What is Vitamin D, K2, Magnesium and Zinc?

Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library · · Human Trials · What are peptides?

57 registered trials · 96 indexed papers · 2331 human / 968 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What the Notes Say

Educational notes on Vitamin D, K2, Magnesium and Zinc, restating how it is described in research notes. Not guidance for any person.

Magnesium is described as required for AMPK to function.
The heart is described as depending on precise potassium and magnesium balance for electrical function.
Zinc is described as a cofactor for the enzymes that make growth hormone.
Vitamin D3 and K2 are discussed together so that calcium does not end up in the arteries.
Magnesium is characterized as a natural NMDA receptor antagonist.

Registered human trials (57)

Trial	Phase	Status	Year	Enrolled
The OK Daily Study		not yet recruiting	2026	134
The Role of Vitamin K on Knee Osteoarthritis Outcomes	Phase 1/Phase 2	active not recruiting	2025	49
Ischemic Stroke Nutrition Intervention Study		active not recruiting	2025	190
The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation	Phase 4	recruiting	2025	20
The Skin Anti-Aging Effects of Vitamin K2 (MK-7): a Clinical Split-Face/Neck Trial		completed	2024	36
Vitamin K2 Supplementation in Adult Episodic Migraine		recruiting	2024	160
A Pilot Study of Vitamin K2 (Menaquinone-7, Soloways ™) in Patients With Osteopenia/Osteoporosis Carrying a VDR Gene Variant		recruiting	2024	40
The DANish COronary DEcalcification (DANCODE) Trial		completed	2023	400
Role of Vitamin K2 in Chronic Kidney Disease	Phase 4	recruiting	2023	44
Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity		completed	2023	51
The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health		active not recruiting	2022	450
Effect of Vitamin K2 in the Treatment of Nocturnal Leg Cramps in Older Population		completed	2022	200
Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers		completed	2022	151
Vitamin K2 and Muscle Weakness in Type 2 Diabetes		unknown	2022	150
Antioxidant and Immune Effects of Vitamin K2		completed	2022	60
Dietary Supplements for COVID-19	Phase 3	terminated	2021	90
viTAmin K2 and rEcOVery From ExeRcise		completed	2021	80
Randomized Controlled Clinical Trial to Investigate Effects of Vitamin K2 in COVID-19		completed	2021	40
Vitamin K2 Supplements for Muscle Recovery		unknown	2021	60
Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients	Phase 2/Phase 3	completed	2020	40
A Clinical Trial of Epizon-701 (EPN-701) in Subjects With End-Stage Renal Disease (ESRD)	Phase 2	completed	2019	18
SLOW-Slower Progress of caLcificatiOn With Vitamin K2		unknown	2019	200
MaxSimil and Vitamin K2: Determining Their Bioavailability		completed	2019	22
Effect of Vitamin K 2 on Vascular Calcification in Hemodialysis Patients	Phase 2/Phase 3	unknown	2019	60
The Aortic Valve DECalcification (AVADEC) Trial		completed	2018	389
Decalcification of the Aortic Valve by Vitamin K2 (Menaquinone-7)	Phase 2	unknown	2018	150
Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients		unknown	2017	60
Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K	Phase 2	completed	2016	178
Effect of Vitamin K2 (MK7) on Cardiovascular and Bone Disease in Dialysis Patients	Phase 4	completed	2016	123
Vitamin K to Slow Progression of Dyslipidemia and Diabetes Risk (Vita-K 'n' Kids Study II)		unknown	2016	30
A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes		completed	2016	68
Vitamin K2 for Reduction the Calcium at Carotid Bifurcation in Patients With Subcritical Lesions		completed	2016	60
Vitamin K2 Effect on Vascular Stiffening in Subjects With a Poor Vitamin K-status		unknown	2016	240
Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI	Phase 2	unknown	2016	44
Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?	Phase 4	completed	2016	50
Vitamin K as Additive Treatment in Osteoporosis	Phase 2/Phase 3	unknown	2015	105
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)		unknown	2015	30
Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients	Phase 4	completed	2015	117
Vitamin K2 Supplementation and Arterial Stiffness in the Renal Transplant Population (The KING Trial)	Phase 2	completed	2015	60
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)		unknown	2013	30

Peer-reviewed studies (96)

Paper	Authors	Journal	Year	Type
Longitudinal Height Growth Patterns Among Children Receiving Menaquinone-7 Supplementation	Nguyen ND et al.	Nutrients	2026	Observational Study
Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial	Vossen LM et al.	JAMA cardiology	2026	Randomized Controlled Trial
The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial	Lithgow H et al.	Medicine and science in sports and exercise	2026	Randomized Controlled Trial
Non-Fat Fermented Milk Enhanced the Bioavailability of Fat-Soluble Vitamins in Humans: A Crossover Study	Morifuji M et al.	Journal of nutritional science and vitaminology	2026	Randomized Controlled Trial
Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial	Hasific S et al.	Atherosclerosis	2025	Randomized Controlled Trial
Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women	de Vries F et al.	Nutrients	2025	Randomized Controlled Trial
Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis	Zhang Z et al.	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2025	Randomized Controlled Trial
Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial	Tan J et al.	JAMA internal medicine	2024	Randomized Controlled Trial
No Detectable Coagulation Activation After Vitamin K (MK-7) Supplementation in Patients on Dialysis With Functional Vitamin K Deficiency: A One-Year Randomized, Placebo-Controlled Study	Bladbjerg EM et al.	Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation	2024	Randomized Controlled Trial
The effect of six-month oral vitamin K supplementation on calcification propensity time in individuals with type 2 diabetes mellitus: A post hoc analysis of a randomized, double-blind, placebo-controlled trial	Meer R et al.	Atherosclerosis	2024	Randomized Controlled Trial
Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial	Naiyarakseree N et al.	Nutrients	2023	Randomized Controlled Trial
Study protocol of the InterVitaminK trial: a Danish population-based randomised double-blinded placebo-controlled trial of the effects of vitamin K (menaquinone-7) supplementation on cardiovascular, metabolic and bone health	Kampmann FB et al.	BMJ open	2023	Clinical Study
The study of bioavailability and endogenous circadian rhythm of menaquinone-7, a form of vitamin K(2,) in healthy subjects	Du F et al.	The British journal of nutrition	2023	Randomized Controlled Trial
Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults-the TAKEOVER study	Lithgow H et al.	Trials	2022	Clinical Study
Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial	Tarkesh F et al.	BMC women's health	2022	Randomized Controlled Trial
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial	Diederichsen ACP et al.	Circulation	2022	Randomized Controlled Trial
The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial	Karamzad N et al.	Nutrition & diabetes	2022	Randomized Controlled Trial
Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial	Xu D et al.	Nutrition (Burbank, Los Angeles County, Calif.)	2022	Randomized Controlled Trial
Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders	Zhang W et al.	Spine	2022	Controlled Clinical Trial
The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial	El Borolossy R et al.	European journal of clinical nutrition	2022	Randomized Controlled Trial
Fat-Soluble Vitamin Supplementation Using Liposomes, Cyclodextrins, or Medium-Chain Triglycerides in Cystic Fibrosis: A Randomized Controlled Trial	Nowak JK et al.	Nutrients	2021	Randomized Controlled Trial
Effects of vitamin K2 supplementation on atherogenic status of individuals with type 2 diabetes: a randomized controlled trial	Rahimi Sakak F et al.	BMC complementary medicine and therapies	2021	Randomized Controlled Trial
Safety and Efficacy of Vitamin K Antagonists versus Rivaroxaban in Hemodialysis Patients with Atrial Fibrillation: A Multicenter Randomized Controlled Trial	De Vriese AS et al.	Journal of the American Society of Nephrology : JASN	2021	Randomized Controlled Trial
Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial	Rønn SH et al.	European journal of clinical nutrition	2021	Randomized Controlled Trial
Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study	Solmaz I et al.	Journal of pediatric endocrinology & metabolism : JPEM	2021	Randomized Controlled Trial
Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study	Zhang Y et al.	Calcified tissue international	2020	Randomized Controlled Trial
Vitamin K2 Status and Arterial Stiffness Among Untreated Migraine Patients: A Case-Control Study	Mansour AG et al.	Headache	2020	Observational Study
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study	De Vriese AS et al.	Journal of the American Society of Nephrology : JASN	2020	Randomized Controlled Trial
The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial	Oikonomaki T et al.	International urology and nephrology	2019	Randomized Controlled Trial
The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial	Zwakenberg SR et al.	The American journal of clinical nutrition	2019	Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Vitamin D, K2, Magnesium and Zinc?

Magnesium is described as required for AMPK to function.

How many registered human trials study Vitamin D, K2, Magnesium and Zinc?

The PeptideWhiz trial index lists 57 registered trials for Vitamin D, K2, Magnesium and Zinc, the most recent from 2026.

How much published research exists on Vitamin D, K2, Magnesium and Zinc?

The PeptideWhiz paper index links 96 PubMed papers to Vitamin D, K2, Magnesium and Zinc; by study type, 2331 human and 968 animal studies.

Which conditions is Vitamin D, K2, Magnesium and Zinc researched for?

Anemia, Atherosclerosis, cardiovascular disease & high blood pressure, Fatigue & low energy (incl. midlife), Fight-or-flight and nervous system overdrive, Skin sensitivity and body aches on GLP-1 medicines, Gum disease (periodontal) & oral health, Heart repair: after heart attack, heart failure & enlarged heart, Herpes (HSV) and cold sores, High cholesterol and statins, Hyperparathyroidism, Insulin resistance, prediabetes & type 2 diabetes, Lipedema, Low testosterone (without or alongside TRT), Male fertility and sperm, Migraine, Muscle gain, sarcopenia & building muscle after 40, PMDD (premenstrual dysphoric disorder), Raynaud's, Rheumatoid arthritis, Sexual function & libido (women and men), Skin, hair loss, wounds & mast-cell/histamine reactivity, Sleep apnea (obstructive), Sleep problems (incl. insomnia on peptides), Swollen feet and ankles, Thyroid problems, Anti-aging & longevity, Chronic and systemic inflammation, Concussion, traumatic brain injury & stroke recovery, Fat loss, obesity & body recomposition, Immune system (general), Kidney protection (CKD, diabetic kidney, lupus kidney), Loose skin, Lung health, asthma & COPD, Osteoporosis and bone density, PCOS, Pregnancy and breastfeeding: safety notes, SIBO, Thick blood and blood clots.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).