What is Teduglutide (GLP-2 analog)?

A GLP-2 analog approved for short bowel syndrome (Gattex/Revestive); it helps the remaining gut absorb more and lowers IV nutrition needs.

Teduglutide (GLP-2 analog) in the library · Healing & Repair Peptides · Human Trials · What are peptides?

41 registered trials · 29 indexed papers · 6 human / 0 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Teduglutide is described as a 33-amino-acid GLP-2 analog with one amino-acid change that resists DPP-4 breakdown.

Mechanism (as described)

  • It activates GLP-2 receptors, promoting intestinal villus growth and absorption.

Evidence (as described)

  • In short bowel syndrome it reduced parenteral support needs. Analyses also reported less diarrhea in children (Fifi et al., 2023) and improved liver tests (Micic et al., 2024).

Status

FDA-approved (2012) and EMA-approved for short bowel syndrome.

Registered human trials (41)

TrialPhaseStatusYearEnrolled
Glucagon-like Peptide 2 (GLP-2) in Undernourished Women Improving From Histology-Confirmed Environmental Enteric Dysfunction (EED)Phase 2not yet recruiting202655
A Study of Teduglutide in Chinese Adults With Short Bowel SyndromePhase 3active not recruiting202513
TED_ORG: Study on Short Bowel Syndromerecruiting202450
Pilot Study to Investigate the Effect of Teduglutide on Temporary Ileostomy Function and ComplicationsPhase 3withdrawn2022
A Study of Teduglutide in Japanese Children With Short Bowel Syndrome Aged 4 Months or OlderPhase 3completed20223
A Study to Evaluate the Bioavailability of Teduglutide Administered Subcutaneously by Syringe Injection Versus Pen Injector in Healthy Adult ParticipantsPhase 1completed202164
Pediatric Teduglutide Registrycompleted2021142
A Study of Teduglutide in Japanese People With Short Bowel Syndromecompleted2021250
Therapeutic Approaches to Malnutrition EnteropathyPhase 2completed2020125
Quality of Life in Patients With Short Bowel Syndrome Treated Without and With Teduglutide - a Prospective Nested Matched Pair Analysisunknown202040
Teduglutide for Enterocutaneous Fistula (ECF)Phase 2completed20196
Glucagon-like Peptide-2 Mediated Secretion of Stored Enteral LipidsPhase 2/Phase 3completed201921
Bridging Intestinal Failure With Teduglutide - a Case Reportcompleted20191
Plasma Lipoprotein Response to Glucagon-like Peptide-2Phase 2/Phase 3completed201810
Characterization of the Long-term Safety, Efficacy, and Pharmacodynamics Revestive® in the Management of Short Bowel Syndrome Pediatric PatientsPhase 4completed201825
Safety, Efficacy and Pharmacokinetic Study of Teduglutide in Infants 4 to 12 Months of Age With Short Bowel SyndromePhase 3completed201810
An Extension Study of Teduglutide in Japanese Participants With Short Bowel Syndrome Who Completed 24 Weeks of Treatment in SHP633-306 or TED-C14-004Phase 3completed201811
Study of Teduglutide in Japanese Participants With Short Bowel SyndromePhase 3completed20187
Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dependent on Parenteral SupportPhase 3completed201710
A Study in Japanese Children With Short Bowel Syndrome Who Completed SHP633-302Phase 3completed20179
L-NMMA on GLP-2 Mediated Intestinal Lipoprotein ReleasePhase 2/Phase 3completed201710
Treatment of Patients With Teduglutide (GLP-2) for GVHD and Analysis of Paneth Cells of GVHD PatientsEARLY_Phase 1completed20176
Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral NutritionPhase 3completed201659
Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 StudyPhase 3completed201629
Teduglutide in Short Bowel Syndrome Patientscompleted201617
A Study of the Gut Barrier and Blood Vessel Inflammation in Individuals With and Without HIVPhase 2completed201532
Short Bowel Syndrome and Teduglutide Versus PlaceboPhase 4completed20148
Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Teduglutide in Japanese Subjects With PN-dependent Short Bowel Syndrome (SBS)Phase 3completed201411
A Pharmacokinetic, Safety, and Pharmacodynamic Study of Teduglutide in Pediatric Subjects With Short Bowel SyndromePhase 3completed201342
A One-Year, Open-Label Study With Teduglutide for Subjects Who Completed Study CL0600-021Phase 3completed201214
Effect of Teduglutide on Gastric Emptying in Healthy SubjectsPhase 1completed201036
Open-Label Study of Teduglutide for Subjects With PN-Dependent Short Bowel Syndrome (SBS)Phase 3completed200988
Pharmacokinetics of [amount hidden] Teduglutide in Subjects With Renal Impairment Compared to Healthy Subjects With Normal Renal FunctionPhase 1completed200936
Effects of Teduglutide on Cardiac Repolarisation and Conduction in Healthy Male and Female VolunteersPhase 1completed200972
Study of Teduglutide Effectiveness in Parenteral Nutrition (PN)-Dependent Short Bowel Syndrome (SBS) SubjectsPhase 3completed200886
Pharmacokinetics (PK) of [amount hidden] Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy ParticipantsPhase 1completed200724
A Double-Blind Multi-Dose Tolerability and Pharmacokinetic Study of TeduglutidePhase 1completed200695
Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Who Completed Protocol CL0600-004 (NCT00081458)Phase 3completed200565
Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel SyndromePhase 3completed200484
Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease Who Completed Protocol CL0600-008Phase 2completed200467

Peer-reviewed studies (29)

PaperAuthorsJournalYearType
Quality of life for pediatric patients with short bowel syndrome-associated intestinal failure treated with teduglutideWendel D et al.Journal of pediatric gastroenterology and nutrition2026Randomized Controlled Trial
Teduglutide in pediatric patients under 10 kg with short bowel syndrome on parenteral support: An open-label studyMasumoto K et al.Pediatrics international : official journal of the Japan Pediatric Society2026Clinical Trial, Phase III
Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regenerationSturgeon JP et al.EBioMedicine2025Randomized Controlled Trial
Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trialChandwe K et al.Nature communications2024Randomized Controlled Trial
Teduglutide improves liver chemistries in short bowel syndrome-associated intestinal failure: Post hoc analysisMicic D et al.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2024Randomized Controlled Trial
Effects of Teduglutide on Diarrhea in Pediatric Patients with Short Bowel Syndrome-Associated Intestinal FailureFifi A et al.Journal of pediatric gastroenterology and nutrition2023Clinical Trial, Phase III
Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral SupportChiba M et al.Journal of pediatric gastroenterology and nutrition2023Randomized Controlled Trial
Efficacy, safety, and pharmacokinetics of teduglutide in adult Japanese patients with short bowel syndrome and intestinal failure: two phase III studies with an extensionNakamura S et al.Surgery today2023Clinical Trial, Phase III
Teduglutide for the treatment of low-output enterocutaneous fistula - A pilot randomized controlled studyYeh DD et al.Clinical nutrition ESPEN2022Randomized Controlled Trial
Predictors and timing of response to teduglutide in patients with short bowel syndrome dependent on parenteral supportChen K et al.Clinical nutrition ESPEN2021Clinical Trial, Phase III
Citrulline correlations in short bowel syndrome-intestinal failure by patient stratification: Analysis of 24 weeks of teduglutide treatment from a randomized controlled studyJeppesen PB et al.Clinical nutrition (Edinburgh, Scotland)2020Randomized Controlled Trial
Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal FailureChen K et al.JPEN. Journal of parenteral and enteral nutrition2020Randomized Controlled Trial
Glucagon-like peptide-2 mobilizes lipids from the intestine by a systemic nitric oxide-independent mechanismXiao C et al.Diabetes, obesity & metabolism2019Randomized Controlled Trial
Reduction of Parenteral Nutrition and Hydration Support and Safety With Long-Term Teduglutide Treatment in Patients With Short Bowel Syndrome-Associated Intestinal Failure: STEPS-3 StudySeidner DL et al.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2018Randomized Controlled Trial
Factors Associated With Response to Teduglutide in Patients With Short-Bowel Syndrome and Intestinal FailureJeppesen PB et al.Gastroenterology2018Randomized Controlled Trial
Independence From Parenteral Nutrition and Intravenous Fluid Support During Treatment With Teduglutide Among Patients With Intestinal Failure Associated With Short Bowel SyndromeIyer KR et al.JPEN. Journal of parenteral and enteral nutrition2017Randomized Controlled Trial
Outcomes from a 12-Week, Open-Label, Multicenter Clinical Trial of Teduglutide in Pediatric Short Bowel SyndromeCarter BA et al.The Journal of pediatrics2017Clinical Trial, Phase III
Patients With Short Bowel on Narcotics During 2 Randomized Trials Have Abdominal Complaints Independent of TeduglutideFujioka K et al.JPEN. Journal of parenteral and enteral nutrition2017Randomized Controlled Trial
Acute Effects of a Glucagon-Like Peptide 2 Analogue, Teduglutide, on Gastrointestinal Motor Function and Permeability in Adult Patients With Short Bowel Syndrome on Home Parenteral NutritionIturrino J et al.JPEN. Journal of parenteral and enteral nutrition2016Randomized Controlled Trial
A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjectsBerg JK et al.BMC gastroenterology2014Randomized Controlled Trial
Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled studyJeppesen PB et al.Clinical nutrition (Edinburgh, Scotland)2013Randomized Controlled Trial
Teduglutide enhances structural adaptation of the small intestinal mucosa in patients with short bowel syndromeTappenden KA et al.Journal of clinical gastroenterology2013Randomized Controlled Trial
Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failureO'Keefe SJ et al.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2013Randomized Controlled Trial
Pharmacokinetics of teduglutide in subjects with renal impairmentNave R et al.European journal of clinical pharmacology2013Controlled Clinical Trial
Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failureJeppesen PB et al.Gastroenterology2012Randomized Controlled Trial
Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndromeJeppesen PB et al.Gut2011Randomized Controlled Trial
Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's diseaseBuchman AL et al.Inflammatory bowel diseases2010Randomized Controlled Trial
Pharmacokinetics, safety, and tolerability of teduglutide, a glucagon-like peptide-2 (GLP-2) analog, following multiple ascending subcutaneous administrations in healthy subjectsMarier JF et al.Journal of clinical pharmacology2008Randomized Controlled Trial
Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patientsJeppesen PB et al.Gut2005Clinical Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Teduglutide (GLP-2 analog)?

A GLP-2 analog approved for short bowel syndrome (Gattex/Revestive); it helps the remaining gut absorb more and lowers IV nutrition needs.

How many registered human trials study Teduglutide (GLP-2 analog)?

The PeptideWhiz trial index lists 41 registered trials for Teduglutide (GLP-2 analog), the most recent from 2026.

How much published research exists on Teduglutide (GLP-2 analog)?

The PeptideWhiz paper index links 29 PubMed papers to Teduglutide (GLP-2 analog); by study type, 6 human and 0 animal studies.

Which conditions is Teduglutide (GLP-2 analog) researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Delayed gastric emptying on GLP-1 medicines, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, High cholesterol and statins, Immune system (general), Kidney protection (CKD, diabetic kidney, lupus kidney), Post-surgical inflammation and surgery recovery.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).

Reported dosing ranges from research