What is Substance P?
An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.
Substance P in the library · · Human Trials · What are peptides?
12 registered trials · 296 indexed papers · 886 human / 1936 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.
Type: Neuropeptide.
Definition (National Library of Medicine)
“An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of pain, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.”
- MeSH: Substance P
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Substance P is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (12)
Peer-reviewed studies (296)
More cited research
- Changes in TRPV1 Expression as Well as Substance P and Vasoactive Intestinal Peptide Levels Are Associated with Recurrence of Pterygium (2022, human observational)
- Changes in ghrelin, substance P and vasoactive intestinal peptide levels in the gastroduodenal mucosa of patients with morbid obesity (2021, human observational)
- Serum substance P and vasoactive intestinal peptide levels in infants with acute intussusception (2019, human observational)
- Neuroimmune cross-talk in Helicobacter pylori infection: analysis of substance P and vasoactive intestinal peptide expression in gastric enteric nervous system (2018, human observational)
- Aspirin Administration Affects Neurochemical Characterization of Substance P-Like Immunoreactive (SP-LI) Nodose Ganglia Neurons Supplying the Porcine Stomach (2020, animal)
- Chemotactic activities of vasoactive intestinal peptide, neuropeptide Y and substance P in Leishmania braziliensis (2020, animal)
- Rfamide-related peptide-3 suppresses the substance P-induced promotion of the reproductive performance in female rats modulating hypothalamic Kisspeptin express (2020, animal)
- Blocking CXCR1/2 contributes to amelioration of lipopolysaccharide-induced sepsis by downregulating substance P (2019, animal)
Conditions researched
- Migraine
- Acid reflux and GERD
- Anti-aging & longevity
- Anxiety and panic
- Atherosclerosis, cardiovascular disease & high blood pressure
- Chronic and systemic inflammation
- Chronic pain: fibromyalgia & CRPS
- Concussion, traumatic brain injury & stroke recovery
- EBV and reactivated viruses
- Eczema
- Fat loss, obesity & body recomposition
- Fight-or-flight and nervous system overdrive
- Gallbladder and gallstones
- Gum disease (periodontal) & oral health
- Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers
- Heart repair: after heart attack, heart failure & enlarged heart
- Immune system (general)
- Insulin resistance, prediabetes & type 2 diabetes
- Lung health, asthma & COPD
- Menstrual cramps (dysmenorrhea)
- Osteoarthritis, cartilage loss & avoiding joint replacement
- Post-surgical inflammation and surgery recovery
- Pregnancy and breastfeeding: safety notes
- Psoriasis and psoriatic arthritis
- Recurring UTIs
- Rheumatoid arthritis
- Rosacea
- Seasonal allergies
- Sexual function & libido (women and men)
- Skin, hair loss, wounds & mast-cell/histamine reactivity
- Sleep problems (incl. insomnia on peptides)
- Tendon, ligament, muscle & joint injuries (incl. athletes)
- Trigeminal neuralgia
Related compounds
- ACTH (Corticotropin)
- Glutathione
- Parathyroid Hormone (PTH 1-84)
- BPC-157
- Cyanocobalamin (Vitamin B12)
- Calcitonin
- CGRP (Calcitonin Gene-Related Peptide)
- Oxytocin
- Endothelin-1
- Insulin (regular human)
FAQ
What is Substance P?
An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.
How many registered human trials study Substance P?
The PeptideWhiz trial index lists 12 registered trials for Substance P, the most recent from 2025.
How much published research exists on Substance P?
The PeptideWhiz paper index links 296 PubMed papers to Substance P; by study type, 886 human and 1936 animal studies.
Which conditions is Substance P researched for?
Migraine, Acid reflux and GERD, Anti-aging & longevity, Anxiety and panic, Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Chronic pain: fibromyalgia & CRPS, Concussion, traumatic brain injury & stroke recovery, EBV and reactivated viruses, Eczema, Fat loss, obesity & body recomposition, Fight-or-flight and nervous system overdrive, Gallbladder and gallstones, Gum disease (periodontal) & oral health, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Heart repair: after heart attack, heart failure & enlarged heart, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Lung health, asthma & COPD, Menstrual cramps (dysmenorrhea), Osteoarthritis, cartilage loss & avoiding joint replacement, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Psoriasis and psoriatic arthritis, Recurring UTIs, Rheumatoid arthritis, Rosacea, Seasonal allergies, Sexual function & libido (women and men), Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep problems (incl. insomnia on peptides), Tendon, ligament, muscle & joint injuries (incl. athletes), Trigeminal neuralgia.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).