What is Pentagastrin?
A synthetic 5-unit peptide that mimics gastrin; historically used to test stomach acid secretion.
Pentagastrin in the library · · Human Trials · What are peptides?
1 registered trials · 222 indexed papers · 246 human / 41 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A synthetic 5-unit peptide that mimics gastrin; historically used to test stomach acid secretion.
Type: Synthetic peptide.
Definition (National Library of Medicine)
“A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.”
- MeSH: Pentagastrin
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Pentagastrin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (1)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| A New Method for Determining Gastric Acid Output Using a Wireless Capsule | completed | 2008 | 80 |
Peer-reviewed studies (222)
More cited research
- Stimulation of vasoactive intestinal peptide and neurotensin secretion by pentagastrin in a patient with VIPoma syndrome (1994, human case report)
- Effects of vasoactive intestinal peptide on resting and pentagastrin-stimulated lower esophageal sphincter pressure (1978, human observational)
- A comparison of the effects of intravenous pentagastrin on patients with social phobia, panic disorder and healthy controls (None, human trial (non-randomized))
- Pituitary adenylate cyclase activating polypeptide-27 (PACAP-27) inhibits pentagastrin-stimulated gastric acid secretion in conscious rats (1992, animal)
- Vasoactive intestinal peptide-associated inhibition of stimulated gastric secretion. II. Inhibition of pentagastrin-stimulated gastric secretion (1980, animal)
- Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious (2009, animal)
- Inhibitory effect of sorbin on pepsin secretion in conscious cats and rabbits (2000, animal)
Conditions researched
- Anemia
- Anxiety and panic
- Delayed gastric emptying on GLP-1 medicines
- Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers
- Immune system (general)
- Post-surgical inflammation and surgery recovery
- Thyroid problems
Related compounds
- ACTH (Corticotropin)
- CRH (Corticotropin-Releasing Hormone)
- Exenatide
- Ghrelin
- Glucagon
- Octreotide
- Oxytocin
- Somatostatin
- ANP (Atrial Natriuretic Peptide)
- Angiotensin II
FAQ
What is Pentagastrin?
A synthetic 5-unit peptide that mimics gastrin; historically used to test stomach acid secretion.
How many registered human trials study Pentagastrin?
The PeptideWhiz trial index lists 1 registered trial for Pentagastrin, the most recent from 2008.
How much published research exists on Pentagastrin?
The PeptideWhiz paper index links 222 PubMed papers to Pentagastrin; by study type, 246 human and 41 animal studies.
Which conditions is Pentagastrin researched for?
Anemia, Anxiety and panic, Delayed gastric emptying on GLP-1 medicines, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Immune system (general), Post-surgical inflammation and surgery recovery, Thyroid problems.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).