What is Bestim?

A gamma-linked Glu-Trp dipeptide immunomodulator registered in Russia; tested in the US as SCV-07 for oral mucositis.

Bestim in the library · · Human Trials · What are peptides?

4 registered trials · 3 indexed papers

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

Bestim is described as gamma-D-glutamyl-L-tryptophan. It is related to but not the same as Thymogen (alpha-linked Glu-Trp), which has its own page.

Mechanism (as described)

It is described as stimulating T-cell and cytokine responses.

Evidence (as described)

Human data include Russian clinical studies (for example in peptic ulcer, Tkacheva et al., 2004) and a US program for chemoradiation mucositis (Alterovitz et al., 2011).

Status

Registered in Russia; not approved in the US.

Registered human trials (4)

Trial	Phase	Status	Year	Enrolled
Study to Evaluate the Efficacy and Safety of Three Different Doses of SCV 07 in Attenuating Oral Mucositis in Subjects With Head and Neck Cancer	Phase 2	unknown	2010	160
Extension Study SCI-SCV-HCV-P2-001: Long-Term FU in Subj Who Opt for Retreatment With Peg-INF and RBV After Completing Treatment in HCV		completed	2010	12
Proof-of-concept Study to Evaluate the Safety and Immunomodulatory Effects of SCV 07 as Monotherapy or in Combination With Ribavirin in Noncirrhotic Subjects With Chronic Hepatitis C Who Have Relapsed	Phase 2	completed	2009	40
Dose Ranging Study to Assess the Safety and Efficacy of SCV-07 for the Delay to Onset of Severe Oral Mucositis in Patients Receiving Chemoradiation Therapy for Head and Neck Cancer	Phase 2	completed	2008	59

Peer-reviewed studies (3)

Paper	Authors	Journal	Year	Type
Personalized medicine for mucositis: Bayesian networks identify unique gene clusters which predict the response to gamma-D-glutamyl-L-tryptophan (SCV-07) for the attenuation of chemoradiation-induced oral mucositis	Alterovitz G et al.	Oral oncology	2011	Clinical Trial
[Impact of Bestim on the immunological status and clinical course of ulcer]	Tkacheva AG et al.	Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology	2004	Controlled Clinical Trial
gamma-L-glutamyl-5-hydroxy-L-tryptophan, but not gamma-L-glutamyl-L-tryptophan, causes sodium retention in normal man	Li Kam Wa TC et al.	British journal of clinical pharmacology	1996	Randomized Controlled Trial

Conditions researched

Related compounds

FAQ

What is Bestim?

A gamma-linked Glu-Trp dipeptide immunomodulator registered in Russia; tested in the US as SCV-07 for oral mucositis.

How many registered human trials study Bestim?

The PeptideWhiz trial index lists 4 registered trials for Bestim, the most recent from 2010.

How much published research exists on Bestim?

The PeptideWhiz paper index links 3 PubMed papers to Bestim.

Which conditions is Bestim researched for?

Gum disease (periodontal) & oral health, Immune system (general).

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).