What is Elafin?
A 57-amino-acid natural protease inhibitor; tiprelestat is a recombinant form studied in surgery-related inflammation.
Elafin in the library · · Human Trials · What are peptides?
2 registered trials · 17 indexed papers · 30 human / 1 animal studies
From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.
What it is
A 57-amino-acid natural protease inhibitor; tiprelestat is a recombinant form studied in surgery-related inflammation.
Type: Peptide.
Definition (National Library of Medicine)
“A secretory proteinase inhibitory protein that was initially purified from human skin. It is found in a variety mucosal secretions and is present at high levels in sputum. Elafin may play a role in the innate immunity (immunity, innate) response of the lung.”
- MeSH: Elafin
Human research
The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Elafin is one of its interventions, or is named in the study title or subject headings.
Listing a study does not mean it showed a benefit, and it is not medical advice.
Registered human trials (2)
| Trial | Phase | Status | Year | Enrolled |
|---|---|---|---|---|
| Tiprelestat Versus Placebo When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH) | Phase 2 | not yet recruiting | 2026 | 90 |
| Subcutaneous Elafin in Healthy Subjects | Phase 1 | completed | 2019 | 30 |
Peer-reviewed studies (17)
Conditions researched
- Atherosclerosis, cardiovascular disease & high blood pressure
- Chronic and systemic inflammation
- Diabetic retinopathy and glaucoma
- Eczema
- Immune system (general)
- Lung health, asthma & COPD
- Post-surgical inflammation and surgery recovery
- Pregnancy and breastfeeding: safety notes
Related compounds
- ACTH (Corticotropin)
- Endothelin-1
- Adrenomedullin
- BNP (Nesiritide)
- Bradykinin
- Cyanocobalamin (Vitamin B12)
- Exenatide
- Ghrelin
- Insulin (regular human)
- Liraglutide
FAQ
What is Elafin?
A 57-amino-acid natural protease inhibitor; tiprelestat is a recombinant form studied in surgery-related inflammation.
How many registered human trials study Elafin?
The PeptideWhiz trial index lists 2 registered trials for Elafin, the most recent from 2026.
How much published research exists on Elafin?
The PeptideWhiz paper index links 17 PubMed papers to Elafin; by study type, 30 human and 1 animal studies.
Which conditions is Elafin researched for?
Atherosclerosis, cardiovascular disease & high blood pressure, Chronic and systemic inflammation, Diabetic retinopathy and glaucoma, Eczema, Immune system (general), Lung health, asthma & COPD, Post-surgical inflammation and surgery recovery, Pregnancy and breastfeeding: safety notes.
Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).