What is Neurotensin?

A 13-amino-acid peptide found in the brain and gut; studied in a small number of human trials.

Neurotensin in the library · · Human Trials · What are peptides?

6 registered trials · 54 indexed papers · 184 human / 357 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 13-amino-acid peptide found in the brain and gut; studied in a small number of human trials.

Type: Neuropeptide.

Definition (National Library of Medicine)

“A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.”

  • MeSH: Neurotensin

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Neurotensin is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (6)

TrialPhaseStatusYearEnrolled
Assessment the Diagnostic Value of Pro-Neurotensin as a Serum Biomarker in MASLDunknown202480
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palateunknown202066
Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.unknown201935
Neurotensin Infusions in Healthy Individuals -completed20199
Neurotensin - an Important Regulator of Appetite in Humans?unknown201818
A Study of 18F-AlF-NOTA-Neurotensin PET/CT for Imaging Prostate CancerPhase 1/Phase 2unknown201865

Peer-reviewed studies (54)

PaperAuthorsJournalYearType
Serum Neurotensin Levels in Vitiligo Patients: A Comparative Study with Correlation to Disease Activity and Severity. A Case-Control StudyElnemr M et al.La Clinica terapeutica2026Observational Study
Tai Chi rehabilitation program enhances blood pressure control and modulates inflammatory and Brain-Gut peptides in hypertensionFang H et al.BMC complementary medicine and therapies2026Randomized Controlled Trial
Micro-RNAs-122 and Pro-neurotensin biomarker for non-invasive diagnosis of Non-alcoholic fatty liver disease (A Case control study)Ghazy AM et al.La Clinica terapeutica2025Observational Study
Increased meal-induced neurotensin response predicts successful maintenance of weight loss - Data from a randomized controlled trialBrethvad AO et al.Metabolism: clinical and experimental2023Randomized Controlled Trial
The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensinBennet L et al.BMC endocrine disorders2022Randomized Controlled Trial
Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patientsWerida RH et al.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022Randomized Controlled Trial
Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-upFawad A et al.The Journal of clinical endocrinology and metabolism2022Observational Study
Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric BypassJonsson I et al.Frontiers in endocrinology2021Randomized Controlled Trial
Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in childrenBarchetta I et al.Nutrition, metabolism, and cardiovascular diseases : NMCD2021Observational Study
The association between plasma proneurotensin and glucose regulation is modified by country of birthFawad A et al.Scientific reports2019Observational Study
The immediate effects of cervical spine manipulation on pain and biochemical markers in females with acute non-specific mechanical neck pain: a randomized clinical trialLohman EB et al.The Journal of manual & manipulative therapy2019Randomized Controlled Trial
The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgeryvon Loeffelholz C et al.International journal of obesity (2005)2018Randomized Controlled Trial
The role of neurotensin as a novel biomarker in the endoscopic screening of high-risk population for developing colorectal neoplasiaKontovounisios C et al.Updates in surgery2017Clinical Trial
Phase IA Clinical Trial Evaluating the Tolerability, Pharmacokinetics, and Analgesic Efficacy of an Intrathecally Administered Neurotensin A Analogue in Central Neuropathic Pain Following Spinal Cord InjurySang CN et al.Clinical pharmacology in drug development2016Clinical Trial, Phase I
Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes MellitusChowdhury S et al.PloS one2016Controlled Clinical Trial
Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgerySterl K et al.Peptides2016Clinical Trial, Phase I
The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humansMandøe MJ et al.The American journal of clinical nutrition2015Randomized Controlled Trial
Regulation of nutrition-associated receptors in blood monocytes of normal weight and obese humansPivovarova O et al.Peptides2015Clinical Trial
Changes in biochemical markers of pain perception and stress response after spinal manipulationPlaza-Manzano G et al.The Journal of orthopaedic and sports physical therapy2014Randomized Controlled Trial
Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetesChowdhury S et al.American journal of physiology. Gastrointestinal and liver physiology2014Randomized Controlled Trial
Appetite-regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workersSchiavo-Cardozo D et al.Clinical endocrinology2013Observational Study
Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetesWice BM et al.Diabetes2012Clinical Trial
[99mTc]demotensin VI: biodistribution and initial clinical results in tumor patients of a pilot/phase I studyGabriel M et al.Cancer biotherapy & radiopharmaceuticals2011Clinical Trial, Phase I
Effects of a diet with inulin-enriched pasta on gut peptides and gastric emptying rates in healthy young volunteersRusso F et al.European journal of nutrition2011Randomized Controlled Trial
Effects of cerebrolysin on moderate cognitive impairments in cerebral vascular insufficiency (a clinical-electrophysiological study)Damulin IV et al.Neuroscience and behavioral physiology2008Clinical Trial
Voglibose inhibits postprandial hypotension in neurologic disorders and elderly peopleMaruta T et al.Neurology2006Controlled Clinical Trial
Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson diseaseMesnage V et al.Clinical neuropharmacology2004Randomized Controlled Trial
Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorderMeltzer HY et al.The American journal of psychiatry2004Randomized Controlled Trial
Effect of neurotensin on colorectal motor and sensory function in humansvan der Veek PP et al.Diseases of the colon and rectum2004Clinical Trial
Neurotensin pulmonary metabolism in normal and asthmatic subjectsVacca P et al.European review for medical and pharmacological sciences2003Controlled Clinical Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Neurotensin?

A 13-amino-acid peptide found in the brain and gut; studied in a small number of human trials.

How many registered human trials study Neurotensin?

The PeptideWhiz trial index lists 6 registered trials for Neurotensin, the most recent from 2024.

How much published research exists on Neurotensin?

The PeptideWhiz paper index links 54 PubMed papers to Neurotensin; by study type, 184 human and 357 animal studies.

Which conditions is Neurotensin researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Delayed gastric emptying on GLP-1 medicines, Fat loss, obesity & body recomposition, Fatty liver & elevated liver enzymes, Gallbladder and gallstones, Insulin resistance, prediabetes & type 2 diabetes, Low blood pressure and orthostatic hypotension, Parkinson's disease, Post-surgical inflammation and surgery recovery, Skin, hair loss, wounds & mast-cell/histamine reactivity.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).