What is CNP (C-Type Natriuretic Peptide)?

A natriuretic peptide involved in bone growth and blood vessel tone; vosoritide is an analog.

CNP (C-Type Natriuretic Peptide) in the library · · Human Trials · What are peptides?

1 registered trials · 48 indexed papers · 57 human / 13 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A natriuretic peptide involved in bone growth and blood vessel tone; vosoritide is an analog.

Type: Natriuretic peptide.

Definition (National Library of Medicine)

“A peptide of 22 amino acids, derived mainly from cells of vascular endothelium. It is also found in the brain, major endocrine glands, and other tissues. It shares structural homology with atrial natriuretic factor. It has vasorelaxant activity thus is important in the regulation of vascular tone and blood flow. Several high molecular weight forms containing the 22 amino acids have been identified.”

  • MeSH: Natriuretic Peptide, C-Type

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when CNP (C-Type Natriuretic Peptide) is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (1)

TrialPhaseStatusYearEnrolled
The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vesselswithdrawn2020

Peer-reviewed studies (48)

PaperAuthorsJournalYearType
Real-World Outcomes of Vosoritide Treatment in Chinese Children with Achondroplasia: The Retrospective Cohort COREV StudyChen L et al.Advances in therapy2026Observational Study
Navepegritide combined with lonapegsomatropin for the treatment of children with achondroplasia: 52-week results from the phase 2 COACH trialMcDonnell CM et al.European journal of endocrinology2026Randomized Controlled Trial
Viral suppression is associated with rising NT-proCNP levels and reduced systemic inflammation in people living with HIVBojti I et al.Infection2026Observational Study
A phase II basket trial of vosoritide in children with RASopathies, ACAN, and NPR2 deficiencyDauber A et al.The Journal of clinical endocrinology and metabolism2026Clinical Trial, Phase II
Development of Muscle Function in Children with Achondroplasia Under Vosoritide Treatment: A Retrospective Single-Centre Observational StudyReincke S et al.Journal of musculoskeletal & neuronal interactions2026Observational Study
Once-Weekly Navepegritide in Children With Achondroplasia: The APPROACH Randomized Clinical TrialSavarirayan R et al.JAMA pediatrics2026Randomized Controlled Trial
Effect of Vosoritide Therapy on IGF-I and Endogenous C-Type Natriuretic Peptide in HypochondroplasiaKanakatti Shankar R et al.The Journal of clinical endocrinology and metabolism2026Clinical Trial, Phase II
Phase 2 Trial of Vosoritide Use in Patients with Hypochondroplasia: A Pharmacokinetic/Pharmacodynamic AnalysisGaletaki D et al.Hormone research in paediatrics2026Clinical Trial, Phase II
Sustained growth-promoting effects of vosoritide in children with achondroplasia from an ongoing phase 3 extension studySavarirayan R et al.Med (New York, N.Y.)2025Randomized Controlled Trial
Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trialSavarirayan R et al.The Lancet. Child & adolescent health2024Randomized Controlled Trial
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamics results of a long-acting C-type natriuretic peptide prodrug, TransCon CNPBreinholt VM et al.British journal of clinical pharmacology2022Randomized Controlled Trial
Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young MenThonsgaard S et al.Clinical chemistry2022Randomized Controlled Trial
Pharmacokinetics and Exposure-Response of Vosoritide in Children with AchondroplasiaChan ML et al.Clinical pharmacokinetics2022Randomized Controlled Trial
Safe and persistent growth-promoting effects of vosoritide in children with achondroplasia: 2-year results from an open-label, phase 3 extension studySavarirayan R et al.Genetics in medicine : official journal of the American College of Medical Genetics2021Randomized Controlled Trial
Rationale, design, and methods of a randomized, controlled, open-label clinical trial with open-label extension to investigate the safety of vosoritide in infants, and young children with achondroplasia at risk of requiring cervicomedullary decompression surgerySavarirayan R et al.Science progress2021Clinical Study
Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trialSavarirayan R et al.Lancet (London, England)2020Randomized Controlled Trial
Patient-Associated Predictors of 15- and 30-Day Readmission After Hospitalization for Acute Heart FailureDelgado JF et al.Current heart failure reports2019Observational Study
C-Type Natriuretic Peptide Analogue Therapy in Children with AchondroplasiaSavarirayan R et al.The New England journal of medicine2019Clinical Trial, Phase II
Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathyEhler J et al.Neuroscience letters2019Observational Study
Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trialGarg AX et al.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2018Randomized Controlled Trial
Clinical and hemodynamic improvements after adding ambrisentan to background PDE5i therapy in patients with pulmonary arterial hypertension exhibiting a suboptimal therapeutic response (ATHENA-1)Shapiro S et al.Respiratory medicine2017Clinical Trial
Neurohumoral Modulation During Waon Therapy in Chronic Heart Failure - Subanalysis of Waon-CHF StudyIchiki T et al.Circulation journal : official journal of the Japanese Circulation Society2017Clinical Trial, Phase III
Dynamic response of C-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short statureOlney RC et al.Clinical endocrinology2016Observational Study
Associations of circulating natriuretic peptides with haemodynamics in precapillary pulmonary hypertensionKaiser R et al.Respiratory medicine2015Observational Study
C-type natriuretic peptide plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasiaOlney RC et al.The Journal of clinical endocrinology and metabolism2015Observational Study
Prognostic value of N-terminal pro C-type natriuretic peptide in heart failure patients with preserved and reduced ejection fractionLok DJ et al.European journal of heart failure2014Randomized Controlled Trial
C-type natriuretic peptide in complicated pregnancy: increased secretion precedes adverse eventsReid RA et al.The Journal of clinical endocrinology and metabolism2014Observational Study
Concomitant assessment of PSP and NT-proCNP as predictive markers of sepsis in severe trauma patients under mechanical ventilationGouel-Chéron A et al.Critical care (London, England)2013Observational Study
Measurement of amino-terminal propeptide of C-type natriuretic peptide in patients with idiopathic short stature or isolated growth hormone deficiencyXiao Y et al.Journal of pediatric endocrinology & metabolism : JPEM2011Randomized Controlled Trial
Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjectsLee CY et al.Journal of clinical pharmacology2009Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is CNP (C-Type Natriuretic Peptide)?

A natriuretic peptide involved in bone growth and blood vessel tone; vosoritide is an analog.

How many registered human trials study CNP (C-Type Natriuretic Peptide)?

The PeptideWhiz trial index lists 1 registered trial for CNP (C-Type Natriuretic Peptide), the most recent from 2020.

How much published research exists on CNP (C-Type Natriuretic Peptide)?

The PeptideWhiz paper index links 48 PubMed papers to CNP (C-Type Natriuretic Peptide); by study type, 57 human and 13 animal studies.

Which conditions is CNP (C-Type Natriuretic Peptide) researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Heart repair: after heart attack, heart failure & enlarged heart, Immune system (general), Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes, Skin, hair loss, wounds & mast-cell/histamine reactivity.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).