Home › Peptides A to Z › CosyntropinWhat is Cosyntropin? A synthetic 24-amino-acid fragment of ACTH (also tetracosactide, Synacthen) used mainly in the adrenal stimulation test.
Cosyntropin in the library · · Human Trials · What are peptides?
39 registered trials · 163 indexed papers · 244 human / 27 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is A synthetic 24-amino-acid fragment of ACTH (also tetracosactide, Synacthen) used mainly in the adrenal stimulation test.
Type: Synthetic peptide (ACTH fragment).
Definition (National Library of Medicine) “A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.”
Human research The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Cosyntropin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (39) Peer-reviewed studies (163) Paper Authors Journal Year Type Low-dose, not low-risk: potential adrenal suppression identified by a risk-based approach to ACTH testing Asano R et al. Clinical rheumatology 2026 Observational Study Determining the comparative pharmacodynamic equivalence of a non-invasive diagnostic test for patients with adrenal insufficiency using a randomised 2-way crossover trial: the STARLIT-3 study protocol Date K et al. BMJ open 2026 Clinical Study Overnight Dexamethasone in Primary Aldosteronism Screening in Patients on Interfering Therapy (ODEPRASC): A Diagnostic Interpretability Study Protocol Kmieć P et al. Journal of clinical hypertension (Greenwich, Conn.) 2025 Clinical Study No effect of tetracosactide for treatment of postdural puncture headaches in parturient women: a double-blind randomised controlled clinical trial Dziadzko M et al. British journal of anaesthesia 2025 Randomized Controlled Trial Subcutaneous route is a reliable alternative for ACTH-stimulated steroid profiling Dhananjaya MS et al. Endocrine 2025 Randomized Controlled Trial Randomised, placebo-controlled, double-blinded, four-way crossover trial to demonstrate the comparative pharmacodynamic equivalence of a non-invasive diagnostic test for adrenal insufficiency in a healthy population: the STARLIT-2 study protocol Date KL et al. BMJ open 2024 Clinical Study Hypothalamic-Pituitary-Adrenal Axis Response in Patients With Acne Vulgaris Treated With Clascoterone Bhatia N et al. Journal of drugs in dermatology : JDD 2024 Clinical Trial, Phase II Differences in thyroid function tests after administration of a single supraphysiological dose of ACTH or a high dose of a synthetic steroid Markantes GK et al. Steroids 2022 Randomized Controlled Trial Comparison of Cosyntropin, Vigabatrin, and Combination Therapy in New-Onset Infantile Spasms in a Prospective Randomized Trial Knupp KG et al. Journal of child neurology 2022 Randomized Controlled Trial Pharmacokinetics and Pharmacodynamics of Repository Corticotropin Injection Compared With Synthetic ACTH(1-24) Depot and Methylprednisolone in Healthy Subjects Poola N et al. Clinical pharmacology in drug development 2022 Randomized Controlled Trial ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping Tezuka Y et al. The Journal of clinical endocrinology and metabolism 2021 Clinical Trial Comparison of Steroidogenic Exposure Following the Administration of Repository Corticotropin Injection With a Synthetic ACTH(1-24) Depot and Methylprednisolone in Healthy Subjects Wang X et al. Clinical pharmacology in drug development 2021 Randomized Controlled Trial Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test Elder CJ et al. The Journal of clinical endocrinology and metabolism 2020 Randomized Controlled Trial Residual Corticosteroid Production in Autoimmune Addison Disease Sævik ÅB et al. The Journal of clinical endocrinology and metabolism 2020 Clinical Trial ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure Leung JH et al. The Journal of clinical endocrinology and metabolism 2020 Randomized Controlled Trial Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome Kobayashi H et al. European journal of endocrinology 2020 Observational Study Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): a study protocol for a randomised controlled trial Depaulis C et al. Trials 2020 Clinical Study Possible adrenal insufficiency among fatigue patients in a psychosomatic medical clinic Matsubayashi S et al. Endocrine journal 2020 Observational Study Long acting porcine sequence ACTH in the diagnosis of adrenal insufficiency Nair A et al. European journal of endocrinology 2019 Clinical Trial Glucocorticoid induced adrenal insufficiency is common in steroid treated glomerular diseases - proposed strategy for screening and management Karangizi AHK et al. BMC nephrology 2019 Observational Study Cosyntropin testing does not predict response to glucocorticoids in community-acquired pneumonia in a randomized controlled trial Blum CA et al. Clinical endocrinology 2019 Randomized Controlled Trial Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial O'Callaghan FJK et al. The Lancet. Child & adolescent health 2018 Randomized Controlled Trial Clinical characteristics and prevalence of adrenal insufficiency in hemodynamically stable patients with cirrhosis Park SH et al. Medicine 2018 Observational Study The Short Synacthen (Corticotropin) Test Can Be Used to Predict Recovery of Hypothalamo-Pituitary-Adrenal Axis Function Pofi R et al. The Journal of clinical endocrinology and metabolism 2018 Observational Study Is Inappropriate Response to Cosyntropin Stimulation Test an Indication of Corticosteroid Resistance in Septic Shock? Hyvernat H et al. Shock (Augusta, Ga.) 2018 Randomized Controlled Trial Can the gold standard be beaten? How reliable are various modifications of the Synacthen test compared to the insulin tolerance test Kosak M et al. Physiological research 2017 Observational Study Total and free cortisol levels during [amount hidden], and [amount hidden] cosyntropin stimulation tests compared to insulin tolerance test: results of a randomized, prospective, pilot study Peechakara S et al. Endocrine 2017 Randomized Controlled Trial DIAGNOSTIC ACCURACY OF BASAL CORTISOL LEVEL TO PREDICT ADRENAL INSUFFICIENCY IN COSYNTROPIN TESTING: RESULTS FROM AN OBSERVATIONAL COHORT STUDY WITH 804 PATIENTS Struja T et al. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2017 Observational Study Total and free cortisol responses and their relation to outcomes after cardiopulmonary bypass in infants Wald EL et al. The Journal of thoracic and cardiovascular surgery 2017 Observational Study Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial O'Callaghan FJ et al. The Lancet. Neurology 2017 Randomized Controlled Trial
More cited research A comparative study of high-dose and low-dose ACTH therapy for West syndrome (None, human RCT)A comparison between short synacthen test and depot synacthen test in the evaluation of cortisol reserve of adrenal gland in normal subjects (None, human trial (non-randomized))A comparison between the effects of low dose (1 microg) and standard dose (250 microg) ACTH stimulation tests on adrenal P450c17alpha enzyme activity in women w (None, human trial (non-randomized))A comparison of non-tapering vs. tapering prednisolone in acute exacerbation of asthma involving use of the low-dose ACTH test (None, human RCT)Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats (2021, animal)Serotonin release in the rat brain cortex is inhibited by neuropeptide Y but not affected by ACTH1-24, angiotensin II, bradykinin and delta-sleep-inducing pepti (1991, animal)ACTH and adrenal aerobic glycolysis. I: Effects of O-nitrophenylsulphenyl and other ACTH analogues, vasoactive intestinal peptide and human parathyroid hormone( (1987, animal)Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats (1987, animal)Conditions researched Related compounds FAQ What is Cosyntropin? A synthetic 24-amino-acid fragment of ACTH (also tetracosactide, Synacthen) used mainly in the adrenal stimulation test.
How many registered human trials study Cosyntropin? The PeptideWhiz trial index lists 39 registered trials for Cosyntropin, the most recent from 2024.
How much published research exists on Cosyntropin? The PeptideWhiz paper index links 163 PubMed papers to Cosyntropin; by study type, 244 human and 27 animal studies.
Which conditions is Cosyntropin researched for? Acne, Anemia, Atherosclerosis, cardiovascular disease & high blood pressure, Concussion, traumatic brain injury & stroke recovery, EBV and reactivated viruses, Eczema, Fat loss, obesity & body recomposition, Fatigue & low energy (incl. midlife), Hashimoto's (autoimmune thyroid), Heart repair: after heart attack, heart failure & enlarged heart, High cholesterol and statins, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Lung health, asthma & COPD, Migraine, Multiple sclerosis, Muscle disease (myopathy), Osteoporosis and bone density, PCOS, Post-surgical inflammation and surgery recovery, POTS and dysautonomia, Psoriasis and psoriatic arthritis, Rheumatoid arthritis, Seasonal allergies, Sleep problems (incl. insomnia on peptides).
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).