What is Nafarelin?
A GnRH analog nasal spray (Synarel) used in endometriosis and early puberty.
Nafarelin in the library · · Human Trials · What are peptides?
10 registered trials · 91 indexed papers · 95 human / 1 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A GnRH analog nasal spray (Synarel) used in endometriosis and early puberty.
Type: GnRH analog peptide.
Definition (National Library of Medicine)
“A potent synthetic agonist of gonadotropin-releasing hormone with 3-(2-naphthyl)-D-alanine substitution at residue 6.”
- MeSH: Nafarelin
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Nafarelin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (10)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Intranasal Nafarelin For Triggering Oocyte Maturation | Phase 4 | recruiting | 2026 | 154 |
| GnRH for Luteal Support - Mechanism of Action | recruiting | 2026 | 150 | |
| Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone | EARLY_Phase 1 | not yet recruiting | 2025 | 150 |
| Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI Cycles | Phase 3 | recruiting | 2024 | 652 |
| Injection Free IVF | Phase 2 | withdrawn | 2021 | |
| GnRH Agonist for Luteal Phase Support. | unknown | 2020 | 150 | |
| Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders | Phase 4 | unknown | 2017 | 100 |
| Protocol to Minimize Injections and Blood Draws for Women Undergoing in Vitro Fertilization | completed | 2016 | 4 | |
| Natural Versus HRT Cycles in Frozen Embryo Replacement Treatment | Phase 4 | completed | 2009 | 159 |
| Endometriosis : Traditional Medicine vs Hormone Therapy | Phase 1/Phase 2 | completed | 2002 | 50 |
Peer-reviewed studies (91)
More cited research
- Nafarelin acetate for pituitary down-regulation in in vitro fertilization. Comparison of two dosages (1995, human observational)
- GnRH agonists: gonadorelin, leuprolide and nafarelin (1991, human observational)
- A comparative treatment trial of endometriosis using the gonadotrophin-releasing hormone agonist, nafarelin, and the synthetic steroid, danazol (None, human RCT)
Conditions researched
- Endometriosis
- Female fertility
- Low testosterone (without or alongside TRT)
- Male fertility and sperm
- Menopause & perimenopause
- Osteoporosis and bone density
- PCOS
- Post-surgical inflammation and surgery recovery
- Pregnancy and breastfeeding: safety notes
Related compounds
- Leuprolide
- Goserelin
- Triptorelin
- hCG (human chorionic gonadotropin)
- ACTH (Corticotropin)
- Parathyroid Hormone (PTH 1-84)
- Buserelin
- Degarelix
- Kisspeptin-10
- Vasopressin
FAQ
What is Nafarelin?
A GnRH analog nasal spray (Synarel) used in endometriosis and early puberty.
How many registered human trials study Nafarelin?
The PeptideWhiz trial index lists 10 registered trials for Nafarelin, the most recent from 2026.
How much published research exists on Nafarelin?
The PeptideWhiz paper index links 91 PubMed papers to Nafarelin; by study type, 95 human and 1 animal studies.
Which conditions is Nafarelin researched for?
Endometriosis, Female fertility, Low testosterone (without or alongside TRT), Male fertility and sperm, Menopause & perimenopause, Osteoporosis and bone density, PCOS, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).