What is Urocortin?
A family of peptides related to CRH that act on the heart and stress-response system; studied in heart failure trials.
Urocortin in the library · · Human Trials · What are peptides?
3 registered trials · 10 indexed papers · 18 human / 22 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A family of peptides related to CRH that act on the heart and stress-response system; studied in heart failure trials.
Type: Peptide.
Definition (National Library of Medicine)
“Neuropeptides of about 40 amino acids which are structurally similar to corticotropin-releasing factor. Unlike crf acting primarily through type 1 crf receptors, urocortins signal preferentially through type 2 crf receptors. Urocortins have wide tissue distribution from fish to mammals, and diverse functions. In mammals, urocortins can suppress food intake, delays gastric emptying, and decreases heat-induced edema.”
- MeSH: Urocortins
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Urocortin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (3)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Effect of Urocortins in Patients With Heart Failure | completed | 2012 | 22 | |
| Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers - Protocol 4 | completed | 2011 | 12 | |
| Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 2) | completed | 2010 | 12 |
Peer-reviewed studies (10)
More cited research
- Mapping the CRF-urocortins system in human osteoarthritic and rheumatoid synovial fibroblasts: effect of vasoactive intestinal peptide (2011, human observational)
- Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2-CRHR2 Signaling Pathway (2025, animal)
- SUN-257 Evidence that Urocortin 2 Contributes to the Suppressive Effect of Metabolic Stress on LH Secretion in Female Mice (2020, animal)
- Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons (2010, animal)
- Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels (2002, animal)
Conditions researched
- Atherosclerosis, cardiovascular disease & high blood pressure
- Heart repair: after heart attack, heart failure & enlarged heart
- Osteoarthritis, cartilage loss & avoiding joint replacement
- Rheumatoid arthritis
Related compounds
- ACTH (Corticotropin)
- ANP (Atrial Natriuretic Peptide)
- CRH (Corticotropin-Releasing Hormone)
- Calcitonin
- Endothelin-1
- GHK (Copper-Free)
- Ghrelin
- Parathyroid Hormone (PTH 1-84)
- Somatostatin
- Substance P
FAQ
What is Urocortin?
A family of peptides related to CRH that act on the heart and stress-response system; studied in heart failure trials.
How many registered human trials study Urocortin?
The PeptideWhiz trial index lists 3 registered trials for Urocortin, the most recent from 2012.
How much published research exists on Urocortin?
The PeptideWhiz paper index links 10 PubMed papers to Urocortin; by study type, 18 human and 22 animal studies.
Which conditions is Urocortin researched for?
Atherosclerosis, cardiovascular disease & high blood pressure, Heart repair: after heart attack, heart failure & enlarged heart, Osteoarthritis, cartilage loss & avoiding joint replacement, Rheumatoid arthritis.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).