What is Teriparatide?

A parathyroid hormone fragment, PTH(1-34), with human trials and approved-pen labeling; the research vial is not the approved pen.

Teriparatide in the library · Healing & Repair Peptides · Human Trials · What are peptides?

153 registered trials · 421 indexed papers · 1764 human / 295 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Teriparatide is described as rhPTH(1-34), with human trials and approved labeling behind it. The research-vial calculation is described as not interchangeable with the approved teriparatide pen, and pen handling instructions are formulation-specific.

Research context (as described)

  • The research context includes the DATA and DATA-Switch trials examining combined and sequenced teriparatide and denosumab therapy (Leder et al., 2014, PMID 24517156; Leder et al., 2015, PMID 26144908), and the Endocrine Society and AACE guidelines on postmenopausal osteoporosis (Eastell et al., 2019, PMID 30907953; Camacho et al., 2020, PMID 32427503).

Registered human trials (153)

TrialPhaseStatusYearEnrolled
PROactive HEALing in High-Risk Pelvic and Non-hip Lower Extremity Fragility Fractures (PRO HEAL Pilot)Phase 1/Phase 2not yet recruiting202754
Combined Anabolic TherapyPhase 4recruiting202550
Bone Turnover Markers and Treatment Efficacy in Postmenopausal Osteoporosiscompleted202540
Chronotherapeutic Optimization of Teriparatide Administration in Postmenopausal Osteoporosisnot yet recruiting202528
To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of FracturePhase 3not yet recruiting2025282
Precision Medicine Approach for Osteoporosis - Follow Up StudyPhase 4enrolling by invitation202440
A Study of TeriQ Patch in Healthy Adult Female ParticipantsPhase 1completed202424
Sequential Therapies After Osteoanabolic Treatmentrecruiting2023150
Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous ForteoPhase 1completed202345
Study of the Key Techniques of Prevention and Treatment of Osteoporotic Refracturerecruiting20232478
Teriparatide on Maxillary Sinus Floor OsseointegrationPhase 4unknown202342
Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone TurnoverPhase 4active not recruiting202260
Fracture Recovery for Returning to Duty (Teriparatide STRONG)Phase 4enrolling by invitation2022183
Study Evaluating PK of PTH Administered Orally Via RaniPill™ CapsulePhase 1completed202250
To Evaluate the Efficacy and Safety of SAL056 for Postmenopausal Women With Osteoporosis at High Fracture RiskPhase 3completed2021493
Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Chronic Kidney DiseasePhase 4recruiting202148
Real-world Effectiveness and Cardiovascular Safety Study of Abaloparatide in Postmenopausal Womencompleted202122054
Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).Phase 3completed202120
Pharmacokinetic and PHarmacodynamic Analysis and Evaluation of Teriparatide (PTH 1-34) Between SexesPhase 3completed202130
Weekly Use of Teriparatide to Accelerate Healing of Distal Radius FracturePhase 2unknown202180
Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin on the Bone Metabolism and Agingterminated202099
Replication of the VERO Osteoporosis Trial in Healthcare Claims Datacompleted202012757
Efficacy of WJ-derived Mesenchymal Stem Cells in Combination With Parathyroid Hormone for Vertebral Compression FracturePhase 2unknown202030
Novel Combination Therapy for Osteoporosis in MenPhase 4completed201940
Preoperative Teriparatide Use on Insertional Torque of Pedicle Screws for Lumbar Fusion Surgeryactive not recruiting2019192
Bone Modeling Effects of Combined Anabolic/Antiresorptive AdministrationPhase 4completed201937
A Six-month Phase 2 Study of Oral hPTH(1-34) (EBP05) in Postmenopausal Women With Low Bone MassPhase 2completed2019161
Circulating Myokine Levels and Bone Metabolismcompleted2019220
Study of Teriparatide in Stress Fracture HealingPhase 3unknown2019136
Examination How the Administration Period of Teriparatide Affects Bone Metabolism and Bone Mineral Density Prior to Denosumab TherapyPhase 2unknown201890
G56W1 in Women With Postmenopausal OsteoporosisPhase 1/Phase 2unknown2018148
The Effect of Teriparatide on Bone Union in Unstable Intertrochanteric Fracture Patients Treated With PFNAPhase 3completed201750
Teriparatide as a Chondroregenerative Therapy in OAPhase 2completed201776
MiDeTe - microRNA Levels Under Denosumab and Teriparatide Therapy in Postmenopausal OsteoporosisPhase 4completed201726
PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled TrialPhase 2completed201735
Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary HypoparathyroidismPhase 2completed201716
Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysiscompleted2017200
Comparation of Treatment Strategies for OVF: Teriparatide Injection and PVPactive not recruiting201790
Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic AcidPhase 4completed2016350
A Comparison of PF708 and Forteo in Osteoporosis PatientsPhase 3completed2016181

Peer-reviewed studies (421)

PaperAuthorsJournalYearType
Real-world treatment outcomes in pregnancy and lactation-associated osteoporosis: a nationwide multicenter cohort studySözen M et al.Frontiers in endocrinology2026Observational Study
Evaluation of teriparatide as a promoter of mandibular fracture healing: An observational clinical studyRajan TA et al.Chinese journal of traumatology = Zhonghua chuang shang za zhi2026Observational Study
Teriparatide Plus Zoledronic Acid for Osteogenesis Imperfecta: A Randomized Clinical TrialHald JD et al.JAMA2026Randomized Controlled Trial
Effects of romosozumab on bone strength around a pedicle screw as evaluated by biomechanical computed tomography-based virtual stress tests in postmenopausal womenKeaveny TM et al.The spine journal : official journal of the North American Spine Society2026Randomized Controlled Trial
A clinical study on the effects of teriparatide and denosumab on bone metabolism and gut microbiota in osteoporotic fracture patientsDeng J et al.Archives of osteoporosis2026Clinical Trial
Baseline serum PINP is associated with early lumbar spine bone mineral density gains during twice-weekly teriparatide treatment: the OASIS cohort studyNiimi R et al.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026Observational Study
Malignant transformation in patients with monoclonal gammopathy of undetermined significance treated with teriparatide for osteoporosis: a bicenter retrospective study and analysis of the French national pharmacovigilance databaseCassez R et al.Archives of osteoporosis2026Observational Study
Efficacy of sequential denosumab after teriparatide for 6 months compared with denosumab monotherapy in reducing risk of osteoporotic fractures in patients with new fractures: a multicentre randomised controlled trial (STAND study) protocolChi Y et al.BMJ open2026Clinical Study
Effects of teriparatide on hip structure and bone microarchitecture in women with anorexia nervosa: a placebo-controlled randomized trialAmorim T et al.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026Randomized Controlled Trial
Continuous subcutaneous administration of teriparatide as a therapeutic option in chronic hypoparathyroidism: retrospective study in three tertiary care centers of the epi-hypo studyAttia A et al.European journal of endocrinology2026Observational Study
Bone density and remodeling after discontinuation of sequential therapy for premenopausal idiopathic osteoporosisCohen A et al.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026Clinical Trial, Phase II
Adherence and persistence of daily and twice-weekly teriparatide treatment in postmenopausal women with high-risk of fractureMochizuki T et al.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry2026Randomized Controlled Trial
Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot TrialPrasad TN et al.The Journal of clinical endocrinology and metabolism2026Randomized Controlled Trial
Comparative bone histomorphometry effects of combined denosumab and teriparatide vs monotherapy in postmenopausal women with osteoporosis: a randomized controlled trialRamchand SK et al.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2026Randomized Controlled Trial
Baseline Characteristics of the TOPaZ Study: Randomised Trial of Teriparatide and Zoledronic Acid Compared with Standard Care in Adults with Osteogenesis ImperfectaHald JD et al.Calcified tissue international2025Randomized Controlled Trial
Sequential anti-osteoporotic therapy with teriparatide and alendronate optimizes outcomes of percutaneous vertebroplasty in acute osteoporotic vertebral fractures: a 12-month prospective cohort studyXie Y et al.BMC musculoskeletal disorders2025Observational Study
Impact of standard versus cyclic teriparatide and denosumab treatment on trabecular bone score: a post-hoc analysis of a randomized clinical trialDash AS et al.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025Randomized Controlled Trial
Randomized crossover comparison of two teriparatide self-injection regimens for primary osteoporosis: final report of the Japanese Osteoporosis Intervention Trial 06 (JOINT-06)Tanaka S et al.Journal of bone and mineral metabolism2025Randomized Controlled Trial
Time-dependent improvement of quality of life with teriparatide or alendronate therapy: a JOINT-05 sub-analysisMori S et al.Journal of bone and mineral metabolism2025Randomized Controlled Trial
Timing optimization of teriparatide dosing for postmenopausal osteoporosis: a randomized controlled trialWang H et al.Journal of orthopaedic surgery and research2025Randomized Controlled Trial
Anti-resorptive and anabolic therapies improve Falls Risk Assessment Score (FRAS) in postmenopausal women with type 2 diabetes mellitusPrasad TN et al.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025Randomized Controlled Trial
A randomized controlled trial of teriparatide for accelerating bone union and improving clinical outcomes in patients with pertrochanteric fracture fixationTanavalee C et al.Scientific reports2025Randomized Controlled Trial
Evaluation of the fracture prevention effects of teriparatide and alendronate in patients with frailty: a sub-analysis of the Japanese osteoporosis intervention trial-05Hosoi T et al.Journal of bone and mineral metabolism2025Randomized Controlled Trial
Comparative effectiveness of romosozumab versus teriparatide for fracture prevention: A new-user, active comparator designTominaga R et al.Bone2025Observational Study
Probability of achieving bone mineral density treatment targets with abaloparatide and teriparatideCosman F et al.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2025Randomized Controlled Trial
An oral robotic pill reliably and safely delivers teriparatide with high bioavailability in healthy volunteers: A phase 1 studyMyers JT et al.British journal of clinical pharmacology2025Clinical Trial, Phase I
A Random Study of Comparing the Efficacy of Antiosteoporosis Therapy at Different Time Points Combined With Oblique Lateral Interbody Fusion in the Treatment of Lumbar Degenerative Disease Patients Complicated With OsteoporosisZhao H et al.Clinical spine surgery2025Randomized Controlled Trial
Perioperative teriparatide for preventing proximal junctional kyphosis and failure in patients with osteoporosis after adult thoracolumbar spinal deformity surgery: a prospective randomized controlled trialPark JH et al.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025Randomized Controlled Trial
Randomized crossover comparison of two teriparatide self-injection regimens for primary osteoporosis: Interim report (end of 52-week treatment) of the Japanese Osteoporosis Intervention Trial 06 (JOINT-06)Soen S et al.Journal of bone and mineral metabolism2025Randomized Controlled Trial
Efficacy and safety of teriparatide in kidney transplant recipients with osteoporosis and low bone turnover: a real-world experienceVetrano D et al.International urology and nephrology2025Observational Study

More cited research

Conditions researched

Related compounds

FAQ

What is Teriparatide?

A parathyroid hormone fragment, PTH(1-34), with human trials and approved-pen labeling; the research vial is not the approved pen.

How many registered human trials study Teriparatide?

The PeptideWhiz trial index lists 153 registered trials for Teriparatide, the most recent from 2027.

How much published research exists on Teriparatide?

The PeptideWhiz paper index links 421 PubMed papers to Teriparatide; by study type, 1764 human and 295 animal studies.

Which conditions is Teriparatide researched for?

Anemia, Anti-aging & longevity, Endometriosis, Gum disease (periodontal) & oral health, Hyperparathyroidism, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Kidney protection (CKD, diabetic kidney, lupus kidney), Menopause & perimenopause, Osteoarthritis, cartilage loss & avoiding joint replacement, Osteoporosis and bone density, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Rheumatoid arthritis, Skin, hair loss, wounds & mast-cell/histamine reactivity.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research