What is Thymopentin?

A five-amino-acid fragment of the thymic hormone thymopoietin (Arg-Lys-Asp-Val-Tyr), studied as an immunomodulator in the 1980s and 1990s.

Thymopentin in the library · · Human Trials · What are peptides?

9 registered trials · 92 indexed papers · 1 human / 11 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Thymopentin is described as the active pentapeptide of thymopoietin. It has been used in some countries for immune deficiency and was trialed in rheumatoid arthritis and atopic dermatitis.

Mechanism (as described)

It is described as promoting T-cell differentiation and balancing immune responses (Singh et al., 1998).

Evidence (as described)

A controlled trial reported reduced severity of atopic dermatitis (Leung et al., 1990); rheumatoid arthritis results were mixed (Sundal et al., 1994).

Status

Approved historically in some countries (e.g., Italy, China); not in the US.

Registered human trials (9)

Trial	Phase	Status	Year	Enrolled
The Prospective Clinical Study of Precision PRaG Therapy in Elderly Patients With Advanced Solid Malignant Tumors (PRaG9.0)	Phase 2	not yet recruiting	2023	29
Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma	Phase 3	unknown	2007	220
Double Blind Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients		completed	2001
A Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients		completed	2001
Double Blind Study of Thymopentin Effects on Patients With HIV-1 Infection		completed	2001
Double Blind Study of Thymopentin Effects on Patients With HIV-1 Infection		completed	2001
Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT or ddI) or Combination (AZT / ddI or AZT / ddC) Anti-Retroviral Therapy	Phase 3	completed	2001
The Effects of Thymopentin on HIV Infectivity of Blood Cells and Semen in HIV-Infected Patients		completed	2001
A Study of Timunox (Thymopentin) in HIV-Infected Patients Receiving Other Anti-HIV Drugs	Phase 2	completed	2001	60

Peer-reviewed studies (92)

Paper	Authors	Journal	Year	Type
The effect of thymopentin add-on in hepatitis B e antigen positive chronic hepatitis B after virus suppression by peginterferon plus entecavir therapy	Ma Y et al.	Cellular and molecular biology (Noisy-le-Grand, France)	2019	Randomized Controlled Trial
Thymopentin improves cardiac function in older patients with chronic heart failure	Xiaojing C et al.	Anatolian journal of cardiology	2017	Randomized Controlled Trial
Subcutaneous injection of thymopentin in the area of the supramammary lymph node to reduce milk somatic cell count in subclinically mastitic cows	Guan R et al.	Journal of veterinary pharmacology and therapeutics	2016	Randomized Controlled Trial
[Thymopentin 5 in treatment of relapse after extended thymectomy: a randomized comparative clinical trial of 135 patients with myasthenia gravis]	Liu WB et al.	Zhonghua yi xue za zhi	2008	Randomized Controlled Trial
[Study on the efficacy and safety of high dose thymopentin combined with trans-artery chemoembolization for primary liver cancer]	Li T et al.	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2007	Randomized Controlled Trial
[Controlled clinical study on 49 patients of SARS treated by integrative Chinese and Western medicine]	Zhang RL et al.	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine	2003	Controlled Clinical Trial
[Clinical trial to verify the value of the CD14(+) monocyte human leukocyte antigen DR as a marker in evaluating immunosuppression in patients with severe sepsis]	Lin HY et al.	Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue	2003	Clinical Trial
[Therapeutic effects of Lamivudine in combination with Thymopentin on chronic hepatitis B]	Tang S et al.	Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology	2002	Randomized Controlled Trial
[Modulating effects of thymopentin on the immune system of severely burned patients]	Xin G et al.	Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns	2001	Randomized Controlled Trial
Successful interferon alpha therapy in atopic dermatitis of Besnier's prurigo pattern with normal serum IgE and blood eosinophil fraction: randomized case-controlled study	Noh G et al.	Cytokine	2001	Randomized Controlled Trial
Chemo-immunotherapy in advanced head and neck cancer	Recchia F et al.	Anticancer research	1999	Clinical Trial, Phase II
Evaluation of clinical efficacy and tolerability of intravenous high dose thymopentin in advanced melanoma patients	Cascinelli N et al.	Melanoma research	1998	Clinical Trial
[Recurrent urinary tract infections. Biological suppositions and clinical treatment with thymopentin]	Fontana G et al.	Minerva urologica e nefrologica = The Italian journal of urology and nephrology	1997	Clinical Trial
Phase I-II study of dose intensified chemotherapy with filgrastim and thymopentin in patients with advanced cancer	Recchia F et al.	La Clinica terapeutica	1997	Randomized Controlled Trial
Topical thymopentin therapy in HIV positive patients with recurrent oral candidiasis: a pilot study	Coppola S et al.	The new microbiologica	1996	Clinical Trial
The prognostic significance of serum viral load, codon 215 reverse transcriptase mutation and CD4+ T cells on progression of HIV disease in a double-blind study of thymopentin	Merigan TC et al.	AIDS (London, England)	1996	Randomized Controlled Trial
An imbalance in T-helper cell subsets alters immune response after cardiac surgery	Markewitz A et al.	European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery	1996	Randomized Controlled Trial
Biological activity and clinical efficacy of intravenous high-dose thymopentin in metastatic melanoma patients	Clemente C et al.	Melanoma research	1996	Clinical Trial, Phase II
Sequential biochemotherapy for metastatic colorectal cancer using fluorouracil, folinic acid, thymopentin and interleukin-2: clinical and immunological effects	Lopez M et al.	Annals of oncology : official journal of the European Society for Medical Oncology	1995	Clinical Trial, Phase II
Safety and efficacy of thymopentin in zidovudine (AZT)-treated asymptomatic HIV-infected subjects with 200-500 CD4 cells/mm3: a double-blind placebo-controlled trial	Goldstein G et al.	Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association	1995	Randomized Controlled Trial
Sequential subcutaneous thymopentin, interferon alpha-2a and interleukin-2 in metastatic renal cell cancer	Di Lauro L et al.	Tumori	1995	Clinical Trial
Humoral response to influenza hemagglutinin: oligoclonal spectrotype and failure of thymopentin as immunoadjuvant	Biselli R et al.	Gerontology	1995	Controlled Clinical Trial
[Role of thymopentin in the prevention of post-splenectomy infections]	Vecchio R et al.	Il Giornale di chirurgia	1995	Controlled Clinical Trial
[Evaluation of the treatment with thymopentin associated with radiotherapy in head and neck tumors]	Trinci M et al.	La Clinica terapeutica	1995	Clinical Trial
A double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of thymopentin as an adjunctive treatment in atopic dermatitis	Stiller MJ et al.	Journal of the American Academy of Dermatology	1994	Randomized Controlled Trial
Impact of thymopentin on the incidence and severity of postoperative infection: a randomized controlled trial	Braga M et al.	The British journal of surgery	1994	Randomized Controlled Trial
[Prevention of immunodeficiency and postoperative infective complications in patients undergoing surgical resection for carcinoma of the colon-rectum. Clinical study on 50 cases, using thymus hormones and thymopentin in particular]	Elia P et al.	Minerva chirurgica	1994	Controlled Clinical Trial
A randomized controlled trial of thymopentin therapy in patients with chronic hepatitis B	Fattovich G et al.	Journal of hepatology	1994	Randomized Controlled Trial
Thymopentin treatment of rheumatoid arthritis	Sundal E et al.	Arzneimittel-Forschung	1994	Randomized Controlled Trial
[Changes in immune status due to anesthesia and surgical intervention. The role of thymopentin and interleukins]	Launo C et al.	Minerva anestesiologica	1994	Randomized Controlled Trial

More cited research

Thymosin-like peptides as potential immunostimulants. Synthesis via the polymeric-reagent method (1990, human observational)
Yeast Expressed Hybrid Peptide CLP Abridged Pro-Inflammatory Cytokine Levels by Endotoxin Neutralization (2023, animal)
A Novel Peptide Ameliorates LPS-Induced Intestinal Inflammation and Mucosal Barrier Damage via Its Antioxidant and Antiendotoxin Effects (2019, animal)
Design and Development of a Novel Peptide for Treating Intestinal Inflammation (2019, animal)
Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells (2008, animal)

Conditions researched

Related compounds

FAQ

What is Thymopentin?

A five-amino-acid fragment of the thymic hormone thymopoietin (Arg-Lys-Asp-Val-Tyr), studied as an immunomodulator in the 1980s and 1990s.

How many registered human trials study Thymopentin?

The PeptideWhiz trial index lists 9 registered trials for Thymopentin, the most recent from 2023.

How much published research exists on Thymopentin?

The PeptideWhiz paper index links 92 PubMed papers to Thymopentin; by study type, 1 human and 11 animal studies.

Which conditions is Thymopentin researched for?

Candida & persistent bacterial infections, Eczema, Heart repair: after heart attack, heart failure & enlarged heart, Herpes (HSV) and cold sores, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Post-surgical inflammation and surgery recovery, Recurring UTIs, Rheumatoid arthritis, Seasonal allergies, Skin, hair loss, wounds & mast-cell/histamine reactivity.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research