What is VIP (Vasoactive Intestinal Peptide)?

A 28-amino-acid neuropeptide that relaxes smooth muscle and calms immune activity; aviptadil is a synthetic form.

VIP (Vasoactive Intestinal Peptide) in the library · · Human Trials · What are peptides?

15 registered trials · 145 indexed papers · 2510 human / 8703 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 28-amino-acid neuropeptide that relaxes smooth muscle and calms immune activity; aviptadil is a synthetic form.

Type: Neuropeptide.

Definition (National Library of Medicine)

“A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (receptors, vasoactive intestinal peptide).”

  • MeSH: Vasoactive Intestinal Peptide

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when VIP (Vasoactive Intestinal Peptide) is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (15)

TrialPhaseStatusYearEnrolled
Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19Phase 3withdrawn2021
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19Phase 3completed2021473
Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)Phase 3completed2021471
Inhaled Aviptadil for the Treatment of COVID-19 in Patients at High Risk for ARDSPhase 2terminated202183
A Clinical Study Evaluating Inhaled Aviptadil on COVID-19Phase 2completed202180
Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19Phase 2/Phase 3terminated2021144
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill PatientsPhase 2active not recruiting20201500
Intravenous Aviptadil for Critical COVID-19 With Respiratory FailurePhase 2/Phase 3completed2020203
ZYESAMI (Aviptadil) Intermediate Population Expanded Access Protocol (SAMICARE)no longer available2020
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patientscompleted202021
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) on Headache, Cranial Hemodynamic and Autonomic Symptoms in Healthy Volunteerscompleted201912
Effect of PACAP38/VIP on Migraineurs Measured by Magnetic Resonancecompleted201124
Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide in Migraineurscompleted200412
Vasoactive Intestinal Peptide in COPDcompleted200334
Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and SepsisPhase 1completed199818

Peer-reviewed studies (145)

PaperAuthorsJournalYearType
Clearance of multiple antibiotic-resistant coagulase-negative staphylococci is selectively associated with higher circulating α-melanocyte stimulating hormone in patients evaluated for chronic inflammatory response syndromeDiTulio M et al.Frontiers in endocrinology2026Observational Study
The mechanism of transcutaneous gastric pacing treatment on gastrointestinal motility recovery and inflammation improvement in early-stage acute pancreatitis patientsJia Z et al.BMC gastroenterology2024Randomized Controlled Trial
[Clinical efficacy of intranasal acupuncture combined with Tiaoshen acupuncture in the treatment of moderate-to-severe persistent allergic rhinitis]Dong BY et al.Zhen ci yan jiu = Acupuncture research2024Randomized Controlled Trial
Hemostatic mechanism of Jianpi Yiqi Shexue decoction in treatment of immune thrombocytopeniaRuibai LI et al.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024Randomized Controlled Trial
Transcutaneous Electrical Acustimulation Improves Constipation Symptoms and Accelerates Colonic Transit in Patients With Slow Transit Constipation Through Autonomic MechanismYang J et al.Neuromodulation : journal of the International Neuromodulation Society2024Randomized Controlled Trial
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trialBrown SM et al.The Lancet. Respiratory medicine2023Randomized Controlled Trial
The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled studyRasmussen NB et al.The journal of headache and pain2023Randomized Controlled Trial
Role of tear vasoactive intestinal peptide on dry eyes after laser keratorefractive surgeryKang Y et al.BMC ophthalmology2023Clinical Trial
Association of Apremilast With Vascular Inflammation and Cardiometabolic Function in Patients With Psoriasis: The VIP-A Phase 4, Open-label, Nonrandomized Clinical TrialGelfand JM et al.JAMA dermatology2022Clinical Trial, Phase IV
Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trialBoesing M et al.Trials2022Clinical Study
The Use of IV Vasoactive Intestinal Peptide (Aviptadil) in Patients With Critical COVID-19 Respiratory Failure: Results of a 60-Day Randomized Controlled TrialYoussef JG et al.Critical care medicine2022Randomized Controlled Trial
PACAP38- and VIP-induced cluster headache attacks are not associated with changes of plasma CGRP or markers of mast cell activationPellesi L et al.Cephalalgia : an international journal of headache2022Randomized Controlled Trial
Effect of Vasoactive Intestinal Polypeptide on Development of Migraine Headaches: A Randomized Clinical TrialPellesi L et al.JAMA network open2021Randomized Controlled Trial
Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy femalesSimon RA et al.Scientific reports2021Clinical Trial
The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headacheVollesen ALH et al.Cephalalgia : an international journal of headache2020Randomized Controlled Trial
Serum CGRP, VIP, and PACAP usefulness in migraine: a case-control study in chronic migraine patients in real clinical practicePérez-Pereda S et al.Molecular biology reports2020Clinical Trial
Two-hour infusion of vasoactive intestinal polypeptide induces delayed headache and extracranial vasodilation in healthy volunteersPellesi L et al.Cephalalgia : an international journal of headache2020Randomized Controlled Trial
A Randomized Placebo-Controlled Trial of Secukinumab on Aortic Vascular Inflammation in Moderate-to-Severe Plaque Psoriasis (VIP-S)Gelfand JM et al.The Journal of investigative dermatology2020Randomized Controlled Trial
A Phase IV, Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effects of Ustekinumab on Vascular Inflammation in Psoriasis (the VIP-U Trial)Gelfand JM et al.The Journal of investigative dermatology2020Randomized Controlled Trial
[SERUM CONTENTS OF SUBSTANCE P, ENDOTHELIN-1 AND VASOACTIVE INTESTINAL PEPTIDE IN CHILDREN WITH RECURRENT BRONCHITIS AND VERTEBROBASILAR INSUFFICIENCY]Slutskaya T et al.Georgian medical news2019Observational Study
Calcitonin-gene related peptide and disease activity in cluster headacheSnoer A et al.Cephalalgia : an international journal of headache2019Randomized Controlled Trial
Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical studyÖzdemir MB et al.Clinical oral investigations2019Randomized Controlled Trial
Why are Behçet's disease patients always exhausted?Senusi AA et al.Clinical and experimental rheumatology2018Observational Study
A correlation between gastrointestinal dysfunction and cirrhosis severityWang P et al.Medicine2018Observational Study
[Effects of highly selective branches neurotomy of vidian nerve with low temperature plasma on vasoactive intestinal peptide in nasal mucosal cells of patients with allergic rhinitis]He P et al.Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery2018Clinical Trial
[Acupuncture with smoothing liver and regulating qi for post-stroke slow transit constipation and its gastrointestinal hormone level]Gao Y et al.Zhongguo zhen jiu = Chinese acupuncture & moxibustion2017Randomized Controlled Trial
Effect of XiangBin granules on post-operative gastrointestinal function and brain-gut peptides after transabdominal gynecological surgeryWen SL et al.European journal of obstetrics, gynecology, and reproductive biology2016Randomized Controlled Trial
Modulation of circulating vasoactive peptides and extracellular matrix proteins are two novel mechanisms in the cardioprotective action of acarboseRudovich N et al.Minerva endocrinologica2016Randomized Controlled Trial
Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndromeZhenzhong L et al.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan2015Randomized Controlled Trial
Clinical study of electro-acupuncture treatment with different intensities for functional constipation patientsXiong F et al.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban2014Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is VIP (Vasoactive Intestinal Peptide)?

A 28-amino-acid neuropeptide that relaxes smooth muscle and calms immune activity; aviptadil is a synthetic form.

How many registered human trials study VIP (Vasoactive Intestinal Peptide)?

The PeptideWhiz trial index lists 15 registered trials for VIP (Vasoactive Intestinal Peptide), the most recent from 2021.

How much published research exists on VIP (Vasoactive Intestinal Peptide)?

The PeptideWhiz paper index links 145 PubMed papers to VIP (Vasoactive Intestinal Peptide); by study type, 2510 human and 8703 animal studies.

Which conditions is VIP (Vasoactive Intestinal Peptide) researched for?

Anxiety and panic, Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Concussion, traumatic brain injury & stroke recovery, Delayed gastric emptying on GLP-1 medicines, Dementia, Alzheimer's & cognitive decline, Eczema, Gallbladder and gallstones, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, Immune system (general), Low blood pressure and orthostatic hypotension, Lung health, asthma & COPD, Migraine, Neuropathy and CRPS, Pancreatitis (after the acute phase), Post-surgical inflammation and surgery recovery, Psoriasis and psoriatic arthritis, Rosacea, Seasonal allergies, Sexual function & libido (women and men), Skin, hair loss, wounds & mast-cell/histamine reactivity.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research