What is Therapeutic nicotine (patch, non-peptide)?

Pure nicotine as a signaling tool, separated from smoking and vaping.

Therapeutic nicotine (patch, non-peptide) in the library · · Human Trials · What are peptides?

267 registered trials · 334 indexed papers · 1722 human / 211 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Pure nicotine as a signaling tool, separated from smoking and vaping. The bolus delivery and additives of those products are blamed for the addiction and harm.

Mechanism (as described)

  • Activates α7 nicotinic receptors, an anti-inflammatory reflex that lowers TNF-α and IL-6.
  • On blood vessels: eNOS/nitric oxide, VEGF, endothelial progenitor mobilization, new vessel growth.
  • Neuroprotection.

Additional points (as described)

  • Heart and vessels: α7 receptors on vessel lining raise nitric oxide and VEGF, mobilize progenitor cells, and lower TNF-α/IL-6.

Registered human trials (267)

TrialPhaseStatusYearEnrolled
Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation TrialPhase 4not yet recruiting2027794
Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessnessnot yet recruiting2027120
DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use PharmacotherapyPhase 2not yet recruiting2026321
iCanQuit Smoking Cessation Among Hispanic AdultsPhase 3not yet recruiting2026854
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette UsePhase 4not yet recruiting2026100
Rural Smoking Cessationrecruiting2026544
Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the EnvironmentPhase 4recruiting2026600
My Path to Quit TobaccoPhase 4recruiting20261550
Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatientsrecruiting202660
The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.not yet recruiting202680
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachiarecruiting20251000
Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking CessationPhase 4recruiting2025150
Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Studyrecruiting202580
The Avenues Study: Dual Use CessationPhase 4recruiting2024500
Semaglutide for Post-Smoking Cessation Weight ManagementPhase 2recruiting2024197
Beta-Adrenergic Modulation of Drug Cue ReactivityPhase 4recruiting202480
Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine RespondersPhase 3completed2024150
Tobacco Treatment Comparison for Cancer CarePhase 4completed202452
PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.Phase 4recruiting202414
Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessationcompleted202460
Effectiveness of Different THR Products in Adult PopulationPhase 3unknown2024258
Evaluating Smoking Cessation Interventions for PWH in South AfricaPhase 2/Phase 3recruiting2023660
Defining Neurobiological Links Between Substance Use and Mental Illnessrecruiting2023620
Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDSrecruiting2023800
Depressed Mood Improvement Through Nicotine Dosing 3Phase 2completed202340
Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) ExtensionPhase 2completed202325
Free Samples for HealthPhase 2completed20231239
Evaluation of the Electronic Cigarette Withdrawal SyndromeEARLY_Phase 1recruiting2023150
Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.Phase 3recruiting2023360
Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSDPhase 2recruiting202350
CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettesPhase 2completed202346
Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, KenyaPhase 4completed2023580
Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRTPhase 3terminated20234
Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and ZambiaPhase 1unknown2023800
Preloaded Combination Nicotine Replacement Therapy on Smoking Cessation of Adult Population in KazakhstanEARLY_Phase 1unknown2023200
Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)active not recruiting2022360
Exenatide for Smoking Cessation and Prevention of Weight GainPhase 2completed2022140
Smoking Cessation and Menstrual Cycle PhasePhase 4recruiting20221200
Mobile Health Technology for Personalized Tobacco Cessation Support in LaosPhase 2recruiting2022500
Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)Phase 1completed202238

Peer-reviewed studies (334)

PaperAuthorsJournalYearType
Time-varying mediated effects of the nicotine patch on smoking before and after a quit attempt when it is added to varenicline and counselingKim N et al.Drug and alcohol dependence2026Randomized Controlled Trial
Psilocybin or Nicotine Patch for Smoking Cessation: A Pilot Randomized Clinical TrialJohnson MW et al.JAMA network open2026Randomized Controlled Trial
Effects of Varenicline, Bupropion, Nicotine Patch, and Placebo on Treating Smoking Among Persons With Current or Past Major Depressive Disorder: Secondary Analysis of a Double-Blind, Randomized, Placebo-Controlled TrialKypriotakis G et al.The American journal of psychiatry2025Randomized Controlled Trial
Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depressionAndrews P et al.Journal of affective disorders2024Clinical Trial, Phase II
Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Outcomes in Heavy Drinkers at 26-Week Follow-upRobinson LE et al.Journal of clinical psychopharmacology2024Randomized Controlled Trial
Transdermal Nicotine Treatment and Progression of Early Parkinson's DiseaseOertel WH et al.NEJM evidence2023Randomized Controlled Trial
Adaptive Smoking Cessation Using Precessation Varenicline or Nicotine Patch: A Randomized Clinical TrialDavis JM et al.JAMA network open2023Randomized Controlled Trial
Exenatide as an adjunct to nicotine patch for smoking cessation and prevention of postcessation weight gain among treatment-seeking smokers with pre-diabetes and/or overweight: study protocol for a randomised, placebo-controlled clinical trialYammine L et al.BMJ open2023Clinical Study
Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot studyZhu C et al.Addiction (Abingdon, England)2023Randomized Controlled Trial
The effects of varenicline, bupropion, nicotine patch, and placebo on smoking cessation among smokers with major depression: A randomized clinical trialCinciripini PM et al.Depression and anxiety2022Randomized Controlled Trial
Effect of Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Among Smokers Who Drink Heavily: A Randomized Clinical TrialKing A et al.JAMA network open2022Randomized Controlled Trial
Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment ResponseZakiniaeiz Y et al.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2022Randomized Controlled Trial
Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical TrialBaker TB et al.JAMA2021Randomized Controlled Trial
A Pilot Randomized Trial of Transdermal Nicotine for Pulmonary SarcoidosisCrouser ED et al.Chest2021Randomized Controlled Trial
Estimation of risk of neuropsychiatric adverse events from varenicline, bupropion and nicotine patch versus placebo: secondary analysis of results from the EAGLES trial using Bayes factorsBeard E et al.Addiction (Abingdon, England)2021Randomized Controlled Trial
Exenatide Adjunct to Nicotine Patch Facilitates Smoking Cessation and May Reduce Post-Cessation Weight Gain: A Pilot Randomized Controlled TrialYammine L et al.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2021Randomized Controlled Trial
Targeting mailed nicotine patch distribution interventions to rural regions of Canada: protocol for a randomized controlled trialCunningham JA et al.BMC public health2020Clinical Study
Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trialLandim FS et al.International journal of oral and maxillofacial surgery2020Randomized Controlled Trial
Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trialSchnoll R et al.Drug and alcohol dependence2020Randomized Controlled Trial
Nicotine patch for cannabis withdrawal symptom relief: a randomized controlled trialGilbert DG et al.Psychopharmacology2020Randomized Controlled Trial
Combination Lorcaserin and Nicotine Patch for Smoking Cessation Without Weight GainRose JE et al.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020Randomized Controlled Trial
Nicotine patches used in combination with e-cigarettes (with and without nicotine) for smoking cessation: a pragmatic, randomised trialWalker N et al.The Lancet. Respiratory medicine2020Pragmatic Clinical Trial
The Network Structure of Tobacco Withdrawal in a Community Sample of Smokers Treated With Nicotine Patch and Behavioral CounselingLydon-Staley DM et al.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020Randomized Controlled Trial
Combined nicotine patch with gum versus nicotine patch alone in smoking cessation in Hong Kong primary care clinics: a randomised controlled trialLeung MKW et al.BMC public health2019Randomized Controlled Trial
Randomized Trial of Low-Nicotine Cigarettes and Transdermal NicotineSmith TT et al.American journal of preventive medicine2019Randomized Controlled Trial
Effectiveness of switching to very low nicotine content cigarettes plus nicotine patch versus reducing daily cigarette consumption plus nicotine patch to decrease dependence: an exploratory randomized trialKlemperer EM et al.Addiction (Abingdon, England)2019Randomized Controlled Trial
Neuropsychiatric Safety and Efficacy of Varenicline, Bupropion, and Nicotine Patch in Smokers With Psychotic, Anxiety, and Mood Disorders in the EAGLES TrialEvins AE et al.Journal of clinical psychopharmacology2019Randomized Controlled Trial
A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary CarePiper ME et al.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine2018Randomized Controlled Trial
Transdermal Nicotine for the Treatment of Mood and Cognitive Symptoms in Nonsmokers With Late-Life DepressionGandelman JA et al.The Journal of clinical psychiatry2018Clinical Trial
Evaluation of nicotine patch in pain control of patients undergoing laparoscopic cholecystectomyMartins Filho ED et al.Revista do Colegio Brasileiro de Cirurgioes2018Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Therapeutic nicotine (patch, non-peptide)?

Pure nicotine as a signaling tool, separated from smoking and vaping.

How many registered human trials study Therapeutic nicotine (patch, non-peptide)?

The PeptideWhiz trial index lists 267 registered trials for Therapeutic nicotine (patch, non-peptide), the most recent from 2027.

How much published research exists on Therapeutic nicotine (patch, non-peptide)?

The PeptideWhiz paper index links 334 PubMed papers to Therapeutic nicotine (patch, non-peptide); by study type, 1722 human and 211 animal studies.

Which conditions is Therapeutic nicotine (patch, non-peptide) researched for?

Lung health, asthma & COPD, Rheumatoid arthritis, Lupus (SLE), Heart repair: after heart attack, heart failure & enlarged heart, Atherosclerosis, cardiovascular disease & high blood pressure, Dementia, Alzheimer's & cognitive decline, Autism support, Candida & persistent bacterial infections, Chronic pain: fibromyalgia & CRPS, Hashimoto's (autoimmune thyroid), Lyme disease & chronic infections, Psoriasis and psoriatic arthritis, Carpal tunnel, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, High cholesterol and statins, Osteoarthritis, cartilage loss & avoiding joint replacement, Acid reflux and GERD, Anti-aging & longevity, Anxiety and panic, Cognition, focus & brain performance, Concussion, traumatic brain injury & stroke recovery, Fat loss, obesity & body recomposition, Fight-or-flight and nervous system overdrive, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Neuropathy and CRPS, Parkinson's disease, Post-surgical inflammation and surgery recovery, Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep problems (incl. insomnia on peptides).

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research