What is Pancreatic Polypeptide?

A 36-amino-acid pancreatic hormone in the same family as peptide YY and neuropeptide Y.

Pancreatic Polypeptide in the library · · Human Trials · What are peptides?

5 registered trials · 194 indexed papers · 397 human / 127 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 36-amino-acid pancreatic hormone in the same family as peptide YY and neuropeptide Y.

Type: Peptide hormone.

Definition (National Library of Medicine)

“A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the islets of langerhans and adjacent to cells containing somatostatin and glucagon. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with obesity in rats and mice.”

  • MeSH: Pancreatic Polypeptide

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Pancreatic Polypeptide is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (5)

TrialPhaseStatusYearEnrolled
Pancreatic Polypeptide as a Modulator of Amylin- Induced Satiety in Healthy Humansrecruiting202618
Safety, Tolerability and Efficacy Study of PP1420 in HVPhase 1/Phase 2terminated201449
A First-Time-in-Human Study to Assess the Safety and Tolerability of PP 1420 in Healthy SubjectsPhase 1completed201013
Effect of Pancreatic Polypeptide on Gastric Motor Function and Food Intake in HumansPhase 4completed201012
The Effect of Pancreatic Polypeptide on Insulin Requirements for Type 1 & Post-pancreatectomy Diabetic PatientsPhase 2terminated20078

Peer-reviewed studies (194)

PaperAuthorsJournalYearType
Satiety responsiveness following dietary exposure to ultra-processed foods differing in texture-derived eating rate: a secondary analysis of a randomized controlled crossover diet interventionvan Bruinessen M et al.European journal of nutrition2026Randomized Controlled Trial
Physiological Impact of Right Gastric Artery Ligation During SADI-S: A Prospective Randomized Exploratory StudyPereira AM et al.Obesity surgery2026Randomized Controlled Trial
Appetite regulation following energy restriction with almond-enriched vs. nut-free diets - a randomised controlled trialCarter S et al.Obesity research & clinical practice2026Randomized Controlled Trial
Enteroendocrine hormonal response after the ingestion of cola beverages with sucrose and non-nutritive sweeteners in healthy adults: A randomized crossover trialGalicia-Ayala C et al.Nutrition (Burbank, Los Angeles County, Calif.)2026Randomized Controlled Trial
Supraphysiological effects of pancreatic polypeptide on gastric motor function and nutrient tolerance in humansVerbeure W et al.Physiological reports2021Randomized Controlled Trial
Urinary Dopamine Excretion Rate Decreases during Acute Dietary Protein Deprivation and Is Associated with Increased Plasma Pancreatic Polypeptide ConcentrationBasolo A et al.Nutrients2021Clinical Trial
The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgeryMartinussen C et al.American journal of physiology. Endocrinology and metabolism2020Randomized Controlled Trial
Dairy products influence gut hormone secretion and appetite differently: A randomized controlled crossover trialHansson P et al.Journal of dairy science2020Randomized Controlled Trial
Whey Proteins Reduce Appetite, Stimulate Anorexigenic Gastrointestinal Peptides and Improve Glucometabolic Homeostasis in Young Obese WomenRigamonti AE et al.Nutrients2019Randomized Controlled Trial
Postprandial Effects of Blueberry (Vaccinium angustifolium) Consumption on Glucose Metabolism, Gastrointestinal Hormone Response, and Perceived Appetite in Healthy Adults: A Randomized, Placebo-Controlled Crossover TrialStote K et al.Nutrients2019Randomized Controlled Trial
Low subjective socioeconomic status stimulates orexigenic hormone ghrelin - A randomised trialSim AY et al.Psychoneuroendocrinology2018Randomized Controlled Trial
Novel essential amino acid supplements enriched with L-leucine facilitate increased protein and energy intakes in older women: a randomised controlled trialIspoglou T et al.Nutrition journal2017Randomized Controlled Trial
Abdominal vagus nerve stimulation as a new therapeutic approach to prevent postoperative ileusStakenborg N et al.Neurogastroenterology and motility2017Randomized Controlled Trial
The effect of meal frequency in a reduced-energy regimen on the gastrointestinal and appetite hormones in patients with type 2 diabetes: A randomised crossover studyBelinova L et al.PloS one2017Randomized Controlled Trial
Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humansTamboli RA et al.Diabetes, obesity & metabolism2017Randomized Controlled Trial
The effect of moderate versus severe simulated altitude on appetite, gut hormones, energy intake and substrate oxidation in menMatu J et al.Appetite2017Randomized Controlled Trial
Acute effects of glucagon-like peptide-1, GLP-1(9-36 amide), and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteersBremholm L et al.Physiological reports2017Randomized Controlled Trial
Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitisPendharkar SA et al.Cytokine2017Clinical Trial
Effect of heat exposure and exercise on food intake regulation: A randomized crossover study in young healthy menFaure C et al.Metabolism: clinical and experimental2016Randomized Controlled Trial
Beyond expectations: the physiological basis of sensory enhancement of satietyYeomans MR et al.International journal of obesity (2005)2016Controlled Clinical Trial
Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes MellitusChowdhury S et al.PloS one2016Controlled Clinical Trial
Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgerySterl K et al.Peptides2016Clinical Trial, Phase I
The Effects of a Hypocaloric Diet on Diet-Induced Thermogenesis and Blood Hormone Response in Healthy Male Adults: A Pilot StudyIshii S et al.Journal of nutritional science and vitaminology2016Randomized Controlled Trial
Cephalic phase secretion of insulin and other enteropancreatic hormones in humansVeedfald S et al.American journal of physiology. Gastrointestinal and liver physiology2016Clinical Trial
Effect of two bakery products on short-term food intake and gut-hormones in young adults: a pilot studySantaliestra-Pasías AM et al.International journal of food sciences and nutrition2015Randomized Controlled Trial
Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in HumansMennella I et al.The Journal of nutrition2015Randomized Controlled Trial
Effects of High-Intensity Intermittent Exercise Training on Appetite RegulationSim AY et al.Medicine and science in sports and exercise2015Randomized Controlled Trial
Counterregulatory responses to hypoglycemia differ between glimepiride and glyburide in non diabetic individualsJoy NG et al.Metabolism: clinical and experimental2015Randomized Controlled Trial
Dietary whey protein influences plasma satiety-related hormones and plasma amino acids in normal-weight adult womenChungchunlam SM et al.European journal of clinical nutrition2015Randomized Controlled Trial
Energy intake over 2 days is unaffected by acute sprint interval exercise despite increased appetite and energy expenditureBeaulieu K et al.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2015Controlled Clinical Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Pancreatic Polypeptide?

A 36-amino-acid pancreatic hormone in the same family as peptide YY and neuropeptide Y.

How many registered human trials study Pancreatic Polypeptide?

The PeptideWhiz trial index lists 5 registered trials for Pancreatic Polypeptide, the most recent from 2026.

How much published research exists on Pancreatic Polypeptide?

The PeptideWhiz paper index links 194 PubMed papers to Pancreatic Polypeptide; by study type, 397 human and 127 animal studies.

Which conditions is Pancreatic Polypeptide researched for?

Delayed gastric emptying on GLP-1 medicines, Dementia, Alzheimer's & cognitive decline, Fat loss, obesity & body recomposition, Gallbladder and gallstones, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Insulin resistance, prediabetes & type 2 diabetes, Pancreatitis (after the acute phase), Post-surgical inflammation and surgery recovery.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).