What is Sincalide?

A synthetic 8-amino-acid fragment of cholecystokinin (Kinevac) used in gallbladder and pancreas imaging.

Sincalide in the library · · Human Trials · What are peptides?

4 registered trials · 64 indexed papers · 108 human / 320 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A synthetic 8-amino-acid fragment of cholecystokinin (Kinevac) used in gallbladder and pancreas imaging.

Type: Peptide (CCK fragment).

Definition (National Library of Medicine)

“An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.”

MeSH: Sincalide

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Sincalide is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (4)

Trial	Phase	Status	Year	Enrolled
Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants	Phase 1	completed	2020	9
A Study Evaluating the Effect of Albiglutide on Gallbladder Emptying in Healthy Subjects	Phase 4	completed	2015	20
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)	Phase 3	completed	2008	31
Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis		completed	1997	252

Peer-reviewed studies (64)

Paper	Authors	Journal	Year	Type
In vitro gastric emptying characteristics of konjac glucomannan with different viscosity and its effects on appetite regulation	Shang L et al.	Food & function	2020	Randomized Controlled Trial
Appetite responses to high-fat diets rich in mono-unsaturated versus poly-unsaturated fats	Polley KR et al.	Appetite	2019	Randomized Controlled Trial
The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes	Brønden A et al.	Diabetes, obesity & metabolism	2018	Randomized Controlled Trial
Effect of resistant wheat starch on subjective appetite and food intake in healthy adults	Emilien CH et al.	Nutrition (Burbank, Los Angeles County, Calif.)	2017	Randomized Controlled Trial
Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans	Gibbons C et al.	Peptides	2016	Randomized Controlled Trial
Effects of multiple-target anti-microRNA antisense oligodeoxyribonucleotides on proliferation and migration of gastric cancer cells	Xu L et al.	Asian Pacific journal of cancer prevention : APJCP	2012	Randomized Controlled Trial
Sincalide-stimulated cholescintigraphy: a multicenter investigation to determine optimal infusion methodology and gallbladder ejection fraction normal values	Ziessman HA et al.	Journal of nuclear medicine : official publication, Society of Nuclear Medicine	2010	Clinical Trial
Effect of viscosity on appetite and gastro-intestinal hormones	Zijlstra N et al.	Physiology & behavior	2009	Randomized Controlled Trial
Tonic and phasic pyloric activity in response to CCK-octapeptide	Friedenberg FK et al.	Digestive diseases and sciences	2008	Clinical Trial
A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men	Little TJ et al.	American journal of physiology. Regulatory, integrative and comparative physiology	2008	Randomized Controlled Trial
Effects of long term hydrophilic bile acid therapy on in vitro contraction of gallbladder muscle strips in patients with cholesterol gallstones	Mas MR et al.	World journal of gastroenterology	2007	Randomized Controlled Trial
Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist	Gerskowitch VP et al.	British journal of clinical pharmacology	2007	Clinical Trial, Phase I
Failure of cholecystokinin-octapeptide to prevent TPN-associated gallstone disease	Tsai S et al.	Journal of pediatric surgery	2005	Randomized Controlled Trial
Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis	Teitelbaum DH et al.	Pediatrics	2005	Randomized Controlled Trial
Characterization of basal hepatic bile flow and the effects of intravenous cholecystokinin on the liver, sphincter, and gallbladder in patients with sphincter of Oddi spasm	Krishnamurthy GT et al.	European journal of nuclear medicine and molecular imaging	2004	Controlled Clinical Trial
Cholecystokinin and stomach distension combine to reduce food intake in humans	Kissileff HR et al.	American journal of physiology. Regulatory, integrative and comparative physiology	2003	Controlled Clinical Trial
Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks	Lara N et al.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	2003	Randomized Controlled Trial
Comparison of gallbladder function obtained with regular CCK-8 and pharmacy-compounded CCK-8	Krishnamurthy S et al.	Journal of nuclear medicine : official publication, Society of Nuclear Medicine	2003	Clinical Trial
Cholecystokinin octapeptide increases rectal sensitivity to pain in healthy subjects	Sabaté JM et al.	Neurogastroenterology and motility	2002	Randomized Controlled Trial
Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging	MacIntosh CG et al.	The Journal of clinical endocrinology and metabolism	2001	Randomized Controlled Trial
Gallbladder muscle dysfunction in patients with chronic acalculous disease	Amaral J et al.	Gastroenterology	2001	Clinical Trial
Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans	Gutzwiller JP et al.	American journal of physiology. Regulatory, integrative and comparative physiology	2000	Randomized Controlled Trial
Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes	Ahrén B et al.	The Journal of clinical endocrinology and metabolism	2000	Clinical Trial
In vitro responses of gallbladder muscle from patients with acalculous biliary pain	Ahmed R et al.	Digestion	2000	Controlled Clinical Trial
Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia	Rayner CK et al.	American journal of physiology. Gastrointestinal and liver physiology	2000	Randomized Controlled Trial
Effect of atropine and sincalide on the intestinal uptake of F-18 fluorodeoxyglucose	Jadvar H et al.	Clinical nuclear medicine	1999	Randomized Controlled Trial
Physiological role of cholecystokinin in gastroprotection in humans	Konturek JW et al.	The American journal of gastroenterology	1998	Randomized Controlled Trial
Untangling the effects of hunger, anxiety, and nausea on energy intake during intravenous cholecystokinin octapeptide (CCK-8) infusion	Greenough A et al.	Physiology & behavior	1998	Randomized Controlled Trial
Physiological role of nitric oxide in gallbladder emptying in men	Konturek JW et al.	Digestion	1997	Controlled Clinical Trial
Effect of cholecystokinin octapeptide and atropine on human colonic motility, tone, and transit	O'Brien MD et al.	Digestive diseases and sciences	1997	Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Sincalide?

A synthetic 8-amino-acid fragment of cholecystokinin (Kinevac) used in gallbladder and pancreas imaging.

How many registered human trials study Sincalide?

The PeptideWhiz trial index lists 4 registered trials for Sincalide, the most recent from 2020.

How much published research exists on Sincalide?

The PeptideWhiz paper index links 64 PubMed papers to Sincalide; by study type, 108 human and 320 animal studies.

Which conditions is Sincalide researched for?

Anti-aging & longevity, Anxiety and panic, Chronic and systemic inflammation, Delayed gastric emptying on GLP-1 medicines, Dementia, Alzheimer's & cognitive decline, Gallbladder and gallstones, Insulin resistance, prediabetes & type 2 diabetes.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).