What is Felypressin?

A synthetic vasopressin analog added to some dental local anesthetics to narrow blood vessels.

Felypressin in the library · · Human Trials · What are peptides?

1 registered trials · 31 indexed papers · 34 human / 12 animal studies

From the PeptideWhiz library entry. "As described" sections summarize claims made in the sources; they are not PeptideWhiz endorsements.

What it is

A synthetic vasopressin analog added to some dental local anesthetics to narrow blood vessels.

Type: Synthetic vasopressin analog.

Definition (National Library of Medicine)

“A synthetic analog of lypressin with a phenylalanine substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.”

MeSH: Felypressin

Human research

The registered human trials and peer-reviewed human studies linked below are listed from ClinicalTrials.gov and PubMed. A study is linked only when Felypressin is one of its interventions, or is named in the study title or subject headings.

Listing a study does not mean it showed a benefit, and it is not medical advice.

Registered human trials (1)

Trial	Phase	Status	Year	Enrolled
Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth	Phase 4	completed	2017	95

Peer-reviewed studies (31)

Paper	Authors	Journal	Year	Type
Comparison of two vasoconstrictors on glycemic levels in diabetic patients	Meneses-Santos D et al.	Clinical oral investigations	2020	Randomized Controlled Trial
Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A Randomized Controlled Trial	Yamashita K et al.	Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons	2020	Randomized Controlled Trial
Cardiovascular Comparison of 2 Types of Local Anesthesia With Vasoconstrictor in Older Adults: A Crossover Study	Kyosaka Y et al.	Anesthesia progress	2019	Randomized Controlled Trial
The effect of different vasoconstrictors and local anesthetic solutions on substance P expression in human dental pulp	Caviedes-Bucheli J et al.	Journal of endodontics	2009	Randomized Controlled Trial
Effect of local anesthetics with and without vasoconstrictor agent in patients with ventricular arrhythmias	Cáceres MT et al.	Arquivos brasileiros de cardiologia	2008	Randomized Controlled Trial
A double-blind, randomized, placebo-controlled trial of prilocaine and felypressin (Citanest and Octapressin) for the relief of pain associated with cervical biopsy and treatment with the Semm coagulator	Duncan ID et al.	Journal of lower genital tract disease	2005	Randomized Controlled Trial
Effects of dental local anaesthetics in cardiac transplant recipients	Meechan JG et al.	British dental journal	2002	Controlled Clinical Trial
Clinical and radiographic evaluation of pulpotomies performed under intrapulpal injection of anaesthetic solution	Teixeira LS et al.	International endodontic journal	2001	Randomized Controlled Trial
The influence of two different dental local anaesthetic solutions on the haemodynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study	Meechan JG et al.	British dental journal	2001	Randomized Controlled Trial
Alterations in monitored vital constants induced by various local anesthetics in combination with different vasoconstrictors in the surgical removal of lower third molars	Carrera I et al.	Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie	2000	Randomized Controlled Trial
A comparison of the side effects of prilocaine with felypressin and lignocaine with adrenaline in large loop excision of the transformation zone of the cervix: results of a randomised trial	Howells RE et al.	BJOG : an international journal of obstetrics and gynaecology	2000	Randomized Controlled Trial
Peribulbar anaesthesia: a double-blind comparison of three local anaesthetic solutions	Bedi A et al.	Anaesthesia	1999	Randomized Controlled Trial
A comparative study of anesthetic techniques for mandibular dental extraction	Dumbrigue HB et al.	American journal of dentistry	1997	Randomized Controlled Trial
Lidocaine and prilocaine with vasoconstrictors as cause for cardiovascular reactions. A pulse oximetric study. Preliminary report	Ryhänen JM et al.	Oral surgery, oral diagnosis : OSD	1996	Clinical Trial
Clinically safe dosage of felypressin for patients with essential hypertension	Sunada K et al.	Anesthesia progress	1996	Clinical Trial
Metabolic responses to oral surgery under local anesthesia and sedation with intravenous midazolam: the effects of two different local anesthetics	Meechan JG et al.	Anesthesia progress	1992	Randomized Controlled Trial
The effects of two different local anaesthetic solutions administered for oral surgery on plasma potassium levels in patients taking kaliuretic diuretics	Meechan JG et al.	European journal of clinical pharmacology	1992	Randomized Controlled Trial
The effects of dental local anaesthetics on blood glucose concentration in healthy volunteers and in patients having third molar surgery	Meechan JG	British dental journal	1991	Controlled Clinical Trial
[Clinical comparison of Xylonest-Octapressin and Scandicain]	Schwenzer N et al.	ZWR	1991	Controlled Clinical Trial
[General complications in dental local anesthesia]	Hidding J et al.	Deutsche zahnarztliche Zeitschrift	1991	Randomized Controlled Trial
[Clinical comparative study of local anesthetics. Random double blind study with four commercial preparations]	Khoury F et al.	Deutsche zahnarztliche Zeitschrift	1991	Randomized Controlled Trial
The effects of two different dental local anesthetic solutions on plasma potassium levels during third molar surgery	Meechan JG et al.	Oral surgery, oral medicine, and oral pathology	1988	Controlled Clinical Trial
A randomized trial of Citanest with Octapressin for relief of pain associated with laser vaporization of the cervix	Lee ET et al.	British journal of obstetrics and gynaecology	1986	Randomized Controlled Trial
Plasma catecholamine concentrations. The effects of infiltration with local analgesics and vasoconstrictors during nasal operations	Taylor S et al.	Anaesthesia	1984	Randomized Controlled Trial
A comparison of four commonly used local analgesics	Petersen JK et al.	International journal of oral surgery	1977	Controlled Clinical Trial
[Clinical studies with the double blind technic on the use of octapressin combined with cytanest in dentistry]	Baratieri A et al.	Rivista italiana di stomatologia	1970	Controlled Clinical Trial
Octopressin as a vasoconstrictor in anaesthetics used for oral surgery	Persson G et al.	Svensk tandlakare tidskrift. Swedish dental journal	1969	Clinical Trial
Prilocaine-felypressin: a new combination for dental analgesia	Goldman V et al.	The Dental practitioner and dental record	1969	Controlled Clinical Trial
Systemic vasoconstrictor and renal vasodilator effects of PLV-2 (octapressin) in man	Cohn JN et al.	Circulation	1968	Clinical Trial
[Clinical study of a new local blocking agent with a polypeptide vasoconstrictor (Citanest-Octapresin) in patients with cardiovascular and other changes]	Nava Rivera A et al.	ADM; revista de la Asociacion Dental Mexicana	1967	Clinical Trial

Conditions researched

Related compounds

FAQ

What is Felypressin?

A synthetic vasopressin analog added to some dental local anesthetics to narrow blood vessels.

How many registered human trials study Felypressin?

The PeptideWhiz trial index lists 1 registered trial for Felypressin, the most recent from 2017.

How much published research exists on Felypressin?

The PeptideWhiz paper index links 31 PubMed papers to Felypressin; by study type, 34 human and 12 animal studies.

Which conditions is Felypressin researched for?

Atherosclerosis, cardiovascular disease & high blood pressure, Post-surgical inflammation and surgery recovery.

Research and education only. Not medical advice. No dosing guidance. Data: ClinicalTrials.gov registry and PubMed via the PeptideWhiz index (204,289 studies).