Methionine
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Met-Enkephalin (Opioid Growth Factor) is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (4)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Opioid Growth Factor (OGF) and Gemcitabine: Novel Treatment for Pancreatic Cancer | Phase 1 | terminated | 2009 | 4 |
| Treatment of Unresectable Hepatocellular Cancer With Opioid Growth Factor | Phase 1 | completed | 2008 | 14 |
| Treatment of Advanced Head and Neck Cancer | Phase 2 | terminated | 2008 | 5 |
| Opioid Growth Factor in Treating Patients With Advanced Pancreatic Cancer That Cannot Be Removed By Surgery | Phase 2 | completed | 2003 | 25 |
Peer-reviewed studies (20)
More cited research
- Decrease of vasoactive intestinal peptide, methionine-enkephalin, substance P and increase of neuropeptide Y immunoreactive nerve fibres in aganglionic colon of (1989, human observational)
- Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus (2011, animal)
- Gi/Go couple met-enkephalin to inhibition of cholinergic and beta-adrenergic stimulation of lacrimal secretion (2000, animal)
- PACAP activates calcium influx-dependent and -independent pathways to couple met-enkephalin secretion and biosynthesis in chromaffin cells (1998, animal)
- Assessment of volumetric sex differences in the song control nuclei HVC and RA in zebra finches by immunocytochemistry for methionine enkephalin and vasoactive (1995, animal)
Conditions researched
Related compounds
- Glutathione
- Octreotide
- Therapeutic nicotine (patch, non-peptide)
- Exenatide
- L-Carnitine
- Somatostatin
- ACTH (Corticotropin)
- Angiotensin II
- CGRP (Calcitonin Gene-Related Peptide)
- Calcitonin
FAQ
What is Met-Enkephalin (Opioid Growth Factor)?
A 5-amino-acid natural opioid peptide; studied as "opioid growth factor" in a small number of trials.
How many registered human trials study Met-Enkephalin (Opioid Growth Factor)?
The PeptideWhiz trial index lists 4 registered trials for Met-Enkephalin (Opioid Growth Factor), the most recent from 2009.
How much published research exists on Met-Enkephalin (Opioid Growth Factor)?
The PeptideWhiz paper index links 20 PubMed papers to Met-Enkephalin (Opioid Growth Factor); by study type, 78 human and 241 animal studies.
Which conditions is Met-Enkephalin (Opioid Growth Factor) researched for?
Chronic pain: fibromyalgia & CRPS, Neuropathy and CRPS, Post-surgical inflammation and surgery recovery.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).