What is Romiplostim?

A peptide-antibody fusion (peptibody) that activates the thrombopoietin receptor to raise platelet counts; sold as Nplate.

Romiplostim in the library · · Human Trials · What are peptides?

106 registered trials · 106 indexed papers · 110 human / 0 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A peptide-antibody fusion (peptibody) that activates the thrombopoietin receptor to raise platelet counts; sold as Nplate.

Type: Peptibody (thrombopoietin receptor agonist).

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Romiplostim is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (106)

TrialPhaseStatusYearEnrolled
A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)Phase 2recruiting2026164
Combination Therapy of Romiplostim and Erythropoiesis-stimulating AgentsPhase 2recruiting202612
Efficacy and Safety of Romiplostim N01 for Injection in Promoting Platelet Reconstitution After Allogeneic Hematopoietic Stem Cell TransplantationPhase 2not yet recruiting202687
A Study of Romiplostim Plus Predniso(lo)ne vs. Predniso(lo)ne Alone for the Treatment of Previously Untreated Primary Immune Thrombocytopenia (ITP)Phase 3recruiting2026126
Romiplostim N01 for Injection for Secondary Prophylaxis of CIT in Breast CancerPhase 2not yet recruiting202653
Preoperative Use of Romiplostim in Thrombocytopenic Patients Undergoing Cardiac Surgery.Phase 2recruiting2026136
Atorvastatin Combined With NAC Plus Romiplostim for Management of ITPnot yet recruiting202650
CsA+EPAG/HPAG+Romiplostim N01 in the Treatment of Newly-diagnosed SAA/TD-NSAAPhase 2withdrawn2026
Romiplostim N01 in the Treatment of Refractory Chemoradiotherapy-induced AAPhase 2withdrawn2026
Romiplostim for Oral TPO-RA Resistant ITPrecruiting202660
A Multicenter Clinical Study of Romiplostim N01 in the Treatment of Sepsis-related ThrombocytopeniaPhase 1not yet recruiting2026280
Romiplostim N01 in Chemoradiotherapy-induced Aplastic AnemiaPhase 2not yet recruiting202643
CsA+EPAG/HPAG+Romiplostim N01 in Newly-diagnosed SAA/TD-NSAAPhase 2not yet recruiting202643
Romiplostim Versus rhTPO for Platelet Engraftment After Transplant in MDS and AAPhase 2recruiting202666
Phase II Study of Orelabrutinib in Combination With Romiplostim N01 in Patients With Primary Immune Thrombocytopenia (ITP) Who Have Received At Least One Prior Line of TherapyPhase 2not yet recruiting202628
A Study of Romiplostim N01 Plus IST vs. Placebo Plus IST for Treatment-Naive Severe Aplastic AnemiaPhase 3not yet recruiting2026210
UI-Romi-02; Romiplostim Added to Standard of Care for Treatment Naive and Relapsed or Refractory Severe Aplastic AnemiaPhase 2withdrawn2025
Efficacy and Safety Study of Romiplostim N01 for Cancer Treatment-induced Thrombocytopenia (CTIT) in the Treatment of LeukemiaPhase 2recruiting202597
Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gastrointestinal Solid TumorsPhase 2recruiting2025220
Romiplostim N01 Plus ATRA for Persistent Isolated Chemotherapy-Induced Thrombocytopenia After Complete Remission of Gynecologic, Breast, or Lung Solid TumorsPhase 2recruiting2025220
Romiplostim N01 for Chemotherapy-Induced Thrombocytopenia in Pediatric Cancer PatientsPhase 2recruiting202550
A Study on the Treatment of CTIT of the Efficacy and Safety With Romiplostim N01 Compared to Recombinant Human Interleukin-11Phase 3recruiting202588
Romiplostim N01 for Platelet Recovery After Haploidentical HSCTPhase 1recruiting2025130
Efficacy and Safety of Romiplostim N01 Combined With Rituximab in Patients With Oral TPO-RA-Refractory Primary Immune Thrombocytopeniarecruiting202530
Safety and Efficacy of Romiplostim in Treatment of Chronic ITP in Childrennot yet recruiting2025100
A Multicenter, Open-label, Randomized Controlled Trial Evaluating the Efficacy and Safety of Romiplostim N01 in the Treatment of Thrombocytopenia Associated With Concurrent/Sequential Chemoradiotherapy and Chemotherapy Combined With/Without Immunotherapy in Solid Tumorsnot yet recruiting2025106
Romiplostim N01 in the Treatment of Thrombocytopenia Caused by Cytotoxic Drugs in Breast Cancer Patientsnot yet recruiting202568
Romiplostim N01 for the Treatment of Thrombocytopenia Associated With Radiotherapy-Combined Treatment Regimens in Patients With Solid TumorsPhase 2not yet recruiting202560
Romiplostim N01 for Chemotherapy-induced ThrombocytopeniaPhase 2recruiting202550
Romiplostim N01 Combined With Glucocorticoids as the First-line Treatment for Newly Diagnosed Adult Primary Immune Thrombocytopenia: A Multicenter, Interventional TrialPhase 2recruiting2025129
High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With SplenomegalyPhase 2recruiting202430
Observational Study: Romiplostim for Platelet Recovery in Haploidentical HSCTcompleted202416
Single Arm Romiplostim to Prevent CITEARLY_Phase 1recruiting202426
Study on Glucocorticoid Combined With Gamma Globulin and Ropristine N01 in Treatment of Initial Severe ITPPhase 2unknown202436
Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic AnemiaPhase 2unknown202448
Romiplostim N01 for Platelet Recovery in Adult Hematologic Malignancies Patients Undergoing UCBTPhase 2recruiting202434
A Study of Romiplostim N01 as the First-line Treatment for Newly Diagnosed Adult Patients With ITPPhase 2unknown2024129
A Study of Romiplostim for the Treatment of Refractory Transfusion-dependent NSAAPhase 4unknown202440
Ropustin for Refractory Aplastic Anaemia After Radiotherapy - a Single-centre, Prospective, Open-label, Single-arm StudyPhase 4unknown202440
A Multicenter Randomized Controlled Study on the Treatment of Refractory CTIT With Romiplostim N01 Compared to Recombinant Human ThrombopoietinPhase 3unknown202460

Peer-reviewed studies (106)

PaperAuthorsJournalYearType
Single-center experience with Romiplostim N01 for the management of severe persistent cancer therapy-induced thrombocytopenia in lung cancer: Insights and outcomesWang C et al.Medicine2026Observational Study
Hematopoietic Recovery and Safety Following Early Romiplostim Administration After Pediatric HSCT: A Prospective Randomized Pilot StudySarangarajan S et al.Pediatric blood & cancer2026Randomized Controlled Trial
Evaluation of Safety and Efficacy of Romiplostim in the Treatment of Pediatric Immune Thrombocytopenia: A Real-World Observational StudyAttia SA et al.Journal of pediatric hematology/oncology2026Observational Study
Switching patients with immune thrombocytopenia (ITP) to avatrombopag from other thrombopoietin receptor agonists: The real-world experience of the Spanish ITP Group (GEPTI)Pascual-Izquierdo C et al.British journal of haematology2026Observational Study
Romiplostim versus Placebo for Chemotherapy-Induced ThrombocytopeniaAl-Samkari H et al.The New England journal of medicine2026Randomized Controlled Trial
Efficacy and Safety of Romiplostim in Treating Thrombocytopenia after Hematopoietic Stem Cell Transplantation in Pediatric Patients: A Single-Arm Clinical TrialKarimizadeh Z et al.Transplantation and cellular therapy2026Clinical Trial
Combining an immunomodulatory drug with a TPO-RA to treat multirefractory ITP patients: The Spanish ITP Group experienceMingot-Castellano ME et al.British journal of haematology2026Observational Study
Evaluation of the efficacy and safety of initial high-dose romiplostim for primary immune thrombocytopenia in the acute care settingBringhurst G et al.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis2026Observational Study
Romiplostim, low-dose rituximab and high-dose dexamethasone for newly diagnosed immune thrombocytopenia: A pilot studyColunga-Pedraza PR et al.British journal of haematology2026Clinical Trial
Romiplostim with ciclosporin A in patients with aplastic anaemia naïve to immunosuppressive therapy: A phase 2/3 studyLee JW et al.British journal of haematology2025Clinical Trial, Phase III
Romiplostim versus Recombinant human thrombopoietin in umbilical cord blood transplantation: a single-center retrospective studyDing Y et al.Annals of hematology2025Randomized Controlled Trial
Predictive factors of romiplostim response in patients with refractory aplastic anemia: data from two clinical trialsJang JH et al.Annals of hematology2025Clinical Trial, Phase III
The 'Stop TPO-RA in ITP Patients' study: Clinical and immune modulatory effects of romiplostim taperingNelson VS et al.British journal of haematology2025Clinical Trial
Safety, efficacy, and treatment satisfaction in adults with ITP who switched to avatrombopag from another TPO-RATarantino MD et al.Blood advances2025Clinical Trial, Phase IV
Long-term safety and effectiveness of romiplostim for chronic idiopathic thrombocytopenic purpura in real-world settingsObara N et al.International journal of hematology2024Observational Study
Romiplostim for Treatment of Children and Young Adults With Severe Aplastic Anemia and Myelodysplastic SyndromeSharathkumar A et al.Journal of pediatric hematology/oncology2024Observational Study
Real-world use of thrombopoietin receptor agonists for the management of immune thrombocytopenia in adult patients in the United Kingdom: Results from the TRAIT studyCooper N et al.British journal of haematology2024Observational Study
Long-term efficacy and safety of romiplostim in refractory aplastic anemia: follow-up of a phase 2/3 studyMitani K et al.Blood advances2024Clinical Trial, Phase III
A randomized, double-blind, comparative study of the pharmacodynamics and pharmacokinetics of GP40141 (romiplostim biosimilar) and reference romiplostim in healthy male volunteersMakarenko I et al.Pharmacology research & perspectives2023Randomized Controlled Trial
Transient increase in platelet counts associated with COVID-19 infection during TPO-RA as the second-line treatment in children with ITPWang Z et al.British journal of haematology2023Observational Study
Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trialKurita N et al.Annals of hematology2023Clinical Trial, Phase I
Efficacy and safety of biosimilar romiplostim in Indian patients with chronic immune thrombocytopenia: A multicentric retrospective studyIqbal A et al.Indian journal of pathology & microbiology2023Observational Study
A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopeniaGrainger J et al.Blood advances2023Clinical Trial, Phase III
Tapering of the thrombopoietin receptor agonist in paediatric patients with chronic immune thrombocytopenia: Is it possible?Solsona M et al.British journal of clinical pharmacology2022Observational Study
Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US studyAl-Samkari H et al.British journal of haematology2022Observational Study
Romiplostim for Primary Immune Thrombocytopenia in Routine Clinical Practice: Results from a Multicentre Observational Study in GermanyReiser M et al.Acta haematologica2022Observational Study
Pharmacokinetics, Safety, and Pharmacodynamics of Romiplostim in Chinese Subjects With Immune Thrombocytopenia: A Phase I/II TrialQi J et al.Clinical pharmacology in drug development2022Clinical Trial, Phase II
Effectiveness and safety of romiplostim among patients with newly diagnosed, persistent and chronic ITP in routine clinical practice in central and Eastern Europe: an analysis of the PLATON studySkopec B et al.Hematology (Amsterdam, Netherlands)2021Observational Study
Real-world use of thrombopoietin receptor agonists in older patients with primary immune thrombocytopeniaPalandri F et al.Blood2021Observational Study
Phase I Dose-Finding, Safety, and Tolerability Trial of Romiplostim to Improve Platelet Recovery After UCB TransplantationChristakopoulos GE et al.Transplantation and cellular therapy2021Clinical Trial, Phase I

More cited research

Conditions researched

Related compounds

FAQ

What is Romiplostim?

A peptide-antibody fusion (peptibody) that activates the thrombopoietin receptor to raise platelet counts; sold as Nplate.

How many registered human trials study Romiplostim?

The PeptideWhiz trial index lists 106 registered trials for Romiplostim, the most recent from 2026.

How much published research exists on Romiplostim?

The PeptideWhiz paper index links 106 PubMed papers to Romiplostim; by study type, 110 human and 0 animal studies.

Which conditions is Romiplostim researched for?

Anemia, Fatty liver & elevated liver enzymes, Immune system (general), Kidney protection (CKD, diabetic kidney, lupus kidney), Pregnancy and breastfeeding: safety notes, Thick blood and blood clots.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research