What is Peptide YY?

A 36-amino-acid gut hormone released after eating that is studied for its role in appetite.

Peptide YY in the library · · Human Trials · What are peptides?

11 registered trials · 411 indexed papers · 488 human / 84 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A 36-amino-acid gut hormone released after eating that is studied for its role in appetite.

Type: Gut peptide hormone.

Definition (National Library of Medicine)

“A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.”

  • MeSH: Peptide YY

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Peptide YY is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (11)

TrialPhaseStatusYearEnrolled
Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adultscompleted202316
APPETITE: linguAl PYY3-36 on aPpEtite and acuTe Energy InTakEunknown202240
L-Cell Activity in Small Intestine as Biliopancreatic Loop in Obese Patients With DM2 Submitted to RYGBPunknown202020
Influence of Dairy Protein Breakfast on Glycemia, Weight Loss and Clock Genes in T2Dunknown201860
A Dose Escalating Study to Assess the Safety and Tolerability of GT-001Phase 1completed201712
Degradation of the Anorexic Hormone Peptide YYEARLY_Phase 1completed20148
Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism.completed201124
A Study of Nasal PYY3-36 and Placebo for Weight Loss in Obese SubjectsPhase 2completed2007551
Oral Administration of Peptides; Absorption From Gastrointestinal TractPhase 1completed200612
The Role of Peptide YY (PYY)in Inhibiting Food Intake.completed200524
The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.completed200424

Peer-reviewed studies (411)

PaperAuthorsJournalYearType
Satiety responsiveness following dietary exposure to ultra-processed foods differing in texture-derived eating rate: a secondary analysis of a randomized controlled crossover diet interventionvan Bruinessen M et al.European journal of nutrition2026Randomized Controlled Trial
Safety and efficacy of Lacticaseibacillus rhamnosus LRa05, Limosilactobacillus reuteri LR08, and Lactobacillus crispatus LCr86 on hormone metabolism, body composition, and emotional regulation in overweight women: a randomized, double - blind, placebo - controlled trialYin L et al.Journal of applied microbiology2026Randomized Controlled Trial
Postprandial metabolic responses to a glycomacropeptide-based protein substitute in different meal contexts - Implications for phenylketonuria (PKU)Rodrigues C et al.Clinical nutrition (Edinburgh, Scotland)2026Randomized Controlled Trial
Food intake sequence affects postprandial metabolic, hormonal, and appetite responses in healthy male football players: A randomised crossover trialGiro R et al.Clinical nutrition ESPEN2026Randomized Controlled Trial
Small intestinal compared with colonic short-chain fatty acid delivery drives distinct systemic concentrations and endocrine responses in humans: a randomized, crossover trialRosseel R et al.The American journal of clinical nutrition2026Randomized Controlled Trial
Acute appetite and gut-hormone responses to two combined training sessions: a randomized crossover study in men with obesityLi N et al.European journal of clinical nutrition2026Randomized Controlled Trial
Effect of continuous energy restriction combined with probiotic supplementation on parameters related to homeostatic and hedonic systems of food intake in adult men living with obesity: Data from a randomized, parallel, double-blind, placebo-controlled clinical trialLucin GA et al.Clinical nutrition ESPEN2026Randomized Controlled Trial
Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeostasis after bariatric surgery in non-diabetic womenAndreoli MF et al.Journal of neuroendocrinology2026Randomized Controlled Trial
A randomised, double-blind, placebo-controlled trial to assess the postprandial dose-dependent effects of wild blueberries on metabolic and cognitive outcomes following a high-carbohydrate breakfastEllis LR et al.European journal of nutrition2026Randomized Controlled Trial
The Role of High-Protein Instant Ramen Noodles in Inducing and Maintaining Satiety: Acute, Randomized, Crossover StudyOzioma PU et al.Nutrition & diabetes2026Randomized Controlled Trial
Appetite regulation following energy restriction with almond-enriched vs. nut-free diets - a randomised controlled trialCarter S et al.Obesity research & clinical practice2026Randomized Controlled Trial
Changes of gut microbiota, hormone and glycolipid metabolism by dietary fiber (oat bran) supplementation in patients with laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass: A randomized controlled studyHu H et al.Nutrition (Burbank, Los Angeles County, Calif.)2026Randomized Controlled Trial
The effects of time-restricted eating on energy balance regulation in adults with overweight/obesity and type 2 diabetesKramer CK et al.International journal of obesity (2005)2026Randomized Controlled Trial
Acute L-Leucine Supplementation and Sprint Exercise Elicit Distinct Appetite and Inflammatory Responses in Persons with Overweight: A Randomized, Counterbalanced, and Crossover Design StudyFrança E et al.Nutrients2026Randomized Controlled Trial
Impact of Vertical Sleeve Gastrectomy in Youth-Onset Type 2 Diabetes: Changes in Glycemia, Insulin Sensitivity, and SecretionDobbs TJ et al.Obesity (Silver Spring, Md.)2026Clinical Trial, Phase II
Appetite responses to different doses of cottonseed oil in adults at risk of cardiovascular diseaseHawkins CD et al.Physiology & behavior2026Randomized Controlled Trial
Roux-en-Y Gastric Bypass Improves Insulin Response and Secretion of GLP-1 and PYY in Response to Postprandial Acute ExerciseGil S et al.Obesity surgery2025Randomized Controlled Trial
Effects of 4:3 Intermittent Fasting on Eating Behaviors and Appetite Hormones: A Secondary Analysis of a 12-Month Behavioral Weight Loss InterventionBreit MJ et al.Nutrients2025Randomized Controlled Trial
The effects of collagen peptide supplementation on appetite and post-exercise energy intake in females: a randomised controlled trialReynolds KM et al.The British journal of nutrition2025Randomized Controlled Trial
Long-acting PYY(3) (-36) analogue with semaglutide for obesity: from preclinical assessment through randomized clinical studiesWulff BS et al.Obesity (Silver Spring, Md.)2025Randomized Controlled Trial
Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low-energy dietFanni G et al.Diabetes, obesity & metabolism2025Randomized Controlled Trial
The acute effects of moderate-intensity continuous or high-intensity interval exercise on appetite and appetite-related hormones in South Asian and white European adults with non-diabetic hyperglycaemiaShen T et al.European journal of clinical nutrition2025Randomized Controlled Trial
Effects of exercise conducted prior to phenylketonuria-type meal on appetite, satiety hormones and energy expenditure: a randomised cross-over trialAlghamdi NA et al.European journal of clinical nutrition2025Randomized Controlled Trial
Objective and subjective appetite measures: high versus low eating frequency in a randomized crossover clinical trialZhang X et al.Obesity (Silver Spring, Md.)2025Randomized Controlled Trial
Are post-exercise plasma glucose elevations involved in exercise-induced appetite suppression?Bornath D et al.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2025Randomized Controlled Trial
Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie dietLowe AC et al.Clinical obesity2025Observational Study
Plasma concentration of gastrointestinal hormones and subjective appetite ratings after diet or bariatric surgery: 1-year results from the DISGAP studyAukan MI et al.International journal of obesity (2005)2025Clinical Trial
Gastrointestinal hormones and subjective ratings of appetite after low-carbohydrate vs low-fat low-energy diets in females with lipedema - A randomized controlled trialLundanes J et al.Clinical nutrition ESPEN2025Randomized Controlled Trial
Substituting Carbohydrate at Lunch for Added Protein Increases Fat Oxidation During Subsequent Exercise in Healthy MalesSlater T et al.The Journal of clinical endocrinology and metabolism2025Randomized Controlled Trial
Effect of Barley on Postprandial Blood Glucose Response and Appetite in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled TrialKim IS et al.Nutrients2024Randomized Controlled Trial

More cited research

Conditions researched

Related compounds

FAQ

What is Peptide YY?

A 36-amino-acid gut hormone released after eating that is studied for its role in appetite.

How many registered human trials study Peptide YY?

The PeptideWhiz trial index lists 11 registered trials for Peptide YY, the most recent from 2023.

How much published research exists on Peptide YY?

The PeptideWhiz paper index links 411 PubMed papers to Peptide YY; by study type, 488 human and 84 animal studies.

Which conditions is Peptide YY researched for?

Acid reflux and GERD, Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Cognition, focus & brain performance, Delayed gastric emptying on GLP-1 medicines, Fat loss, obesity & body recomposition, Fatty liver & elevated liver enzymes, Gallbladder and gallstones, Gut: IBD (Crohn's, colitis), leaky gut, IBS & ulcers, Immune system (general), Insulin resistance, prediabetes & type 2 diabetes, Lipedema, Pancreatitis (after the acute phase), PCOS, Post-surgical inflammation and surgery recovery, Sleep problems (incl. insomnia on peptides).

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).