What is Methylene blue (non-peptide stack partner)?

Described as an electron cycler, not just a dye.

Methylene blue (non-peptide stack partner) in the library · · Human Trials · What are peptides?

135 registered trials · 458 indexed papers · 6425 human / 5458 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Described as an electron cycler, not just a dye.

Registered human trials (135)

TrialPhaseStatusYearEnrolled
A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast AbscessesPhase 2not yet recruiting202750
Assessing the Feasibility of Using Methylene Blue in Identifying Ureters During Colorectal SurgeryPhase 4not yet recruiting202620
Randomised Controlled Trial of Fluorescent Urography Using Intravenous Methylene Blue Compared to White Light Alone in Left-sided Colorectal SurgeryPhase 4not yet recruiting2026108
Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound InfectionEARLY_Phase 1not yet recruiting202650
Methylene Blue in Total Knee Arthroplasty (TKA)Phase 1recruiting202620
Early Methylene Blue in the Microhemodynamics of Septic PatientsPhase 2/Phase 3recruiting202650
Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitusrecruiting202632
Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue AbscessesPhase 2not yet recruiting2026120
Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal CancerPhase 2recruiting202526
Laser Treatment With Methylene Blue vs. Nanoparticle-Assisted Photodynamic Therapy for Gingival Pigmentation: A Randomized Clinical Trialcompleted202545
Methylene Blue Treatment of Chronic Hepatitis B Virus InfectionPhase 2recruiting202510
Exploring Different Dose-frequency Home Photodynamic Therapy Protocols Using a Novel Home-targeted LED Device for Onychomycosisactive not recruiting202550
Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesiacompleted2025220
Adjunctive Methylene Blue in Septic ShockPhase 3completed202550
Local Injection Methylene Blue Combined With Radiation in HNSCC PatientsEARLY_Phase 1active not recruiting202510
Investigation of Effect of Formulated Methylene Blue on Treatment of Squamous Cell Carcinoma Skin Cancer in Inoperable Patients and Not Suitable for RadiotherapyPhase 3enrolling by invitation202520
Treatment of Basal Cell Carcinoma (BCC) of the Skin, of the Morpheiform, Infiltrative, and Noduloulcerative Types in Inoperable Patients and Not Suitable for Radiotherapy Using Formulated Methylene BluePhase 3enrolling by invitation202520
Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I StudyPhase 1recruiting202518
Efficacy of Methylene Blue Plus Ropivacaine for Post-Hemorrhoidectomy Pain.Phase 4not yet recruiting2025177
Comparison of Two-Position and Four-Position Cervical Injection Techniques for Sentinel Lymph Node Mapping in Endometrial Cancer Using Methylene Bluerecruiting2025100
Evaluation of Perioperative Cystoscopy and Methylene Blue Test in Detecting Complications in TVT and TOT Proceduresrecruiting202558
Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IVcompleted202420
Methylene Blue for the Treatment of Septic ShockPhase 3completed202488
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shockunknown2024488
Evaluation of Chlorhexidine Gel Associated with Photodynamic Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabeticscompleted202420
The Effect of Methylene Blue Infiltrating Injection on Anal Pain After Milligan-Morgan Surgery: A Randomized Controlled Clinical StudyPhase 3enrolling by invitation202460
A Study of Ropivacaine Combined With Different Concentrations of Methylene Blue Fascia Iliaca Block in Postoperative Analgesia, Cognition, and Hip Function Recovery in Patients Undergoing Hip Arthroplastyunknown202475
Intravenous Methylene Blue for Treating Refractory Neonatal Septic ShockPhase 2/Phase 3not yet recruiting2024130
Perineural Methylene Blue Infusion in Lower Limb Amputation Surgeryrecruiting202372
Effect of Methylene Blue Bladder Instillation on Urinary Tract Injuries During Cesarean Hysterectomy for Placenta Accreta Spectrumcompleted202360
Comparison Between Two Techniques During Thyroidectomy (Conventional Dissection Technique and Injection of Methylene Blue Dye Into Inferior Thyroid Artery Technique) Regarding Recurrent Laryngeal Nerve Identification and PreservationPhase 2/Phase 3completed202340
Methylene Blue Mouthwash for the Treatment of Oral Mucositis Pain in Patients With CancerPhase 3completed202349
A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplastycompleted202390
Low Dose Versus High Dose Methylene Blue in Septic PatientsPhase 2/Phase 3completed202390
A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy.completed2023101
Sentinel Lymph Node Biopsy in Stage AI-IIA Germ Cell Tumorsunknown202344
The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot UlcerEARLY_Phase 1unknown202320
Red Light Photobiomodulation and Topical DisinfectantsPhase 1/Phase 2completed202328
Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asianscompleted202215
Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomycompleted2022136

Peer-reviewed studies (458)

PaperAuthorsJournalYearType
The effect of photodynamic therapy on post-endodontic pain in treatments performed by undergraduate studentsÖvsay E et al.BMC oral health2026Observational Study
Antimicrobial photodynamic therapy improves wound quality and tissue repair in diabetic foot ulcers: A randomized double blind controlled clinical trialChagas PF et al.Journal of photochemistry and photobiology. B, Biology2026Randomized Controlled Trial
Comparison of compound methylene blue (methylene blue + ropivacaine) and bupivacaine liposome for pain control after mixed hemorrhoid surgery: A comprehensive analysis based on clinical studiesMai G et al.The Journal of international medical research2026Observational Study
Efficacy of mechanical debridement with adjunct antimicrobial photodynamic therapy for the management of plaque-induced gingivitis in patients undergoing clear aligner therapy and fixed orthodontic therapyAl-Shammery DPhotodiagnosis and photodynamic therapy2026Randomized Controlled Trial
Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE studyPontes CDN et al.Critical care science2026Clinical Study
Clinical feasibility of chairside methylene blue-mediated photodynamic therapy for oral candidiasisZhou P et al.BMC oral health2026Randomized Controlled Trial
Comparison of antimicrobial photodynamic therapy protocols as adjunct treatment in the management of initial pericoronitis: a randomized, controlled, double-blind clinical trialSchalch TO et al.Clinical oral investigations2026Randomized Controlled Trial
Comparison of methylene blue dye-based chromoendoscopy and Fujifilm virtual chromoendoscopy (blue light imaging and linked color imaging) for dysplasia detection in inflammatory bowel disease: a prospective single-center randomized studyAlshatti Y et al.BMC gastroenterology2026Randomized Controlled Trial
Methylene Blue Mouthwash for Oral Mucositis Pain in Cancer: An Open-Label, Non-Randomized StudyKarow J et al.Journal of pain & palliative care pharmacotherapy2026Clinical Trial
Clinical Efficacy of Adjunctive Photodynamic Therapy with Periodontal Regenerative Surgery in Severe Periodontitis: A Randomized Controlled Trial on Gingival Thickness Remodeling and Inflammatory Cytokine ModulationHuang D et al.Photobiomodulation, photomedicine, and laser surgery2026Randomized Controlled Trial
An intraoperative methylene blue test can guide patient selection for totally tubeless PCNLLee J et al.medRxiv : the preprint server for health sciences2026Preprint
A two-center comparison of the efficacy of methylene blue and hydroxocobalamin for the treatment of refractory shockLeung NY et al.Perfusion2026Observational Study
Evaluating the Impact of a Standardized Protocol for Managing Refractory Vasoplegia After Cardiopulmonary BypassTeletnick A et al.Journal of cardiothoracic and vascular anesthesia2026Observational Study
The effect of methylene blue infiltrating injection on anal pain after Milligan-Morgan surgery: A randomized controlled clinical studyZhu J et al.Medicine2026Randomized Controlled Trial
Discovery of fluorescent properties in mitoxantrone hydrochloride injection for tracing: application for sentinel lymph node biopsy in breast cancerLi X et al.World journal of surgical oncology2026Randomized Controlled Trial
Photodynamic Therapy Plus Topical Corticosteroid for Erosive Oral Lichen Planus: A Randomized Clinical TrialWang Z et al.International dental journal2026Randomized Controlled Trial
Early Methylene Blue for Mortality Reduction in High-Dose VasoPREssor-Dependent Septic Shock (EMPRESS): protocol for a multicenter randomized controlled trialLuo JC et al.Scandinavian journal of trauma, resuscitation and emergency medicine2026Clinical Study
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's diseaseWischik CM et al.The journal of prevention of Alzheimer's disease2026Randomized Controlled Trial
Effect of photodynamic therapy on postoperative pain after pulpectomy in paediatric patients under general dental anaesthesia: A randomised controlled trialZhang M et al.Photodiagnosis and photodynamic therapy2026Randomized Controlled Trial
Intraoperative methylene blue infusion reduces postoperative delirium in patients undergoing pancreatic surgery: A randomized controlled clinical trialDeng Y et al.Journal of clinical anesthesia2026Randomized Controlled Trial
Preoperative contrast-enhanced ultrasound combined with intra-lymph node methylene blue injection for sentinel lymph node identification: a minimally invasive sentinel lymph node biopsy tracing approachLiu Y et al.European radiology2026Randomized Controlled Trial
Serratus Anterior Plane Block with Methylene Blue and Ropivacaine for Analgesia in Prosthetic Breast Augmentation: A Randomized Controlled TrialZhang T et al.Plastic and reconstructive surgery2026Randomized Controlled Trial
The Effect of Methylene Blue on Sublingual Microcirculation in Patients with Septic Shock: A Randomized Controlled TrialDong C et al.Drug design, development and therapy2025Randomized Controlled Trial
The clinical value of nanocarbon suspension and methylene blue in sentinel lymphatic tracing and pathologic fine sorting of penile cancer: a multicentre prospective studyLiu C et al.Annals of medicine2025Randomized Controlled Trial
Patient and donor antibody profiles in early COVID-19 convalescent plasma therapy in the COnV-ert trialAlemany A et al.Frontiers in immunology2025Randomized Controlled Trial
Development and evaluation of a novel prehospital antidote service providing methylthioninium chloride (methylene blue) for sodium nitrite poisoningDavies G et al.Emergency medicine journal : EMJ2025Observational Study
Redefining scar quality: A synergistic approach with micro-needling and photodynamic therapy using methylene blue as a photosensitizer: a randomized clinical trialSabetghadam M et al.Photodiagnosis and photodynamic therapy2025Randomized Controlled Trial
Adjunctive methylene blue-based antimicrobial photodynamic therapy in the re-instrumentation of residual periodontal pockets in individuals with down syndrome: A randomized controlled clinical trialPetrilli PH et al.Journal of dentistry2025Randomized Controlled Trial
IMPACT OF PHOTODYNAMIC THERAPY ON ORAL HEALTH IN PATIENTS UNDERGOING FIXED ORTHODONTIC TREATMENT: A RANDOMIZED CONTROLLED TRIALBerisha N et al.Georgian medical news2025Randomized Controlled Trial
Effect of intraoperative methylene blue on postoperative delirium in elderly patients undergoing joint replacement: a randomized controlled trialZhang W et al.International journal of surgery (London, England)2025Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Methylene blue (non-peptide stack partner)?

Described as an electron cycler, not just a dye.

How many registered human trials study Methylene blue (non-peptide stack partner)?

The PeptideWhiz trial index lists 135 registered trials for Methylene blue (non-peptide stack partner), the most recent from 2027.

How much published research exists on Methylene blue (non-peptide stack partner)?

The PeptideWhiz paper index links 458 PubMed papers to Methylene blue (non-peptide stack partner); by study type, 6425 human and 5458 animal studies.

Which conditions is Methylene blue (non-peptide stack partner) researched for?

Fatigue & low energy (incl. midlife), Cognition, focus & brain performance, Multiple sclerosis, Migraine, Dementia, Alzheimer's & cognitive decline, Autism support, Gum disease (periodontal) & oral health, Pregnancy and breastfeeding: safety notes, Anemia, Diabetic retinopathy and glaucoma, Acne, Anti-aging & longevity, Atherosclerosis, cardiovascular disease & high blood pressure, Candida & persistent bacterial infections, Celiac disease and gluten sensitivity, Chronic and systemic inflammation, EBV and reactivated viruses, Fatty liver & elevated liver enzymes, Fight-or-flight and nervous system overdrive, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Hemorrhoids and fissures, Herpes (HSV) and cold sores, Hyperparathyroidism, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Low blood pressure and orthostatic hypotension, Lymphedema and swelling, Osteoarthritis, cartilage loss & avoiding joint replacement, Osteoporosis and bone density, Post-surgical inflammation and surgery recovery, Psoriasis and psoriatic arthritis, Recurring UTIs, Rheumatoid arthritis, Skin, hair loss, wounds & mast-cell/histamine reactivity, Tendon, ligament, muscle & joint injuries (incl. athletes), Thyroid problems.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).