What is Secretin?
A 27-amino-acid gut hormone that triggers pancreatic secretion; used as a diagnostic agent in pancreatic function testing.
Secretin in the library · · Human Trials · What are peptides?
37 registered trials · 169 indexed papers · 329 human / 632 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A 27-amino-acid gut hormone that triggers pancreatic secretion; used as a diagnostic agent in pancreatic function testing.
Type: Gut peptide hormone.
Definition (National Library of Medicine)
“A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (usan and the usp Dictionary of Drug Names, 1994, p597)”
- MeSH: Secretin
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Secretin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (37)
Peer-reviewed studies (169)
More cited research
- Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone (2017, human observational)
- The secretin G-protein-coupled receptor family: teleost receptors (2005, human observational)
- Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo (2002, human observational)
- Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor (1996, human observational)
- Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and secretin stimulation of PAK4 and activation of Na+,K+-ATPase in pancreatic acinar cells (2019, animal)
- Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice (2019, animal)
- Secretin is not necessary for exocrine pancreatic development and growth in mice (2011, animal)
- Secretin mRNA in the subdivision of primary sensory neurons in the trigeminal ganglion of rats (2011, animal)
Conditions researched
- Anemia
- Autism support
- Fat loss, obesity & body recomposition
- Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers
- Insulin resistance, prediabetes & type 2 diabetes
- Lung health, asthma & COPD
- Pancreatitis (after the acute phase)
- Post-surgical inflammation and surgery recovery
- Sleep problems (incl. insomnia on peptides)
Related compounds
- Glutathione
- Carnosine
- L-Carnitine
- Oxytocin
- Cyanocobalamin (Vitamin B12)
- Octreotide
- Semaglutide
- Therapeutic nicotine (patch, non-peptide)
- ACTH (Corticotropin)
- BNP (Nesiritide)
FAQ
What is Secretin?
A 27-amino-acid gut hormone that triggers pancreatic secretion; used as a diagnostic agent in pancreatic function testing.
How many registered human trials study Secretin?
The PeptideWhiz trial index lists 37 registered trials for Secretin, the most recent from 2026.
How much published research exists on Secretin?
The PeptideWhiz paper index links 169 PubMed papers to Secretin; by study type, 329 human and 632 animal studies.
Which conditions is Secretin researched for?
Anemia, Autism support, Fat loss, obesity & body recomposition, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Insulin resistance, prediabetes & type 2 diabetes, Lung health, asthma & COPD, Pancreatitis (after the acute phase), Post-surgical inflammation and surgery recovery, Sleep problems (incl. insomnia on peptides).
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).