What is Terlipressin?

A synthetic vasopressin analog (Terlivaz) used for kidney failure in advanced liver disease and for variceal bleeding.

Terlipressin in the library · · Human Trials · What are peptides?

95 registered trials · 187 indexed papers · 198 human / 0 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A synthetic vasopressin analog (Terlivaz) used for kidney failure in advanced liver disease and for variceal bleeding.

Type: Synthetic vasopressin analog.

Definition (National Library of Medicine)

“An inactive peptide prodrug that is slowly converted in the body to lypressin.”

  • MeSH: Terlipressin

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Terlipressin is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (95)

TrialPhaseStatusYearEnrolled
Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunctionnot yet recruiting202664
Terlipressin vs Placebo to Reduce Bleeding in Fibroid Surgerynot yet recruiting202680
Effect of Terlipressin for Intraoperative Blood Pressure Management in Kidney Transplantationactive not recruiting2025150
Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver Transplantationrecruiting202550
Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal Syndromecompleted202560
Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal BleedPhase 2/Phase 3not yet recruiting202560
Intraoperative Continuous Terlipressin Infusion is Associated With Reduced Severe Postoperative Complications After Laparoscopic Hepatectomy: a Prospective Propensity Score-matched Cohort Studycompleted2024161
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal SyndromePhase 2active not recruiting202454
Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Diseasecompleted2024490
Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shockunknown2024126
Continuous Versus Bolus Infusion of Terlipressin for Portal Hypertension Related Bleeding in Liver Cirrhosisunknown202440
Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation PatientsPhase 4completed2023104
Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal SyndromePhase 2unknown202395
Efficacy of Continuous Terlipressin Therapy After Endoscopic Variceal LigationPhase 3unknown2023165
Methods Decreasing Bleeding in Open MyomectomyPhase 4unknown2023105
ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial.Phase 3completed2022315
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver CirrhoticsPhase 1recruiting202274
HRS-AKI Treatment With TIPS in Patients With Cirrhosisrecruiting2022124
The Effect of Intramyometrial Injection of Terlipressin Versus Intramyometrial Injection of Carbitocin on Hemoglobin and Blood Loss During Laparoscopic Myomectomy Operationsunknown202299
The Effect of Intracapsular Injection of Terlipressin Versus Carbitocin on Hemoglobin and Blood Loss During Laparoscopic Myomectomy Operationsunknown202299
The Effect of Intramyometrial Injection of Terlipressin Versus Carbitocin on Hemoglobin and Blood Loss During Open Myomectomy Operations Using Haemostatic Tourniquets:completed202299
Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplastycompleted2022135
Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic ShockPhase 3unknown2022152
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trialunknown2022100
A Study for Evaluation of BIV201 to Reduce Ascites and Complications in Patients With Cirrhosis and Refractory AscitesPhase 2terminated202115
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapycompleted2021109
The Effect of Intramyometrial Injection of Terlipressin Versus Carbitocin on Hemoglobin and Blood Loss During Open Myomectomy Operations Without Using Haemostatic Tourniquetsrecruiting2021162
Comparison of Bolus Versus Continuous Infusion of Terlipressin Cirrhotic Patients With Septic Shock.unknown2021310
Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic PatientsPhase 1unknown202136
Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)Phase 3completed202050
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.completed202070
Terlipressin for Refractory Septic ShockPhase 2unknown2020130
Hemodynamic Profile of Terlipressin and Octreotide in Patients With Cirrhosis and Portal Hypertension. A Randomised, Single Blinded Clinical Trial.Phase 4unknown202036
Does Terlipressin Improve Renal Outcome After Liver SurgeryPhase 2withdrawn2020
Terlipressin Infusion Alone Vs Terlipressin With Noradrenaline Infusion In The Treatment of Hepatorenal Syndrome Type 1Phase 3completed201960
Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903)Phase 4unknown201960
Effects of Terlipressin on Renal Perfusion in Patients With Septic Shockcompleted201922
The Effect of Terlipressin on Recovery of Liver Function After HepatectomyPhase 3unknown201986
Methylene Blue Versus Vasopressin Analogue for Treatment of Septic Shock in Preterm NeonatePhase 2unknown201936
2- Day vs. 5- Day Terlipressin and Ceftriaxone in the Control Acute Gastroesophageal Variceal HemorrhagePhase 4unknown2019100

Peer-reviewed studies (187)

PaperAuthorsJournalYearType
Influence of Albumin Treatment Duration on Outcome of Terlipressin Therapy in Patients With HRS-AKISchleicher EM et al.Liver international : official journal of the International Association for the Study of the Liver2026Observational Study
Chronic Kidney Disease Does Not Influence Response to Terlipressin in Hepatorenal Syndrome-Acute Kidney InjuryUschner FE et al.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026Observational Study
Clinical Outcomes of Terlipressin Using Continuous Infusion Versus Bolus in Patients With Acute Variceal Hemorrhage-A Randomized Controlled TrialAbid S et al.Journal of clinical gastroenterology2026Randomized Controlled Trial
The relationship between mean arterial pressure and terlipressin in hepatorenal syndrome-acute kidney injury reversal: A post hoc analysisCullaro G et al.Hepatology (Baltimore, Md.)2026Randomized Controlled Trial
Terlipressin for Hepatorenal Syndrome in Patients With Early-Stage Acute-on-Chronic Liver FailureRockey DC et al.Liver international : official journal of the International Association for the Study of the Liver2025Randomized Controlled Trial
Adjunctive terlipressin versus placebo in the treatment of refractory septic shock: a randomized, placebo-controlled trialTongyoo S et al.Critical care (London, England)2025Randomized Controlled Trial
Bradycardia and Other Arrhythmias in Patients With Hepatorenal Syndrome-Acute Kidney Injury Following Terlipressin Treatment: A Pooled Analysis of Three North American Phase III Clinical StudiesBajaj JS et al.Alimentary pharmacology & therapeutics2025Randomized Controlled Trial
Predictors of response to terlipressin therapy in hepatorenal syndrome: Metabolomic and proteomic analysis from the CONFIRM trialAllegretti AS et al.Hepatology communications2025Randomized Controlled Trial
Addition of midodrine to albumin reduces the incidence of complications of large-volume paracentesis: an RCT comparing midodrine, terlipressin, and albuminKulkarni AV et al.Hepatology international2025Randomized Controlled Trial
Targeted albumin infusions in hospitalized patients with cirrhosis receiving terlipressin: A post-hoc analysis of ATTIRETorp N et al.Annals of hepatology2025Randomized Controlled Trial
Safety and efficacy of continuous infusion terlipressin (BIV201): A phase 2 trial in patients with decompensated cirrhosis and refractory ascitesBajaj JS et al.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2025Randomized Controlled Trial
The effect of intramyometrial injection of terlipressin versus carbetocin on hemoglobin and blood loss during open myomectomy operations without using haemostatic tourniquets: Double blinded randomized placebo-controlled trialElbanna W et al.European journal of obstetrics, gynecology, and reproductive biology2025Randomized Controlled Trial
The Impact of Intracervical Terlipressin on Intravasation and Venous Embolization During Transcervical Myomectomy and Endometrium Resection: A Randomized Controlled StudyOverdijk LE et al.Journal of minimally invasive gynecology2025Randomized Controlled Trial
Effect of Continuous Infusion Therapy With Low-dose Terlipressin Combined With Norepinephrine on Hemodynamics, Inflammatory Markers, and Prognosis in Patients With Severe Septic ShockLi W et al.Military medicine2025Randomized Controlled Trial
Early Versus Standard Initiation of Terlipressin for Acute Kidney Injury in ACLF: A Randomized Controlled Trial (eTerli Study)Jindal A et al.Digestive diseases and sciences2024Randomized Controlled Trial
A Noninferiority Trial Comparing 2 Days vs 5 Days of Terlipressin and Ceftriaxone in Terms of 5-Day Rebleeding for Patients With Acute Gastroesophageal Variceal HemorrhageLo GH et al.The American journal of gastroenterology2024Randomized Controlled Trial
Continuous home terlipressin infusion increases handgrip strength and reduces ascites-A prospective randomized crossover studyTerbah R et al.Hepatology (Baltimore, Md.)2024Randomized Controlled Trial
Comparison of 1-day versus 3-day intravenous terlipressin in cirrhosis patients with variceal bleeding: A pilot randomised controlled trialVaishnav M et al.Alimentary pharmacology & therapeutics2024Randomized Controlled Trial
Decreased need for RRT in liver transplant recipients after pretransplant treatment of hepatorenal syndrome-type 1 with terlipressinWeinberg EM et al.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2024Randomized Controlled Trial
Outcomes of patients with hepatorenal syndrome undergoing liver transplantation in the era of terlipressinTerbah R et al.European journal of gastroenterology & hepatology2023Observational Study
Prophylactic terlipressin infusion for severe postreperfusion syndrome in patients undergoing deceased donor liver transplantation: the TIPS-DDLT randomized controlled trialZhang L et al.International journal of surgery (London, England)2023Randomized Controlled Trial
Combination of terlipressin and noradrenaline versus terlipressin in hepatorenal syndrome with early non-response to terlipressin infusion: A randomized trialSingh V et al.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2023Randomized Controlled Trial
Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus SurgeryPavlov VE et al.The Laryngoscope2023Randomized Controlled Trial
Liver-HERO: hepatorenal syndrome-acute kidney injury (HRS-AKI) treatment with transjugular intrahepatic portosystemic shunt in patients with cirrhosis-a randomized controlled trialRipoll C et al.Trials2023Randomized Controlled Trial
Low-dose continuous terlipressin infusion is effective and safer than intravenous bolus injections in reducing portal pressure and control of acute variceal bleedingArora V et al.Hepatology international2023Randomized Controlled Trial
Terlipressin use and respiratory failure in patients with hepatorenal syndrome type 1 and severe acute-on-chronic liver failureWong F et al.Alimentary pharmacology & therapeutics2022Randomized Controlled Trial
Addition of terlipressin to norepinephrine in septic shock and effect of renal perfusion: a pilot studyWang J et al.Renal failure2022Randomized Controlled Trial
RATIONAL FOR CONTINUING TERLIPRESSIN AFTER ENDOSCOPIC VARICEAL LIGATION IN ACUTE VARICEAL HAEMORRHAGE NEEDS FURTHER EVIDENCE: A PILOT STUDYPoudel RC et al.Arquivos de gastroenterologia2022Randomized Controlled Trial
Methylene blue versus vasopressin analog for refractory septic shock in the preterm neonate: A randomized controlled trialIsmail R et al.Journal of neonatal-perinatal medicine2022Randomized Controlled Trial
Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story ForwardBelcher JM et al.American journal of kidney diseases : the official journal of the National Kidney Foundation2022Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Terlipressin?

A synthetic vasopressin analog (Terlivaz) used for kidney failure in advanced liver disease and for variceal bleeding.

How many registered human trials study Terlipressin?

The PeptideWhiz trial index lists 95 registered trials for Terlipressin, the most recent from 2026.

How much published research exists on Terlipressin?

The PeptideWhiz paper index links 187 PubMed papers to Terlipressin; by study type, 198 human and 0 animal studies.

Which conditions is Terlipressin researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Fatty liver & elevated liver enzymes, Immune system (general), Kidney protection (CKD, diabetic kidney, lupus kidney), Low blood pressure and orthostatic hypotension, Lung health, asthma & COPD, Parkinson's disease, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Skin, hair loss, wounds & mast-cell/histamine reactivity, Varicose veins.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research