What is Thymulin?

A zinc-dependent nonapeptide hormone made by the thymus, studied for immune and hair-follicle signaling.

Thymulin in the library · Bioregulator Peptides · Human Trials · What are peptides?

0 registered trials · 8 indexed papers · 5 human / 15 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Thymulin is described as a nine-amino-acid peptide secreted by thymic epithelial cells. It needs zinc to be biologically active, which is why blood thymulin levels are used as a marker of zinc status (Palmer et al., 2020).

Research catalogs sell it for immune and hair research.

Mechanism (as described)

It is described as influencing T-cell differentiation and as interacting with the neuroendocrine system (Hadden, 1998).

Status

Not approved.

Peer-reviewed studies (8)

Paper	Authors	Journal	Year	Type
Prenatal and childhood exposures are associated with thymulin concentrations in young adolescent children in rural Nepal	Palmer AC et al.	Journal of developmental origins of health and disease	2020	Randomized Controlled Trial
Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study	Costarelli L et al.	Age (Dordrecht, Netherlands)	2014	Randomized Controlled Trial
Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha1 and thymulin concentrations: observations in rats and humans	Molinero P et al.	Journal of neuroimmunology	2000	Clinical Trial
Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS	Mocchegiani E et al.	International journal of immunopharmacology	1995	Randomized Controlled Trial
A trial of zinc supplementation in young rural Gambian children	Bates CJ et al.	The British journal of nutrition	1993	Controlled Clinical Trial
Zinc supplementation restores plasma concentrations of zinc and thymulin in patients with Crohn's disease	Brignola C et al.	Alimentary pharmacology & therapeutics	1993	Randomized Controlled Trial
Modulation of the neuroendocrine system and immune functions by zinc supplementation in children with Down's syndrome	Licastro F et al.	Journal of trace elements and electrolytes in health and disease	1993	Clinical Trial
Nonathymulin treatment of multiple sclerosis: double-blind pilot study	Roullet E et al.	Acta neurologica Scandinavica	1989	Randomized Controlled Trial

More cited research

Establishment of a sensitive radioimmunoassay for serum thymic factor with a special reference to extraction procedures (1992, human observational)
Circulating thymulin and thymosin-alpha 1 activity in pediatric acquired immune deficiency syndrome: in vivo and in vitro studies (1986, human observational)
Bone marrow transplantation in DiGeorge syndrome (1987, human case report)
Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent (1999, animal)
Immunolocalization of thymosin alpha 1, thymopoietin and thymulin in mouse thymic epithelial cells at different stages of culture: a light and electron microsco (1988, animal)
Immunoreactivity of aqueous extracts of rat and mouse tissue with anti-thymosin alpha 1, anti-bovine thymopoietin and anti-thymulin antibodies. Studies using im (1988, animal)
An enzyme immunoassay for synthetic thymulin (1987, animal)

Conditions researched

Related compounds

FAQ

What is Thymulin?

A zinc-dependent nonapeptide hormone made by the thymus, studied for immune and hair-follicle signaling.

How many registered human trials study Thymulin?

The PeptideWhiz trial index lists 0 registered trials for Thymulin.

How much published research exists on Thymulin?

The PeptideWhiz paper index links 8 PubMed papers to Thymulin; by study type, 5 human and 15 animal studies.

Which conditions is Thymulin researched for?

Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Multiple sclerosis.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).